Serologic factors in early relapse of IgG4-related orbital inflammation after steroid treatment

Toshinobu Kubota, Masao Katayama, Suzuko Moritani, Tadashi Yoshino

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12 Citations (Scopus)

Abstract

Purpose: To determine whether serologic factors correlate with early relapse in cases of IgG4-related orbital inflammation, a lymphoproliferative disorder. Design: Retrospective cohort study. Methods: We examined the orbital images and serum data of 30 patients with (n = 24) or without (n = 6) corticosteroid treatment before and after corticosteroid treatment and 6 months after discontinuation of corticosteroid treatment. Results: Seven patients (23%) (all with corticosteroid treatment) had elevated serum levels of rheumatoid factor. Of the 24 patients with corticosteroid treatment, 24 (100%) showed regression of the lesion, but 8 of the 24 (33%) showed relapse. The serum IgG4 levels before and after corticosteroid treatment were not significantly different between the relapsed and nonrelapsed groups (P =.5 and P =.2, respectively). However, the incidence of patients who were rheumatoid factor-positive was significantly higher in the relapsed group (P =.02). The 6 patients without corticosteroid treatment showed minor proliferation or regression of the lesion at the 6-month follow-up. Conclusions: The serum rheumatoid factor level may correlate with proliferative activity in IgG4-related orbital inflammation.

Original languageEnglish
JournalAmerican Journal of Ophthalmology
Volume155
Issue number2
DOIs
Publication statusPublished - Feb 2013

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Adrenal Cortex Hormones
Immunoglobulin G
Steroids
Inflammation
Recurrence
Rheumatoid Factor
Serum
Therapeutics
Lymphoproliferative Disorders
Cohort Studies
Retrospective Studies
Incidence

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Serologic factors in early relapse of IgG4-related orbital inflammation after steroid treatment. / Kubota, Toshinobu; Katayama, Masao; Moritani, Suzuko; Yoshino, Tadashi.

In: American Journal of Ophthalmology, Vol. 155, No. 2, 02.2013.

Research output: Contribution to journalArticle

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N2 - Purpose: To determine whether serologic factors correlate with early relapse in cases of IgG4-related orbital inflammation, a lymphoproliferative disorder. Design: Retrospective cohort study. Methods: We examined the orbital images and serum data of 30 patients with (n = 24) or without (n = 6) corticosteroid treatment before and after corticosteroid treatment and 6 months after discontinuation of corticosteroid treatment. Results: Seven patients (23%) (all with corticosteroid treatment) had elevated serum levels of rheumatoid factor. Of the 24 patients with corticosteroid treatment, 24 (100%) showed regression of the lesion, but 8 of the 24 (33%) showed relapse. The serum IgG4 levels before and after corticosteroid treatment were not significantly different between the relapsed and nonrelapsed groups (P =.5 and P =.2, respectively). However, the incidence of patients who were rheumatoid factor-positive was significantly higher in the relapsed group (P =.02). The 6 patients without corticosteroid treatment showed minor proliferation or regression of the lesion at the 6-month follow-up. Conclusions: The serum rheumatoid factor level may correlate with proliferative activity in IgG4-related orbital inflammation.

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