Abstract
To detect serum biomarkers associated with disease activity in relapsing-remitting multiple sclerosis (MS). We studied serum low-molecular peptide profiling of MS patients and normal controls comprehensively by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Serum level of 1741 Da peptide was increased at the time of clinical relapse in patients than in normal controls and returned toward normal during remission. Tandem mass spectrometry analysis revealed that the peptide was a fragment of complement C4 (NGFKSHALQLNNRQI). This fragment peptide could be a possible marker of disease activity. It may reflect complement activation in the pathogenesis of MS.
Original language | English |
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Pages (from-to) | 112-115 |
Number of pages | 4 |
Journal | Journal of Neuroimmunology |
Volume | 218 |
Issue number | 1-2 |
DOIs | |
Publication status | Published - Jan 25 2010 |
Keywords
- Complement
- Multiple sclerosis
- Proteomics
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Neurology
- Clinical Neurology