Sequential expressions of Notch1, Jagged2 and Math1 in molar tooth germ of mouse

Silvia S. Borkosky, Hitoshi Nagatsuka, Yorihisa Orita, Hidetsugu Tsujigiwa, Junko Yoshinobu, Mehmet Gunduz, Andrea P. Rodriguez, Liliana R. Missana, Kazunori Nishizaki, Noriyuki Nagai

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The Notch signaling pathway is an evolutionary conserved mechanism that plays an important role in cell-cell communication and cell fate in a wide range of tissues. The mammalian family of Notch receptors consists of 4 members: Notch1/2/3/4. The Notch ligand family consists of 5 members: Delta1/3/4 and Jagged1/2. Math1 encodes a murine basic helix-loop-helix (bHLH) transcription factor that acts as positive regulator of cell differentiation. Recently, links between Notch and Math1 pathways were demonstrated in various tissues. Expression of Notch1, Jagged2 and Math1 were analyzed in the mouse molar tooth germ during embryonic stage (E) 13 and E15 and during postnatal stage (PN) 1, PN3, PN5, PN10 and PN14 by using in situ hybridization. Positive Notch1 expression was found at the tooth bud during embryonic stages, but its expression was absent from the basal cells in contact with the dental mesenchyme. Jagged2 and Math1 were strongly expressed in differentiated ameloblasts and odontoblasts and Math1 strong expression was even maintained until PN14 stage. Math1 showed the strongest expression. Our results suggest that the Notch1 signaling pathway through Jagged2 could be importantly related to Math1, directing the process of odontogenesis toward cell differentiation.

Original languageEnglish
Pages (from-to)251-257
Number of pages7
JournalBiocell
Volume32
Issue number3
Publication statusPublished - 2008

Fingerprint

Tooth Germ
Cell Differentiation
Tooth
Odontogenesis
Ameloblasts
Notch Receptors
Odontoblasts
Basic Helix-Loop-Helix Transcription Factors
Mesoderm
Cell Communication
In Situ Hybridization
Ligands

Keywords

  • Cell differentiation
  • Molar morphogenesis
  • Notch signaling
  • Odontogenesis

ASJC Scopus subject areas

  • Cell Biology

Cite this

Borkosky, S. S., Nagatsuka, H., Orita, Y., Tsujigiwa, H., Yoshinobu, J., Gunduz, M., ... Nagai, N. (2008). Sequential expressions of Notch1, Jagged2 and Math1 in molar tooth germ of mouse. Biocell, 32(3), 251-257.

Sequential expressions of Notch1, Jagged2 and Math1 in molar tooth germ of mouse. / Borkosky, Silvia S.; Nagatsuka, Hitoshi; Orita, Yorihisa; Tsujigiwa, Hidetsugu; Yoshinobu, Junko; Gunduz, Mehmet; Rodriguez, Andrea P.; Missana, Liliana R.; Nishizaki, Kazunori; Nagai, Noriyuki.

In: Biocell, Vol. 32, No. 3, 2008, p. 251-257.

Research output: Contribution to journalArticle

Borkosky, SS, Nagatsuka, H, Orita, Y, Tsujigiwa, H, Yoshinobu, J, Gunduz, M, Rodriguez, AP, Missana, LR, Nishizaki, K & Nagai, N 2008, 'Sequential expressions of Notch1, Jagged2 and Math1 in molar tooth germ of mouse', Biocell, vol. 32, no. 3, pp. 251-257.
Borkosky SS, Nagatsuka H, Orita Y, Tsujigiwa H, Yoshinobu J, Gunduz M et al. Sequential expressions of Notch1, Jagged2 and Math1 in molar tooth germ of mouse. Biocell. 2008;32(3):251-257.
Borkosky, Silvia S. ; Nagatsuka, Hitoshi ; Orita, Yorihisa ; Tsujigiwa, Hidetsugu ; Yoshinobu, Junko ; Gunduz, Mehmet ; Rodriguez, Andrea P. ; Missana, Liliana R. ; Nishizaki, Kazunori ; Nagai, Noriyuki. / Sequential expressions of Notch1, Jagged2 and Math1 in molar tooth germ of mouse. In: Biocell. 2008 ; Vol. 32, No. 3. pp. 251-257.
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