Serum galectin-9 levels are elevated in the patients with type 2 diabetes and chronic kidney disease

Yuko Kurose, Jun Wada, Motoko Kanzaki, Sanae Teshigawara, Atsuko Nakatsuka, Kazutoshi Murakami, Kentaro Inoue, Takahiro Terami, Akihiro Katayama, Mayu Watanabe, Chigusa Higuchi, Jun Eguchi, Nobuyuki Miyatake, Hirofumi Makino

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Background: Galectin-9 (Gal-9) induces apoptosis in activated T helper 1 (T§ssub§H§esub§1) cells as a ligand for T cell immunoglobulin mucin-3 (Tim-3). Gal-9 also inhibits the G1 phase cell cycle arrest and hypertrophy in db/db mice, the hallmark of early diabetic nephropathy, by reversing the high glucose-induced up-regulation of cyclin dependent kinase inhibitors such as p27§ssup§Kip1§esup§ and p21§ssup§Cip1§esup§. Methods. We investigated the serum levels of Gal-9 in the patients with type 2 diabetes and various stages of chronic kidney disease (CKD) (n=182). Results: Serum Gal-9 levels in the patients with type 2 diabetes were 131.9 ± 105.4 pg/ml and Log§ssub§10§esub§Gal-9 levels significantly and positively correlated with age (r=0.227, p=0.002), creatinine (r=0.175, p=0.018), urea nitrogen (r=0.162, p=0.028) and osmotic pressure (r=0.187, p=0.014) and negatively correlated with estimated glomerular filtration rate (eGFR) (r=-0.188, p=0.011). Log§ssub§10§esub§Gal-9 levels increased along with the progression of GFR categories of G1 to G4, and they were statistically significant by Jonckheere-Terpstra test (p=0.012). Log§ssub§10§esub§Gal-9 levels remained similar levels in albuminuria stages of A1 to A3. Conclusion: The elevation of serum Gal-9 in the patients with type 2 diabetes is closely linked to GFR and they may be related to the alteration of the immune response and inflammation of the patients with type 2 diabetes and CKD.

Original languageEnglish
Article number23
JournalBMC nephrology
Volume14
Issue number1
DOIs
Publication statusPublished - 2013

Keywords

  • Glomerular filtration
  • Inflammation
  • Kidney disease
  • Nephropathy
  • Type 2 diabetes

ASJC Scopus subject areas

  • Nephrology

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