TY - JOUR
T1 - Sequential generation of cytokines during the initiative phase of inflammation, with reference to neutrophils
AU - Matsukawa, A.
AU - Yoshinaga, M.
PY - 1998
Y1 - 1998
N2 - Studies have suggested the role of cytokines in inflammation, as determined by results obtained in vitro, or with assessments of clinical samples. However, extrapolation of in vitro results to an in vivo situation must be made with caution, and findings obtained from clinical samples tend to lack a causal relation between cytokines and inflammatory responses. Animal models of inflammation can be useful in understanding roles of cytokines at sites of inflammation. We examined the production kinetics and cellular sources of tumor necrosis factor alpha (TNFα), interleukin (IL)-1β, IL-8, and IL-1 receptor antagonist (IL-1Ra), and obtained evidence for the involvement of these cytokines in a rabbit model of arthritis induced by lipopolysaccharide (LPS). We also attempted to analyze the inflammatory cytokine network among TNFα, IL-1β, IL-8, and IL-1Ra. Understanding the role of cytokines in animal models paves the way to a better understanding of disease in humans.
AB - Studies have suggested the role of cytokines in inflammation, as determined by results obtained in vitro, or with assessments of clinical samples. However, extrapolation of in vitro results to an in vivo situation must be made with caution, and findings obtained from clinical samples tend to lack a causal relation between cytokines and inflammatory responses. Animal models of inflammation can be useful in understanding roles of cytokines at sites of inflammation. We examined the production kinetics and cellular sources of tumor necrosis factor alpha (TNFα), interleukin (IL)-1β, IL-8, and IL-1 receptor antagonist (IL-1Ra), and obtained evidence for the involvement of these cytokines in a rabbit model of arthritis induced by lipopolysaccharide (LPS). We also attempted to analyze the inflammatory cytokine network among TNFα, IL-1β, IL-8, and IL-1Ra. Understanding the role of cytokines in animal models paves the way to a better understanding of disease in humans.
KW - Cytokine
KW - In vivo study
KW - Inflammation
KW - Interleukins
KW - Neutrophils
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U2 - 10.1007/s000110050304
DO - 10.1007/s000110050304
M3 - Article
C2 - 9831316
AN - SCOPUS:0031726586
VL - 47
SP - S137-S144
JO - Inflammation Research
JF - Inflammation Research
SN - 1023-3830
IS - SUPPL. 3
ER -