Serum levels of complement C4 fragments correlate with disease activity in multiple sclerosis: Proteomic analysis

Setsu Sawai; Hiroshi Umemura; Masahiro Mori; Mamoru Satoh; Sei Hayakawa; Yoshio Kodera; Takeshi Tomonaga; Satoshi Kuwabara; Fumio Nomura

doi:10.1016/j.jneuroim.2009.10.019

Serum levels of complement C4 fragments correlate with disease activity in multiple sclerosis: Proteomic analysis

Setsu Sawai, Hiroshi Umemura, Masahiro Mori, Mamoru Satoh, Sei Hayakawa, Yoshio Kodera, Takeshi Tomonaga, Satoshi Kuwabara, Fumio Nomura

University Hospital

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

To detect serum biomarkers associated with disease activity in relapsing-remitting multiple sclerosis (MS). We studied serum low-molecular peptide profiling of MS patients and normal controls comprehensively by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Serum level of 1741 Da peptide was increased at the time of clinical relapse in patients than in normal controls and returned toward normal during remission. Tandem mass spectrometry analysis revealed that the peptide was a fragment of complement C4 (NGFKSHALQLNNRQI). This fragment peptide could be a possible marker of disease activity. It may reflect complement activation in the pathogenesis of MS.

Original language	English
Pages (from-to)	112-115
Number of pages	4
Journal	Journal of Neuroimmunology
Volume	218
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2009.10.019
Publication status	Published - Jan 25 2010

Keywords

Complement
Multiple sclerosis
Proteomics

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

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10.1016/j.jneuroim.2009.10.019

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Serum levels of complement C4 fragments correlate with disease activity in multiple sclerosis : Proteomic analysis. / Sawai, Setsu; Umemura, Hiroshi; Mori, Masahiro; Satoh, Mamoru; Hayakawa, Sei; Kodera, Yoshio; Tomonaga, Takeshi; Kuwabara, Satoshi; Nomura, Fumio.

In: Journal of Neuroimmunology, Vol. 218, No. 1-2, 25.01.2010, p. 112-115.

Research output: Contribution to journal › Article › peer-review

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abstract = "To detect serum biomarkers associated with disease activity in relapsing-remitting multiple sclerosis (MS). We studied serum low-molecular peptide profiling of MS patients and normal controls comprehensively by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Serum level of 1741 Da peptide was increased at the time of clinical relapse in patients than in normal controls and returned toward normal during remission. Tandem mass spectrometry analysis revealed that the peptide was a fragment of complement C4 (NGFKSHALQLNNRQI). This fragment peptide could be a possible marker of disease activity. It may reflect complement activation in the pathogenesis of MS.",

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AU - Sawai, Setsu

AU - Umemura, Hiroshi

AU - Mori, Masahiro

AU - Satoh, Mamoru

AU - Hayakawa, Sei

AU - Kodera, Yoshio

AU - Tomonaga, Takeshi

AU - Kuwabara, Satoshi

AU - Nomura, Fumio

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AB - To detect serum biomarkers associated with disease activity in relapsing-remitting multiple sclerosis (MS). We studied serum low-molecular peptide profiling of MS patients and normal controls comprehensively by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Serum level of 1741 Da peptide was increased at the time of clinical relapse in patients than in normal controls and returned toward normal during remission. Tandem mass spectrometry analysis revealed that the peptide was a fragment of complement C4 (NGFKSHALQLNNRQI). This fragment peptide could be a possible marker of disease activity. It may reflect complement activation in the pathogenesis of MS.

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Serum levels of complement C4 fragments correlate with disease activity in multiple sclerosis: Proteomic analysis

Abstract

Keywords

ASJC Scopus subject areas

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