Seroprevalence of Filovirus Infection of Rousettus aegyptiacus Bats in Zambia

Katendi Changula, Masahiro Kajihara, Akina Mori-Kajihara, Yoshiki Eto, Hiroko Miyamoto, Reiko Yoshida, Asako Shigeno, Bernard Hang'ombe, Yongjin Qiu, Daniel Mwizabi, David Squarre, Joseph Ndebe, Hirohito Ogawa, Hayato Harima, Edgar Simulundu, Ladslav Moonga, Penjaninge Kapila, Wakako Furuyama, Tatsunari Kondoh, Masahiro Sato & 6 others Yoshihiro Takadate, Chiho Kaneko, Ryo Nakao, Victor Mukonka, Aaron Mweene, Ayato Takada

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Bats are suspected to play important roles in the ecology of filoviruses, including ebolaviruses and marburgviruses. A cave-dwelling fruit bat, Rousettus aegyptiacus, has been shown to be a reservoir of marburgviruses. Using an enzyme-linked immunosorbent assay with the viral glycoprotein antigen, we detected immunoglobulin G antibodies specific to multiple filoviruses in 158 of 290 serum samples of R aegyptiacus bats captured in Zambia during the years 2014-2017. In particular, 43.8% of the bats were seropositive to marburgvirus, supporting the notion that this bat species continuously maintains marburgviruses as a reservoir. Of note, distinct peaks of seropositive rates were repeatedly observed at the beginning of rainy seasons, suggesting seasonality of the presence of newly infected individuals in this bat population. These data highlight the need for continued monitoring of filovirus infection in this bat species even in countries where filovirus diseases have not been reported.

Original languageEnglish
JournalJournal of Infectious Diseases
DOIs
Publication statusE-pub ahead of print - Jun 8 2018

Fingerprint

Zambia
Seroepidemiologic Studies
Marburgvirus
Infection
Ebolavirus
Viral Antigens
Ecology
Fruit
Glycoproteins
Immunoglobulin G
Enzyme-Linked Immunosorbent Assay
Antibodies

Cite this

Changula, K., Kajihara, M., Mori-Kajihara, A., Eto, Y., Miyamoto, H., Yoshida, R., ... Takada, A. (2018). Seroprevalence of Filovirus Infection of Rousettus aegyptiacus Bats in Zambia. Journal of Infectious Diseases. https://doi.org/10.1093/infdis/jiy266

Seroprevalence of Filovirus Infection of Rousettus aegyptiacus Bats in Zambia. / Changula, Katendi; Kajihara, Masahiro; Mori-Kajihara, Akina; Eto, Yoshiki; Miyamoto, Hiroko; Yoshida, Reiko; Shigeno, Asako; Hang'ombe, Bernard; Qiu, Yongjin; Mwizabi, Daniel; Squarre, David; Ndebe, Joseph; Ogawa, Hirohito; Harima, Hayato; Simulundu, Edgar; Moonga, Ladslav; Kapila, Penjaninge; Furuyama, Wakako; Kondoh, Tatsunari; Sato, Masahiro; Takadate, Yoshihiro; Kaneko, Chiho; Nakao, Ryo; Mukonka, Victor; Mweene, Aaron; Takada, Ayato.

In: Journal of Infectious Diseases, 08.06.2018.

Research output: Contribution to journalArticle

Changula, K, Kajihara, M, Mori-Kajihara, A, Eto, Y, Miyamoto, H, Yoshida, R, Shigeno, A, Hang'ombe, B, Qiu, Y, Mwizabi, D, Squarre, D, Ndebe, J, Ogawa, H, Harima, H, Simulundu, E, Moonga, L, Kapila, P, Furuyama, W, Kondoh, T, Sato, M, Takadate, Y, Kaneko, C, Nakao, R, Mukonka, V, Mweene, A & Takada, A 2018, 'Seroprevalence of Filovirus Infection of Rousettus aegyptiacus Bats in Zambia', Journal of Infectious Diseases. https://doi.org/10.1093/infdis/jiy266
Changula, Katendi ; Kajihara, Masahiro ; Mori-Kajihara, Akina ; Eto, Yoshiki ; Miyamoto, Hiroko ; Yoshida, Reiko ; Shigeno, Asako ; Hang'ombe, Bernard ; Qiu, Yongjin ; Mwizabi, Daniel ; Squarre, David ; Ndebe, Joseph ; Ogawa, Hirohito ; Harima, Hayato ; Simulundu, Edgar ; Moonga, Ladslav ; Kapila, Penjaninge ; Furuyama, Wakako ; Kondoh, Tatsunari ; Sato, Masahiro ; Takadate, Yoshihiro ; Kaneko, Chiho ; Nakao, Ryo ; Mukonka, Victor ; Mweene, Aaron ; Takada, Ayato. / Seroprevalence of Filovirus Infection of Rousettus aegyptiacus Bats in Zambia. In: Journal of Infectious Diseases. 2018.
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AU - Eto, Yoshiki

AU - Miyamoto, Hiroko

AU - Yoshida, Reiko

AU - Shigeno, Asako

AU - Hang'ombe, Bernard

AU - Qiu, Yongjin

AU - Mwizabi, Daniel

AU - Squarre, David

AU - Ndebe, Joseph

AU - Ogawa, Hirohito

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AU - Kondoh, Tatsunari

AU - Sato, Masahiro

AU - Takadate, Yoshihiro

AU - Kaneko, Chiho

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AB - Bats are suspected to play important roles in the ecology of filoviruses, including ebolaviruses and marburgviruses. A cave-dwelling fruit bat, Rousettus aegyptiacus, has been shown to be a reservoir of marburgviruses. Using an enzyme-linked immunosorbent assay with the viral glycoprotein antigen, we detected immunoglobulin G antibodies specific to multiple filoviruses in 158 of 290 serum samples of R aegyptiacus bats captured in Zambia during the years 2014-2017. In particular, 43.8% of the bats were seropositive to marburgvirus, supporting the notion that this bat species continuously maintains marburgviruses as a reservoir. Of note, distinct peaks of seropositive rates were repeatedly observed at the beginning of rainy seasons, suggesting seasonality of the presence of newly infected individuals in this bat population. These data highlight the need for continued monitoring of filovirus infection in this bat species even in countries where filovirus diseases have not been reported.

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