Serum level of arginine-vasopressin influences the prognosis of extensive-disease small-cell lung cancer

Shigeki Umemura, Yoshihiko Segawa, Hiroshi Ueoka, Katsuyuki Hotta, Katsuyuki Kiura, Nagio Takigawa, Masahiro Tabata, Akihiro Bessho, Tetsu Shinkai, Mitsune Tanimoto

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Purpose: The purpose of this study is to elucidate the influence of serum arginine-vasopressin (AVP) level on prognosis of extensive-disease small-cell lung cancer (ED-SCLC). Methods: We retrospectively investigated the clinical records of 163 patients with ED-SCLC, who were admitted to Okayama University Hospital or National Shikoku Cancer Center Hospital. The influence of 14 pretreatment variables on survival was analyzed. Results: In a multivariate analysis of 163 patients, elevation of serum LDH level (P = 0.028) and poor performance status (PS ≥ 2, P = 0.002) were independent poor prognostic factors. In 34 patients whose serum AVP levels were available, high serum AVP level was related to the poor prognosis (P < 0.001). The serum-sodium level did not affect the survival. Median serum level of osmotic pressure in 34 patients was normal (284.9 mOsm/kg), although, serum osmotic pressure was low in four of six patients with high serum AVP level. In all patients with high serum AVP level, serum LDH level was elevated. Conclusions: The data from the current study suggested that serum LDH level and PS were the poor prognostic factors for ED-SCLC. But we additionally identified the prognostic significance of serum AVP level, which may be a more useful factor than serum-sodium level.

Original languageEnglish
Pages (from-to)519-524
Number of pages6
JournalJournal of cancer research and clinical oncology
Volume133
Issue number8
DOIs
Publication statusPublished - Aug 2007

Keywords

  • Arginin-vasopressin (AVP)
  • Osmotic pressure
  • Prognostic factor
  • Small-cell lung cancer
  • Sodium

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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