Serum levels of complement C4 fragments correlate with disease activity in multiple sclerosis: Proteomic analysis

Setsu Sawai; Hiroshi Umemura; Masahiro Mori; Mamoru Satoh; Sei Hayakawa; Yoshio Kodera; Takeshi Tomonaga; Satoshi Kuwabara; Fumio Nomura

doi:10.1016/j.jneuroim.2009.10.019

Serum levels of complement C4 fragments correlate with disease activity in multiple sclerosis: Proteomic analysis

Setsu Sawai, Hiroshi Umemura, Masahiro Mori, Mamoru Satoh, Sei Hayakawa, Yoshio Kodera, Takeshi Tomonaga, Satoshi Kuwabara, Fumio Nomura

University Hospital

Research output: Contribution to journal › Article

17 Citations (Scopus)

Abstract

To detect serum biomarkers associated with disease activity in relapsing-remitting multiple sclerosis (MS). We studied serum low-molecular peptide profiling of MS patients and normal controls comprehensively by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Serum level of 1741 Da peptide was increased at the time of clinical relapse in patients than in normal controls and returned toward normal during remission. Tandem mass spectrometry analysis revealed that the peptide was a fragment of complement C4 (NGFKSHALQLNNRQI). This fragment peptide could be a possible marker of disease activity. It may reflect complement activation in the pathogenesis of MS.

Original language	English
Pages (from-to)	112-115
Number of pages	4
Journal	Journal of Neuroimmunology
Volume	218
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2009.10.019
Publication status	Published - Jan 25 2010

Keywords

Complement
Multiple sclerosis
Proteomics

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

Access to Document

10.1016/j.jneuroim.2009.10.019

Fingerprint Dive into the research topics of 'Serum levels of complement C4 fragments correlate with disease activity in multiple sclerosis: Proteomic analysis'. Together they form a unique fingerprint.

Cite this

Serum levels of complement C4 fragments correlate with disease activity in multiple sclerosis : Proteomic analysis. / Sawai, Setsu; Umemura, Hiroshi; Mori, Masahiro; Satoh, Mamoru; Hayakawa, Sei; Kodera, Yoshio; Tomonaga, Takeshi; Kuwabara, Satoshi; Nomura, Fumio.

In: Journal of Neuroimmunology, Vol. 218, No. 1-2, 25.01.2010, p. 112-115.

Research output: Contribution to journal › Article

@article{7961aed21f464ea3a08596e6ec70ec64,

title = "Serum levels of complement C4 fragments correlate with disease activity in multiple sclerosis: Proteomic analysis",

abstract = "To detect serum biomarkers associated with disease activity in relapsing-remitting multiple sclerosis (MS). We studied serum low-molecular peptide profiling of MS patients and normal controls comprehensively by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Serum level of 1741 Da peptide was increased at the time of clinical relapse in patients than in normal controls and returned toward normal during remission. Tandem mass spectrometry analysis revealed that the peptide was a fragment of complement C4 (NGFKSHALQLNNRQI). This fragment peptide could be a possible marker of disease activity. It may reflect complement activation in the pathogenesis of MS.",

keywords = "Complement, Multiple sclerosis, Proteomics",

author = "Setsu Sawai and Hiroshi Umemura and Masahiro Mori and Mamoru Satoh and Sei Hayakawa and Yoshio Kodera and Takeshi Tomonaga and Satoshi Kuwabara and Fumio Nomura",

year = "2010",

month = jan,

day = "25",

doi = "10.1016/j.jneuroim.2009.10.019",

language = "English",

volume = "218",

pages = "112--115",

journal = "Journal of Neuroimmunology",

issn = "0165-5728",

publisher = "Elsevier",

number = "1-2",

}

TY - JOUR

T1 - Serum levels of complement C4 fragments correlate with disease activity in multiple sclerosis

T2 - Proteomic analysis

AU - Sawai, Setsu

AU - Umemura, Hiroshi

AU - Mori, Masahiro

AU - Satoh, Mamoru

AU - Hayakawa, Sei

AU - Kodera, Yoshio

AU - Tomonaga, Takeshi

AU - Kuwabara, Satoshi

AU - Nomura, Fumio

PY - 2010/1/25

Y1 - 2010/1/25

N2 - To detect serum biomarkers associated with disease activity in relapsing-remitting multiple sclerosis (MS). We studied serum low-molecular peptide profiling of MS patients and normal controls comprehensively by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Serum level of 1741 Da peptide was increased at the time of clinical relapse in patients than in normal controls and returned toward normal during remission. Tandem mass spectrometry analysis revealed that the peptide was a fragment of complement C4 (NGFKSHALQLNNRQI). This fragment peptide could be a possible marker of disease activity. It may reflect complement activation in the pathogenesis of MS.

AB - To detect serum biomarkers associated with disease activity in relapsing-remitting multiple sclerosis (MS). We studied serum low-molecular peptide profiling of MS patients and normal controls comprehensively by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Serum level of 1741 Da peptide was increased at the time of clinical relapse in patients than in normal controls and returned toward normal during remission. Tandem mass spectrometry analysis revealed that the peptide was a fragment of complement C4 (NGFKSHALQLNNRQI). This fragment peptide could be a possible marker of disease activity. It may reflect complement activation in the pathogenesis of MS.

KW - Complement

KW - Multiple sclerosis

KW - Proteomics

UR - http://www.scopus.com/inward/record.url?scp=73249115505&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=73249115505&partnerID=8YFLogxK

U2 - 10.1016/j.jneuroim.2009.10.019

DO - 10.1016/j.jneuroim.2009.10.019

M3 - Article

C2 - 19923011

AN - SCOPUS:73249115505

VL - 218

SP - 112

EP - 115

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

SN - 0165-5728

IS - 1-2

ER -