Abstract
Previous studies have reported the existence of an association between brain-derived neurotrophic factor and major depression. However, the possible role of brain-derived neurotrophic factor in the pathophysiology of major depression after cancer diagnosis has not yet been investigated. Subjects were collected using the Lung Cancer Database project. Using the cut-off scores on the depression subscale of the Hospital Anxiety and Depression Scale (HADS-D), 81 subjects with depression (HADS-D > 10) and 81 subjects without depression (HADS-D <5) were selected. The two groups were matched for age, sex, clinical stage and performance status. The serum brain-derived neurotrophic factor levels were measured using an enzyme-linked immunosorbent assay method. The serum brain-derived neurotrophic factor levels were not statistically different between the subjects in the depression group [29.1 (13.6) ng/ml; mean (SD)] and the non-depression group [31.4 (10.6) ng/ml] (P = 0.22). In a stratified analysis by gender, however, the mean serum brain-derived neurotrophic factor level in the depression group tended to be lower than that in the non-depression group among women (n = 24 pairs, P = 0.06). Major depression after cancer diagnosis is not associated with serum brain-derived neurotrophic factor levels.
| Original language | English |
|---|---|
| Article number | hyr119 |
| Pages (from-to) | 1233-1237 |
| Number of pages | 5 |
| Journal | Japanese Journal of Clinical Oncology |
| Volume | 41 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - Oct 2011 |
| Externally published | Yes |
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Keywords
- BDNF
- Cancer diagnosis
- Lung cancer
- Major depression
- Stressful event
ASJC Scopus subject areas
- Oncology
- Cancer Research
- Radiology Nuclear Medicine and imaging
Cite this
Serum brain-derived neurotrophic factor and antidepressant-naive major depression after lung cancer diagnosis. / Kobayakawa, Makoto; Inagaki, Masatoshi; Fujimori, Maiko; Hamazaki, Kei; Hamazaki, Tomohito; Akechi, Tatsuo; Tsugane, Shoichiro; Nishiwaki, Yutaka; Goto, Koichi; Hashimoto, Kenji; Yamawaki, Shigeto; Uchitomi, Yosuke.
In: Japanese Journal of Clinical Oncology, Vol. 41, No. 10, hyr119, 10.2011, p. 1233-1237.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Serum brain-derived neurotrophic factor and antidepressant-naive major depression after lung cancer diagnosis
AU - Kobayakawa, Makoto
AU - Inagaki, Masatoshi
AU - Fujimori, Maiko
AU - Hamazaki, Kei
AU - Hamazaki, Tomohito
AU - Akechi, Tatsuo
AU - Tsugane, Shoichiro
AU - Nishiwaki, Yutaka
AU - Goto, Koichi
AU - Hashimoto, Kenji
AU - Yamawaki, Shigeto
AU - Uchitomi, Yosuke
PY - 2011/10
Y1 - 2011/10
N2 - Previous studies have reported the existence of an association between brain-derived neurotrophic factor and major depression. However, the possible role of brain-derived neurotrophic factor in the pathophysiology of major depression after cancer diagnosis has not yet been investigated. Subjects were collected using the Lung Cancer Database project. Using the cut-off scores on the depression subscale of the Hospital Anxiety and Depression Scale (HADS-D), 81 subjects with depression (HADS-D > 10) and 81 subjects without depression (HADS-D <5) were selected. The two groups were matched for age, sex, clinical stage and performance status. The serum brain-derived neurotrophic factor levels were measured using an enzyme-linked immunosorbent assay method. The serum brain-derived neurotrophic factor levels were not statistically different between the subjects in the depression group [29.1 (13.6) ng/ml; mean (SD)] and the non-depression group [31.4 (10.6) ng/ml] (P = 0.22). In a stratified analysis by gender, however, the mean serum brain-derived neurotrophic factor level in the depression group tended to be lower than that in the non-depression group among women (n = 24 pairs, P = 0.06). Major depression after cancer diagnosis is not associated with serum brain-derived neurotrophic factor levels.
AB - Previous studies have reported the existence of an association between brain-derived neurotrophic factor and major depression. However, the possible role of brain-derived neurotrophic factor in the pathophysiology of major depression after cancer diagnosis has not yet been investigated. Subjects were collected using the Lung Cancer Database project. Using the cut-off scores on the depression subscale of the Hospital Anxiety and Depression Scale (HADS-D), 81 subjects with depression (HADS-D > 10) and 81 subjects without depression (HADS-D <5) were selected. The two groups were matched for age, sex, clinical stage and performance status. The serum brain-derived neurotrophic factor levels were measured using an enzyme-linked immunosorbent assay method. The serum brain-derived neurotrophic factor levels were not statistically different between the subjects in the depression group [29.1 (13.6) ng/ml; mean (SD)] and the non-depression group [31.4 (10.6) ng/ml] (P = 0.22). In a stratified analysis by gender, however, the mean serum brain-derived neurotrophic factor level in the depression group tended to be lower than that in the non-depression group among women (n = 24 pairs, P = 0.06). Major depression after cancer diagnosis is not associated with serum brain-derived neurotrophic factor levels.
KW - BDNF
KW - Cancer diagnosis
KW - Lung cancer
KW - Major depression
KW - Stressful event
UR - http://www.scopus.com/inward/record.url?scp=80053501842&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80053501842&partnerID=8YFLogxK
U2 - 10.1093/jjco/hyr119
DO - 10.1093/jjco/hyr119
M3 - Article
VL - 41
SP - 1233
EP - 1237
JO - Japanese Journal of Clinical Oncology
JF - Japanese Journal of Clinical Oncology
SN - 0368-2811
IS - 10
M1 - hyr119
ER -