Abstract
Primary biliary cirrhosis is an autoimmune disease of the liver in which T helper 1 cytokines predominate over those of T helper 2 in the pathogenesis. Interleukin-18 (IL-18), for which the gene was recently cloned, is a novel T helper 1 cytokine, which augments interferon-gamma production. We designed this study to clarify the role of IL-18 in primary biliary cirrhosis and to examine whether serum IL-18 level can be a prognostic indicator for the disease. Serum IL-18 levels were measured using an enzyme linked immuno sorbent assay with mouse monoclonal antibodies. Twenty-two healthy volunteers, 31 patients with primary biliary cirrhosis (Scheuer's stage I, 13; II, 10; and IV, 8), 20 patients with autoimmune hepatitis, 11 patients with virus-related liver cirrhosis and six patients with obstructive jaundice were enrolled. Significant differences of serum IL-18 levels were observed between patients with Scheuer's stage IV and those with stage I, or II, virus-related liver cirrhosis and obstructive jaundice (P <0.05). The IL-18 levels in primary biliary cirrhosis increased according to the disease progression, and fell promptly after living-related liver transplantation. Moreover, serum IL-18 levels in primary biliary cirrhosis were correlated with serum bilirubin concentrations and the Risk scores of the Mayo Clinic prognostic model for the disease. The IL-18 levels observed in patients with autoimmune hepatitis were also elevated, and correlated with the activity of the disease. These results indicate that serum interleukin-18 levels reflect the severity of primary biliary cirrhosis, the activity of autoimmune hepatitis, and may be an additive prognostic indicator in primary biliary cirrhosis.
| Original language | English |
|---|---|
| Pages (from-to) | 227-231 |
| Number of pages | 5 |
| Journal | Clinical and Experimental Immunology |
| Volume | 122 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2000 |
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Keywords
- Autoimmune hepatitis
- IL-18
- Interferon-gamma-inducing factor
- Primary biliary cirrhosis
ASJC Scopus subject areas
- Immunology
Cite this
Serum interferon-gamma-inducing factor/IL-18 levels in primary biliary cirrhosis. / Yaman, T.; Higashi, T.; Nouso, K.; Nakatsukasa, H.; Kariyama, K.; Yumoto, E.; Kobayashi, Y.; Yamamoto, K.; Iwagaki, H.; Yagi, Takahito; Tanimoto, T.; Kurimoto, M.; Tanaka, N.; Tsuji, T.
In: Clinical and Experimental Immunology, Vol. 122, No. 2, 2000, p. 227-231.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Serum interferon-gamma-inducing factor/IL-18 levels in primary biliary cirrhosis
AU - Yaman, T.
AU - Higashi, T.
AU - Nouso, K.
AU - Nakatsukasa, H.
AU - Kariyama, K.
AU - Yumoto, E.
AU - Kobayashi, Y.
AU - Yamamoto, K.
AU - Iwagaki, H.
AU - Yagi, Takahito
AU - Tanimoto, T.
AU - Kurimoto, M.
AU - Tanaka, N.
AU - Tsuji, T.
PY - 2000
Y1 - 2000
N2 - Primary biliary cirrhosis is an autoimmune disease of the liver in which T helper 1 cytokines predominate over those of T helper 2 in the pathogenesis. Interleukin-18 (IL-18), for which the gene was recently cloned, is a novel T helper 1 cytokine, which augments interferon-gamma production. We designed this study to clarify the role of IL-18 in primary biliary cirrhosis and to examine whether serum IL-18 level can be a prognostic indicator for the disease. Serum IL-18 levels were measured using an enzyme linked immuno sorbent assay with mouse monoclonal antibodies. Twenty-two healthy volunteers, 31 patients with primary biliary cirrhosis (Scheuer's stage I, 13; II, 10; and IV, 8), 20 patients with autoimmune hepatitis, 11 patients with virus-related liver cirrhosis and six patients with obstructive jaundice were enrolled. Significant differences of serum IL-18 levels were observed between patients with Scheuer's stage IV and those with stage I, or II, virus-related liver cirrhosis and obstructive jaundice (P <0.05). The IL-18 levels in primary biliary cirrhosis increased according to the disease progression, and fell promptly after living-related liver transplantation. Moreover, serum IL-18 levels in primary biliary cirrhosis were correlated with serum bilirubin concentrations and the Risk scores of the Mayo Clinic prognostic model for the disease. The IL-18 levels observed in patients with autoimmune hepatitis were also elevated, and correlated with the activity of the disease. These results indicate that serum interleukin-18 levels reflect the severity of primary biliary cirrhosis, the activity of autoimmune hepatitis, and may be an additive prognostic indicator in primary biliary cirrhosis.
AB - Primary biliary cirrhosis is an autoimmune disease of the liver in which T helper 1 cytokines predominate over those of T helper 2 in the pathogenesis. Interleukin-18 (IL-18), for which the gene was recently cloned, is a novel T helper 1 cytokine, which augments interferon-gamma production. We designed this study to clarify the role of IL-18 in primary biliary cirrhosis and to examine whether serum IL-18 level can be a prognostic indicator for the disease. Serum IL-18 levels were measured using an enzyme linked immuno sorbent assay with mouse monoclonal antibodies. Twenty-two healthy volunteers, 31 patients with primary biliary cirrhosis (Scheuer's stage I, 13; II, 10; and IV, 8), 20 patients with autoimmune hepatitis, 11 patients with virus-related liver cirrhosis and six patients with obstructive jaundice were enrolled. Significant differences of serum IL-18 levels were observed between patients with Scheuer's stage IV and those with stage I, or II, virus-related liver cirrhosis and obstructive jaundice (P <0.05). The IL-18 levels in primary biliary cirrhosis increased according to the disease progression, and fell promptly after living-related liver transplantation. Moreover, serum IL-18 levels in primary biliary cirrhosis were correlated with serum bilirubin concentrations and the Risk scores of the Mayo Clinic prognostic model for the disease. The IL-18 levels observed in patients with autoimmune hepatitis were also elevated, and correlated with the activity of the disease. These results indicate that serum interleukin-18 levels reflect the severity of primary biliary cirrhosis, the activity of autoimmune hepatitis, and may be an additive prognostic indicator in primary biliary cirrhosis.
KW - Autoimmune hepatitis
KW - IL-18
KW - Interferon-gamma-inducing factor
KW - Primary biliary cirrhosis
UR - http://www.scopus.com/inward/record.url?scp=0033752165&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033752165&partnerID=8YFLogxK
U2 - 10.1046/j.1365-2249.2000.01356.x
DO - 10.1046/j.1365-2249.2000.01356.x
M3 - Article
C2 - 11091279
AN - SCOPUS:0033752165
VL - 122
SP - 227
EP - 231
JO - Clinical and Experimental Immunology
JF - Clinical and Experimental Immunology
SN - 0009-9104
IS - 2
ER -