Serum gamma-interferon-inducing factor (IL-18) and IL-10 levels in patients with acute hepatitis and fulminant hepatic failure

Eiichiro Yumoto, Toshihiro Higashi, Kazuhiro Nouso, Harushige Nakatsukasa, Keishi Fujiwara, Tadashi Hanafusa, Yasuhiro Yumoto, Tadao Tanimoto, Masashi Kurimoto, Noriaki Tanaka, Takao Tsuji

Research output: Contribution to journalArticle

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Abstract

Background and Aims: The aim was to determine the role of T-helper (Th)1/Th2 cytokine responses in the clinical outcome of patients with acute liver injury. Methods: The serum levels of the cytokines, interleukin (IL)-18, gamma-interferon (IFN-γ), IL-10 and IL-4 were measured in 20 fulminant hepatic failure (FHF), 18 acute hepatitis (AH), 30 chronic viral hepatitis and 20 liver cirrhosis (LC) patients. Thirteen cases were from the intensive care unit (ICU) and there were 21 healthy volunteers. Immunohistochemical staining of liver biopsies for IL-18 expression was also performed. Results: Serum IL-18 levels in patients with FHF were significantly more elevated than in patients with other liver diseases, ICU cases and healthy volunteers. Furthermore, serum IFN-γ levels in patients with FHF were also significantly higher than in patients with chronic viral hepatitis, LC and healthy volunteers. We found a positive correlation between the levels of IL-18 and IFN-γ. However, no relationship was observed between these and clinical outcome. In immunohistochemical staining, CD68+ macrophage cells and IL-18-positive cells were observed in portal zones. Elevated serum IL-10 levels were restricted to patients presenting with FHF, and were significantly higher in surviving cases (P <0.01). Furthermore, serum IL-10 levels, but not IL-4 levels, were inversely correlated with serum total bilirubin concentrations (P=0.045) and the death rate (p) outlined in Japan (P=0.030). Conclusion: These results suggest that IL-18 and IFN-γ are involved in the pathogenesis of acute hepatic injury in humans, and that, in particular, elevated serum levels of IL-10 may be predictive of improved outcomes for these patients.

Original languageEnglish
Pages (from-to)285-294
Number of pages10
JournalJournal of Gastroenterology and Hepatology (Australia)
Volume17
Issue number3
DOIs
Publication statusPublished - 2002

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Interleukin-18
Acute Liver Failure
Interleukin-10
Hepatitis
Serum
Healthy Volunteers
Chronic Hepatitis
Interleukin-4
Liver Cirrhosis
Intensive Care Units
Liver
Staining and Labeling
Cytokines
Wounds and Injuries
Bilirubin
Interferon-gamma
Liver Diseases
Japan
Macrophages
Biopsy

Keywords

  • Fulminant hepatic failure
  • IFN-γ
  • IL-10
  • IL-18
  • Prognosis

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

Cite this

Serum gamma-interferon-inducing factor (IL-18) and IL-10 levels in patients with acute hepatitis and fulminant hepatic failure. / Yumoto, Eiichiro; Higashi, Toshihiro; Nouso, Kazuhiro; Nakatsukasa, Harushige; Fujiwara, Keishi; Hanafusa, Tadashi; Yumoto, Yasuhiro; Tanimoto, Tadao; Kurimoto, Masashi; Tanaka, Noriaki; Tsuji, Takao.

In: Journal of Gastroenterology and Hepatology (Australia), Vol. 17, No. 3, 2002, p. 285-294.

Research output: Contribution to journalArticle

Yumoto, E, Higashi, T, Nouso, K, Nakatsukasa, H, Fujiwara, K, Hanafusa, T, Yumoto, Y, Tanimoto, T, Kurimoto, M, Tanaka, N & Tsuji, T 2002, 'Serum gamma-interferon-inducing factor (IL-18) and IL-10 levels in patients with acute hepatitis and fulminant hepatic failure', Journal of Gastroenterology and Hepatology (Australia), vol. 17, no. 3, pp. 285-294. https://doi.org/10.1046/j.1440-1746.2002.02690.x
Yumoto, Eiichiro ; Higashi, Toshihiro ; Nouso, Kazuhiro ; Nakatsukasa, Harushige ; Fujiwara, Keishi ; Hanafusa, Tadashi ; Yumoto, Yasuhiro ; Tanimoto, Tadao ; Kurimoto, Masashi ; Tanaka, Noriaki ; Tsuji, Takao. / Serum gamma-interferon-inducing factor (IL-18) and IL-10 levels in patients with acute hepatitis and fulminant hepatic failure. In: Journal of Gastroenterology and Hepatology (Australia). 2002 ; Vol. 17, No. 3. pp. 285-294.
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AU - Yumoto, Eiichiro

AU - Higashi, Toshihiro

AU - Nouso, Kazuhiro

AU - Nakatsukasa, Harushige

AU - Fujiwara, Keishi

AU - Hanafusa, Tadashi

AU - Yumoto, Yasuhiro

AU - Tanimoto, Tadao

AU - Kurimoto, Masashi

AU - Tanaka, Noriaki

AU - Tsuji, Takao

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N2 - Background and Aims: The aim was to determine the role of T-helper (Th)1/Th2 cytokine responses in the clinical outcome of patients with acute liver injury. Methods: The serum levels of the cytokines, interleukin (IL)-18, gamma-interferon (IFN-γ), IL-10 and IL-4 were measured in 20 fulminant hepatic failure (FHF), 18 acute hepatitis (AH), 30 chronic viral hepatitis and 20 liver cirrhosis (LC) patients. Thirteen cases were from the intensive care unit (ICU) and there were 21 healthy volunteers. Immunohistochemical staining of liver biopsies for IL-18 expression was also performed. Results: Serum IL-18 levels in patients with FHF were significantly more elevated than in patients with other liver diseases, ICU cases and healthy volunteers. Furthermore, serum IFN-γ levels in patients with FHF were also significantly higher than in patients with chronic viral hepatitis, LC and healthy volunteers. We found a positive correlation between the levels of IL-18 and IFN-γ. However, no relationship was observed between these and clinical outcome. In immunohistochemical staining, CD68+ macrophage cells and IL-18-positive cells were observed in portal zones. Elevated serum IL-10 levels were restricted to patients presenting with FHF, and were significantly higher in surviving cases (P <0.01). Furthermore, serum IL-10 levels, but not IL-4 levels, were inversely correlated with serum total bilirubin concentrations (P=0.045) and the death rate (p) outlined in Japan (P=0.030). Conclusion: These results suggest that IL-18 and IFN-γ are involved in the pathogenesis of acute hepatic injury in humans, and that, in particular, elevated serum levels of IL-10 may be predictive of improved outcomes for these patients.

AB - Background and Aims: The aim was to determine the role of T-helper (Th)1/Th2 cytokine responses in the clinical outcome of patients with acute liver injury. Methods: The serum levels of the cytokines, interleukin (IL)-18, gamma-interferon (IFN-γ), IL-10 and IL-4 were measured in 20 fulminant hepatic failure (FHF), 18 acute hepatitis (AH), 30 chronic viral hepatitis and 20 liver cirrhosis (LC) patients. Thirteen cases were from the intensive care unit (ICU) and there were 21 healthy volunteers. Immunohistochemical staining of liver biopsies for IL-18 expression was also performed. Results: Serum IL-18 levels in patients with FHF were significantly more elevated than in patients with other liver diseases, ICU cases and healthy volunteers. Furthermore, serum IFN-γ levels in patients with FHF were also significantly higher than in patients with chronic viral hepatitis, LC and healthy volunteers. We found a positive correlation between the levels of IL-18 and IFN-γ. However, no relationship was observed between these and clinical outcome. In immunohistochemical staining, CD68+ macrophage cells and IL-18-positive cells were observed in portal zones. Elevated serum IL-10 levels were restricted to patients presenting with FHF, and were significantly higher in surviving cases (P <0.01). Furthermore, serum IL-10 levels, but not IL-4 levels, were inversely correlated with serum total bilirubin concentrations (P=0.045) and the death rate (p) outlined in Japan (P=0.030). Conclusion: These results suggest that IL-18 and IFN-γ are involved in the pathogenesis of acute hepatic injury in humans, and that, in particular, elevated serum levels of IL-10 may be predictive of improved outcomes for these patients.

KW - Fulminant hepatic failure

KW - IFN-γ

KW - IL-10

KW - IL-18

KW - Prognosis

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