Serratezomines D and E, new Lycopodium alkaloids from Lycopodium serratum var. serratum

Takaaki Kubota, Hiroko Yahata, Sunao Yamamoto, Shigeki Hayashi, Toshiro Shibata, Jun'ichi Kobayashi

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

Two new Lycopodium alkaloids, serratezomines D (1) and E (2), were isolated from the club moss Lycopodium serratum var. serratum. Serratezomine D (1) is a new lucidine-type alkaloid, while serratezomine E (2) is a new phlegmarane-type alkaloid. The structures and relative stereochemistry of 1 and 2 were elucidated on the basis of spectroscopic data. Serratezomine D (1) exhibited an inhibitory activity against acetylcholinesterase.

Original languageEnglish
Pages (from-to)3577-3580
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume19
Issue number13
DOIs
Publication statusPublished - Jul 1 2009
Externally publishedYes

Keywords

  • Acetylcholinesterase
  • Lycopodium alkaloids
  • Serratezomines D and E

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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