Serum bFGF levels are reduced in Japanese overweight men and restored by a 6-month exercise education

A. Seida, Jun Wada, M. Kunitomi, Y. Tsuchiyama, N. Miyatake, M. Fujii, S. Kira, Kayo Takahashi, Kenichi Shikata, Hirofumi Makino

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

OBJECTIVE: To investigate whether the changes in vascular endothelial growth factor (VECF) and basic fibroblast growth factor (bFCF) concentrations before and after weight reduction in Japanese overweight men are associated with changes in body mass index (BMI), visceral, subcutaneous fat, VO 2 and work rate (WR) at ventilatory threshold (VT). DESIGN: Cross-sectional and longitudinal clinical intervention study with exercise education. SUBJECTS: In total, 30 Japanese overweight men (BMI, 29.0 ± 2.2 kg/m2) and 31 normal-weight men (BMI, 22.5 ± 1.6 kg/m 2) at baseline were enrolled: 30 overweight men (BMI, 29.0 ± 2.2 kg/m2) were further enrolled into a 6-month exercise program. MEASUREMENTS: Fat distribution evaluated by visceral fat (V) and subcutaneous fat (S) areas measured with computed tomography scanning at umbilical levels, angiogenic peptides including VECF and bFCF, exercise tests at baseline and after 6 months. RESULTS: In normal-weight and overweight subjects at baseline, VEGF positively correlated with S area (r = 0.350, P = 0.007) but not with V area. In contrast, bFCF negatively correlated with BMI (r = -0.619, P2 and WR at VT, increase in bFGF (9.21 ± 5.82-21.2 ± 7.04 ng/ ml, P2 (β = 2.806) were independently related to ΔbFCF (P2 with ΔbFCF after exercise intervention. The exercise-induced elevation of bFCF may be beneficial in the prevention of the atherosclerosis in overweight subjects.

Original languageEnglish
Pages (from-to)1325-1331
Number of pages7
JournalInternational Journal of Obesity
Volume27
Issue number11
DOIs
Publication statusPublished - Nov 2003

Fingerprint

body mass index
education
exercise
Body Mass Index
Exercise
Education
Serum
Intra-Abdominal Fat
Subcutaneous Fat
subcutaneous fat
Vascular Endothelial Growth Factor A
Angiogenic Proteins
umbilicus
Umbilicus
Weights and Measures
fibroblast growth factor 2
visceral fat
exercise test
vascular endothelial growth factors
Fibroblast Growth Factor 2

Keywords

  • Angiogenesis
  • Atherosclerosis
  • Basic fibroblast growth factor
  • Exercise
  • Vascular endothelial growth factor

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Public Health, Environmental and Occupational Health
  • Endocrinology
  • Food Science
  • Endocrinology, Diabetes and Metabolism

Cite this

Serum bFGF levels are reduced in Japanese overweight men and restored by a 6-month exercise education. / Seida, A.; Wada, Jun; Kunitomi, M.; Tsuchiyama, Y.; Miyatake, N.; Fujii, M.; Kira, S.; Takahashi, Kayo; Shikata, Kenichi; Makino, Hirofumi.

In: International Journal of Obesity, Vol. 27, No. 11, 11.2003, p. 1325-1331.

Research output: Contribution to journalArticle

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AU - Wada, Jun

AU - Kunitomi, M.

AU - Tsuchiyama, Y.

AU - Miyatake, N.

AU - Fujii, M.

AU - Kira, S.

AU - Takahashi, Kayo

AU - Shikata, Kenichi

AU - Makino, Hirofumi

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AB - OBJECTIVE: To investigate whether the changes in vascular endothelial growth factor (VECF) and basic fibroblast growth factor (bFCF) concentrations before and after weight reduction in Japanese overweight men are associated with changes in body mass index (BMI), visceral, subcutaneous fat, VO 2 and work rate (WR) at ventilatory threshold (VT). DESIGN: Cross-sectional and longitudinal clinical intervention study with exercise education. SUBJECTS: In total, 30 Japanese overweight men (BMI, 29.0 ± 2.2 kg/m2) and 31 normal-weight men (BMI, 22.5 ± 1.6 kg/m 2) at baseline were enrolled: 30 overweight men (BMI, 29.0 ± 2.2 kg/m2) were further enrolled into a 6-month exercise program. MEASUREMENTS: Fat distribution evaluated by visceral fat (V) and subcutaneous fat (S) areas measured with computed tomography scanning at umbilical levels, angiogenic peptides including VECF and bFCF, exercise tests at baseline and after 6 months. RESULTS: In normal-weight and overweight subjects at baseline, VEGF positively correlated with S area (r = 0.350, P = 0.007) but not with V area. In contrast, bFCF negatively correlated with BMI (r = -0.619, P2 and WR at VT, increase in bFGF (9.21 ± 5.82-21.2 ± 7.04 ng/ ml, P2 (β = 2.806) were independently related to ΔbFCF (P2 with ΔbFCF after exercise intervention. The exercise-induced elevation of bFCF may be beneficial in the prevention of the atherosclerosis in overweight subjects.

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