Serum levels of IL-6 and IL-1β can predict the efficacy of gemcitabine in patients with advanced pancreatic cancer

S. Mitsunaga, M. Ikeda, S. Shimizu, I. Ohno, J. Furuse, M. Inagaki, S. Higashi, H. Kato, K. Terao, A. Ochiai

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Abstract

Background:With this study, we sought to characterise the impact of pro-inflammatory cytokines on the outcomes of gemcitabine monotherapy (GEM) in patients with pancreatic cancer (PC).Methods:Treatment-naive patients with advanced PC and no obvious infections were eligible for enrolment. All of the patients were scheduled to undergo systemic chemotherapy. Serum pro-inflammatory cytokines were measured using an electro-chemiluminescence assay method before chemotherapy. High cytokine levels were defined as values greater than the median. Clinical data were collected prospectively.Results:Sixty patients who received GEM were included in the analysis. High IL-6 and IL-1β levels were poor prognostic factors for overall survival in a multivariate analysis (P=0.011 and P=0.048, respectively). Patients with both a high IL-6 level and a high IL-1β level exhibited shortened overall and progression-free survival, a reduction in the tumour control rate, and a high dose intensity of GEM compared with patients with low levels of both IL-6 and IL-1β.Conclusion: The serum levels of IL-6 and IL-1β predict the efficacy of GEM in patients with advanced PC.

Original languageEnglish
Pages (from-to)2063-2069
Number of pages7
JournalBritish Journal of Cancer
Volume108
Issue number10
DOIs
Publication statusPublished - May 1 2013

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ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Mitsunaga, S., Ikeda, M., Shimizu, S., Ohno, I., Furuse, J., Inagaki, M., Higashi, S., Kato, H., Terao, K., & Ochiai, A. (2013). Serum levels of IL-6 and IL-1β can predict the efficacy of gemcitabine in patients with advanced pancreatic cancer. British Journal of Cancer, 108(10), 2063-2069. https://doi.org/10.1038/bjc.2013.174