Serum levels of circulating intercellular adhesion molecule 1 in hepatocellular carcinoma

Keisuke Hamazaki, Akira Gochi, Hiroshi Shimamura, Akihiko Kaihara, Yukinobu Maruo, Yoshinori Doi, Kunzo Orita, N. J. Lygidakis

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18 Citations (Scopus)

Abstract

Background/Aims: This is a comparative study of the relationship between. Material and Methods: Serum Levels of circulating intercellular adhesion molecule-1 (cICAM-1) were measured by ELISA assay in four patients with chronic hepatitis (CH), 16 with liver cirrhosis (LC), 38 with hepatocellular carcinoma (HCC), and in nine healthy controls. Results: No significant difference in cICAM-1 levels was observed between LC and HCC. The cICAM-1 level in HCC did not correlate with tumor markers but correlated well with tumor size. cICAM-1 level in HCC Stage III + IV was significantly higher than that of Stage I, and was higher in HCC with liver metastasis as opposed to HCC without metastasis. Furthermore, the cICAM-1 level of HCC decreased significantly after hepatectomy. Conclusion: These findings showed a close relationship between cICAM-1 and the progress of intrahepatic metastasis of HCC, indicating a possibility for using cICAM-1 as a prognostic marker.

Original languageEnglish
Pages (from-to)229-234
Number of pages6
JournalHepato-gastroenterology
Volume43
Issue number7
Publication statusPublished - Mar 26 1996

Keywords

  • Circulating ICAM-1 (cICAM-1)
  • Hepatocellular carcinoma
  • ICAM-1

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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    Hamazaki, K., Gochi, A., Shimamura, H., Kaihara, A., Maruo, Y., Doi, Y., Orita, K., & Lygidakis, N. J. (1996). Serum levels of circulating intercellular adhesion molecule 1 in hepatocellular carcinoma. Hepato-gastroenterology, 43(7), 229-234.