Serum anti-p53 antibody as a tumour marker for colorectal cancer screening

Masaya Iwamuro, Yoshinari Kawai, Tomoko Matsumoto, Masashi Uda, Hiroyuki Okada

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A 60-year-old Japanese man presented to our hospital for further investigation of an elevated serum anti-p53 antibody level. He was diagnosed with colon cancer and the tumour was surgically resected. Histological diagnosis of advanced colon cancer without lymph node involvement or distant metastasis was made. It was noteworthy that both serum carcinoembryonic antigen (CEA) and a fecal occult blood test that were performed preoperatively were non-diagnostic. This case highlights the potential usefulness of serum anti-p53 antibody tests for detection of colorectal cancers. Moreover, sequential changes in the anti-p53 antibody levels after curative resection were observed.

Original languageEnglish
Article number560
Journalecancermedicalscience
Volume9
DOIs
Publication statusPublished - Jul 29 2015

Keywords

  • Anti-p53 antibody
  • Cancer screening tests
  • Colon cancers
  • Colorectal carcinoma
  • Early diagnosis of cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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