Abstract
To detect serum biomarkers associated with disease activity in relapsing-remitting multiple sclerosis (MS). We studied serum low-molecular peptide profiling of MS patients and normal controls comprehensively by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Serum level of 1741 Da peptide was increased at the time of clinical relapse in patients than in normal controls and returned toward normal during remission. Tandem mass spectrometry analysis revealed that the peptide was a fragment of complement C4 (NGFKSHALQLNNRQI). This fragment peptide could be a possible marker of disease activity. It may reflect complement activation in the pathogenesis of MS.
| Original language | English |
|---|---|
| Pages (from-to) | 112-115 |
| Number of pages | 4 |
| Journal | Journal of Neuroimmunology |
| Volume | 218 |
| Issue number | 1-2 |
| DOIs | |
| Publication status | Published - Jan 25 2010 |
| Externally published | Yes |
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Keywords
- Complement
- Multiple sclerosis
- Proteomics
ASJC Scopus subject areas
- Immunology
- Clinical Neurology
- Immunology and Allergy
- Neurology
Cite this
Serum levels of complement C4 fragments correlate with disease activity in multiple sclerosis : Proteomic analysis. / Sawai, Setsu; Umemura, Hiroshi; Mori, Masahiro; Satoh, Mamoru; Hayakawa, Sei; Kodera, Yoshio; Tomonaga, Takeshi; Kuwabara, Satoshi; Nomura, Fumio.
In: Journal of Neuroimmunology, Vol. 218, No. 1-2, 25.01.2010, p. 112-115.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Serum levels of complement C4 fragments correlate with disease activity in multiple sclerosis
T2 - Proteomic analysis
AU - Sawai, Setsu
AU - Umemura, Hiroshi
AU - Mori, Masahiro
AU - Satoh, Mamoru
AU - Hayakawa, Sei
AU - Kodera, Yoshio
AU - Tomonaga, Takeshi
AU - Kuwabara, Satoshi
AU - Nomura, Fumio
PY - 2010/1/25
Y1 - 2010/1/25
N2 - To detect serum biomarkers associated with disease activity in relapsing-remitting multiple sclerosis (MS). We studied serum low-molecular peptide profiling of MS patients and normal controls comprehensively by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Serum level of 1741 Da peptide was increased at the time of clinical relapse in patients than in normal controls and returned toward normal during remission. Tandem mass spectrometry analysis revealed that the peptide was a fragment of complement C4 (NGFKSHALQLNNRQI). This fragment peptide could be a possible marker of disease activity. It may reflect complement activation in the pathogenesis of MS.
AB - To detect serum biomarkers associated with disease activity in relapsing-remitting multiple sclerosis (MS). We studied serum low-molecular peptide profiling of MS patients and normal controls comprehensively by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Serum level of 1741 Da peptide was increased at the time of clinical relapse in patients than in normal controls and returned toward normal during remission. Tandem mass spectrometry analysis revealed that the peptide was a fragment of complement C4 (NGFKSHALQLNNRQI). This fragment peptide could be a possible marker of disease activity. It may reflect complement activation in the pathogenesis of MS.
KW - Complement
KW - Multiple sclerosis
KW - Proteomics
UR - http://www.scopus.com/inward/record.url?scp=73249115505&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=73249115505&partnerID=8YFLogxK
U2 - 10.1016/j.jneuroim.2009.10.019
DO - 10.1016/j.jneuroim.2009.10.019
M3 - Article
VL - 218
SP - 112
EP - 115
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
SN - 0165-5728
IS - 1-2
ER -