Serum brain-derived neurotrophic factor and antidepressant-naive major depression after lung cancer diagnosis

Makoto Kobayakawa, Masatoshi Inagaki, Maiko Fujimori, Kei Hamazaki, Tomohito Hamazaki, Tatsuo Akechi, Shoichiro Tsugane, Yutaka Nishiwaki, Koichi Goto, Kenji Hashimoto, Shigeto Yamawaki, Yosuke Uchitomi

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7 Citations (Scopus)

Abstract

Previous studies have reported the existence of an association between brain-derived neurotrophic factor and major depression. However, the possible role of brain-derived neurotrophic factor in the pathophysiology of major depression after cancer diagnosis has not yet been investigated. Subjects were collected using the Lung Cancer Database project. Using the cut-off scores on the depression subscale of the Hospital Anxiety and Depression Scale (HADS-D), 81 subjects with depression (HADS-D > 10) and 81 subjects without depression (HADS-D < 5) were selected. The two groups were matched for age, sex, clinical stage and performance status. The serum brain-derived neurotrophic factor levels were measured using an enzyme-linked immunosorbent assay method. The serum brain-derived neurotrophic factor levels were not statistically different between the subjects in the depression group [29.1 (13.6) ng/ml; mean (SD)] and the non-depression group [31.4 (10.6) ng/ml] (P = 0.22). In a stratified analysis by gender, however, the mean serum brain-derived neurotrophic factor level in the depression group tended to be lower than that in the non-depression group among women (n = 24 pairs, P = 0.06). Major depression after cancer diagnosis is not associated with serum brain-derived neurotrophic factor levels.

Original languageEnglish
Article numberhyr119
Pages (from-to)1233-1237
Number of pages5
JournalJapanese journal of clinical oncology
Volume41
Issue number10
DOIs
Publication statusPublished - Oct 2011
Externally publishedYes

Keywords

  • BDNF
  • Cancer diagnosis
  • Lung cancer
  • Major depression
  • Stressful event

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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  • Cite this

    Kobayakawa, M., Inagaki, M., Fujimori, M., Hamazaki, K., Hamazaki, T., Akechi, T., Tsugane, S., Nishiwaki, Y., Goto, K., Hashimoto, K., Yamawaki, S., & Uchitomi, Y. (2011). Serum brain-derived neurotrophic factor and antidepressant-naive major depression after lung cancer diagnosis. Japanese journal of clinical oncology, 41(10), 1233-1237. [hyr119]. https://doi.org/10.1093/jjco/hyr119