Serum levels of circulating intercellular adhesion molecule 1 in hepatocellular carcinoma

Keisuke Hamazaki, Akira Gochi, Hiroshi Shimamura, Akihiko Kaihara, Yukinobu Maruo, Yoshinori Doi, Kunzo Orita, N. J. Lygidakis

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)


Background/Aims: This is a comparative study of the relationship between. Material and Methods: Serum Levels of circulating intercellular adhesion molecule-1 (cICAM-1) were measured by ELISA assay in four patients with chronic hepatitis (CH), 16 with liver cirrhosis (LC), 38 with hepatocellular carcinoma (HCC), and in nine healthy controls. Results: No significant difference in cICAM-1 levels was observed between LC and HCC. The cICAM-1 level in HCC did not correlate with tumor markers but correlated well with tumor size. cICAM-1 level in HCC Stage III + IV was significantly higher than that of Stage I, and was higher in HCC with liver metastasis as opposed to HCC without metastasis. Furthermore, the cICAM-1 level of HCC decreased significantly after hepatectomy. Conclusion: These findings showed a close relationship between cICAM-1 and the progress of intrahepatic metastasis of HCC, indicating a possibility for using cICAM-1 as a prognostic marker.

Original languageEnglish
Pages (from-to)229-234
Number of pages6
Issue number7
Publication statusPublished - 1996
Externally publishedYes


  • Circulating ICAM-1 (cICAM-1)
  • Hepatocellular carcinoma
  • ICAM-1

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


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