Serum cystatin C as a biomarker of cardiac diastolic dysfunction in patients with cardiac disease and preserved ejection fraction

Kazumasa Nosaka, Kazufumi Nakamura, Kengo Kusano, Norihisa Toh, Takeshi Tada, Toru Miyoshi, Masayuki Doi, Kunihisa Kohno, Hiroshi Morita, Hiroshi Itoh

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Diastolic dysfunction of the heart is correlated with cardiac mortality. Serum cystatin C (CysC) is an endogenous marker of kidney function. It is not clear whether serum CysC is associated with diastolic dysfunction in patients with varying cardiac conditions with concomitant diastolic abnormalities and preserved ejection fraction (EF). The authors measured serum CysC levels in patients with cardiac diseases and examined the relationships between serum CysC levels and diastolic function. Serum CysC was measured and echocardiography was performed in 124 consecutive patients with cardiac diseases. Transmitral flow (TMF) patterns surrogating diastolic function were categorized into two groups: a normal group and an abnormal group. Serum CysC and BNP showed a significant positive correlation. There were no significant differences in serum CysC among those cardiac diseases. Seventy-eight patients with cardiac disease and preserved EF (left ventricular EF ≥50%) and without renal dysfunction (estimated glomerular filtration rate ≥60 mL/minute/1.73 m2) were examined. Multivariate linear regression analysis demonstrated that left atrium diameter and abnormal TMF patterns were independent determinants of serum CysC. Furthermore, patients with elevated serum CysC levels had poor prognosis. Serum CysC is associated with diastolic dysfunction in patients with various cardiac diseases and preserved EF. Serum CysC might be a biomarker of cardiac diastolic dysfunction in patients with preserved EF.

Original languageEnglish
JournalCongestive Heart Failure
Volume19
Issue number4
DOIs
Publication statusPublished - Jul 2013

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Cystatin C
Heart Diseases
Biomarkers
Serum
Kidney
Heart Atria
Glomerular Filtration Rate
Stroke Volume
Echocardiography
Linear Models
Regression Analysis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Emergency Medicine
  • Emergency

Cite this

Serum cystatin C as a biomarker of cardiac diastolic dysfunction in patients with cardiac disease and preserved ejection fraction. / Nosaka, Kazumasa; Nakamura, Kazufumi; Kusano, Kengo; Toh, Norihisa; Tada, Takeshi; Miyoshi, Toru; Doi, Masayuki; Kohno, Kunihisa; Morita, Hiroshi; Itoh, Hiroshi.

In: Congestive Heart Failure, Vol. 19, No. 4, 07.2013.

Research output: Contribution to journalArticle

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AU - Tada, Takeshi

AU - Miyoshi, Toru

AU - Doi, Masayuki

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