Serum levels of soluble CD26 and CD30 in patients on hemodialysis

Kazushi Nakao, Yoshio Nagake, Akira Okamoto, Haruo Ichikawa, Masahiro Yamamura, Hirofumi Makino

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Background/Aims: Various abnormalities of the immune system have been demonstrated in patients on hemodialysis (HD). We hypothesize that the imbalance between type 1 helper T (Th1) cells and type 2 helper T (Th2) cells in patients on HD contributes to these abnormalities. Furthermore, we investigate the relationship between the Th1/Th2 imbalance and HD duration. Methods: We measured the serum levels of soluble CD26 (sCD26) and soluble CD30 (sCD30) in 47 patients on HD and in 13 patients with chronic renal failure not on HD and analyzed the effect of HD duration on the serum levels of sCD26 and sCD30. Results: The serum level of sCD26 in the HD group was significantly lower than that in the control group. On the other hand, the serum levels of sCD30 in the HD group and in the CRF group were significantly higher than in the control group. In the short-term HD group (<1 year), the serum levels of sCD26 were lower and the sCD30 levels higher than those in middle-term HD group (1-10 years). Conclusions: In the HD group, the Th1/Th2 balance may shift towards Th2 dominance. It is possible that this imbalance contributes to the abnormality of the immune system in HD patients.

Original languageEnglish
Pages (from-to)215-221
Number of pages7
JournalNephron
Volume91
Issue number2
DOIs
Publication statusPublished - Jun 22 2002

Fingerprint

Renal Dialysis
Serum
Th2 Cells
Th1 Cells
Immune System
Th1-Th2 Balance
Control Groups
Chronic Kidney Failure

Keywords

  • Hemodialysis
  • Hemodialysis duration
  • Soluble CD26
  • Soluble CD30
  • Th1
  • Th2

ASJC Scopus subject areas

  • Nephrology

Cite this

Nakao, K., Nagake, Y., Okamoto, A., Ichikawa, H., Yamamura, M., & Makino, H. (2002). Serum levels of soluble CD26 and CD30 in patients on hemodialysis. Nephron, 91(2), 215-221. https://doi.org/10.1159/000058395

Serum levels of soluble CD26 and CD30 in patients on hemodialysis. / Nakao, Kazushi; Nagake, Yoshio; Okamoto, Akira; Ichikawa, Haruo; Yamamura, Masahiro; Makino, Hirofumi.

In: Nephron, Vol. 91, No. 2, 22.06.2002, p. 215-221.

Research output: Contribution to journalArticle

Nakao, K, Nagake, Y, Okamoto, A, Ichikawa, H, Yamamura, M & Makino, H 2002, 'Serum levels of soluble CD26 and CD30 in patients on hemodialysis', Nephron, vol. 91, no. 2, pp. 215-221. https://doi.org/10.1159/000058395
Nakao K, Nagake Y, Okamoto A, Ichikawa H, Yamamura M, Makino H. Serum levels of soluble CD26 and CD30 in patients on hemodialysis. Nephron. 2002 Jun 22;91(2):215-221. https://doi.org/10.1159/000058395
Nakao, Kazushi ; Nagake, Yoshio ; Okamoto, Akira ; Ichikawa, Haruo ; Yamamura, Masahiro ; Makino, Hirofumi. / Serum levels of soluble CD26 and CD30 in patients on hemodialysis. In: Nephron. 2002 ; Vol. 91, No. 2. pp. 215-221.
@article{6f271b4bbfbf49b994b149c61db6082b,
title = "Serum levels of soluble CD26 and CD30 in patients on hemodialysis",
abstract = "Background/Aims: Various abnormalities of the immune system have been demonstrated in patients on hemodialysis (HD). We hypothesize that the imbalance between type 1 helper T (Th1) cells and type 2 helper T (Th2) cells in patients on HD contributes to these abnormalities. Furthermore, we investigate the relationship between the Th1/Th2 imbalance and HD duration. Methods: We measured the serum levels of soluble CD26 (sCD26) and soluble CD30 (sCD30) in 47 patients on HD and in 13 patients with chronic renal failure not on HD and analyzed the effect of HD duration on the serum levels of sCD26 and sCD30. Results: The serum level of sCD26 in the HD group was significantly lower than that in the control group. On the other hand, the serum levels of sCD30 in the HD group and in the CRF group were significantly higher than in the control group. In the short-term HD group (<1 year), the serum levels of sCD26 were lower and the sCD30 levels higher than those in middle-term HD group (1-10 years). Conclusions: In the HD group, the Th1/Th2 balance may shift towards Th2 dominance. It is possible that this imbalance contributes to the abnormality of the immune system in HD patients.",
keywords = "Hemodialysis, Hemodialysis duration, Soluble CD26, Soluble CD30, Th1, Th2",
author = "Kazushi Nakao and Yoshio Nagake and Akira Okamoto and Haruo Ichikawa and Masahiro Yamamura and Hirofumi Makino",
year = "2002",
month = "6",
day = "22",
doi = "10.1159/000058395",
language = "English",
volume = "91",
pages = "215--221",
journal = "Experimental Nephrology",
issn = "0028-2766",
publisher = "S. Karger AG",
number = "2",

}

TY - JOUR

T1 - Serum levels of soluble CD26 and CD30 in patients on hemodialysis

AU - Nakao, Kazushi

AU - Nagake, Yoshio

AU - Okamoto, Akira

AU - Ichikawa, Haruo

AU - Yamamura, Masahiro

AU - Makino, Hirofumi

PY - 2002/6/22

Y1 - 2002/6/22

N2 - Background/Aims: Various abnormalities of the immune system have been demonstrated in patients on hemodialysis (HD). We hypothesize that the imbalance between type 1 helper T (Th1) cells and type 2 helper T (Th2) cells in patients on HD contributes to these abnormalities. Furthermore, we investigate the relationship between the Th1/Th2 imbalance and HD duration. Methods: We measured the serum levels of soluble CD26 (sCD26) and soluble CD30 (sCD30) in 47 patients on HD and in 13 patients with chronic renal failure not on HD and analyzed the effect of HD duration on the serum levels of sCD26 and sCD30. Results: The serum level of sCD26 in the HD group was significantly lower than that in the control group. On the other hand, the serum levels of sCD30 in the HD group and in the CRF group were significantly higher than in the control group. In the short-term HD group (<1 year), the serum levels of sCD26 were lower and the sCD30 levels higher than those in middle-term HD group (1-10 years). Conclusions: In the HD group, the Th1/Th2 balance may shift towards Th2 dominance. It is possible that this imbalance contributes to the abnormality of the immune system in HD patients.

AB - Background/Aims: Various abnormalities of the immune system have been demonstrated in patients on hemodialysis (HD). We hypothesize that the imbalance between type 1 helper T (Th1) cells and type 2 helper T (Th2) cells in patients on HD contributes to these abnormalities. Furthermore, we investigate the relationship between the Th1/Th2 imbalance and HD duration. Methods: We measured the serum levels of soluble CD26 (sCD26) and soluble CD30 (sCD30) in 47 patients on HD and in 13 patients with chronic renal failure not on HD and analyzed the effect of HD duration on the serum levels of sCD26 and sCD30. Results: The serum level of sCD26 in the HD group was significantly lower than that in the control group. On the other hand, the serum levels of sCD30 in the HD group and in the CRF group were significantly higher than in the control group. In the short-term HD group (<1 year), the serum levels of sCD26 were lower and the sCD30 levels higher than those in middle-term HD group (1-10 years). Conclusions: In the HD group, the Th1/Th2 balance may shift towards Th2 dominance. It is possible that this imbalance contributes to the abnormality of the immune system in HD patients.

KW - Hemodialysis

KW - Hemodialysis duration

KW - Soluble CD26

KW - Soluble CD30

KW - Th1

KW - Th2

UR - http://www.scopus.com/inward/record.url?scp=0036016888&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036016888&partnerID=8YFLogxK

U2 - 10.1159/000058395

DO - 10.1159/000058395

M3 - Article

C2 - 12053056

AN - SCOPUS:0036016888

VL - 91

SP - 215

EP - 221

JO - Experimental Nephrology

JF - Experimental Nephrology

SN - 0028-2766

IS - 2

ER -