Serum levels of complement C4 fragments correlate with disease activity in multiple sclerosis: Proteomic analysis

Setsu Sawai, Hiroshi Umemura, Masahiro Mori, Mamoru Satoh, Sei Hayakawa, Yoshio Kodera, Takeshi Tomonaga, Satoshi Kuwabara, Fumio Nomura

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

To detect serum biomarkers associated with disease activity in relapsing-remitting multiple sclerosis (MS). We studied serum low-molecular peptide profiling of MS patients and normal controls comprehensively by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Serum level of 1741 Da peptide was increased at the time of clinical relapse in patients than in normal controls and returned toward normal during remission. Tandem mass spectrometry analysis revealed that the peptide was a fragment of complement C4 (NGFKSHALQLNNRQI). This fragment peptide could be a possible marker of disease activity. It may reflect complement activation in the pathogenesis of MS.

Original languageEnglish
Pages (from-to)112-115
Number of pages4
JournalJournal of Neuroimmunology
Volume218
Issue number1-2
DOIs
Publication statusPublished - Jan 25 2010

Keywords

  • Complement
  • Multiple sclerosis
  • Proteomics

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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