Abstract
The Notch signaling pathway is an evolutionary conserved mechanism that plays an important role in cell-cell communication and cell fate in a wide range of tissues. The mammalian family of Notch receptors consists of 4 members: Notch1/2/3/4. The Notch ligand family consists of 5 members: Delta1/3/4 and Jagged1/2. Math1 encodes a murine basic helix-loop-helix (bHLH) transcription factor that acts as positive regulator of cell differentiation. Recently, links between Notch and Math1 pathways were demonstrated in various tissues. Expression of Notch1, Jagged2 and Math1 were analyzed in the mouse molar tooth germ during embryonic stage (E) 13 and E15 and during postnatal stage (PN) 1, PN3, PN5, PN10 and PN14 by using in situ hybridization. Positive Notch1 expression was found at the tooth bud during embryonic stages, but its expression was absent from the basal cells in contact with the dental mesenchyme. Jagged2 and Math1 were strongly expressed in differentiated ameloblasts and odontoblasts and Math1 strong expression was even maintained until PN14 stage. Math1 showed the strongest expression. Our results suggest that the Notch1 signaling pathway through Jagged2 could be importantly related to Math1, directing the process of odontogenesis toward cell differentiation.
| Original language | English |
|---|---|
| Pages (from-to) | 251-257 |
| Number of pages | 7 |
| Journal | Biocell |
| Volume | 32 |
| Issue number | 3 |
| Publication status | Published - 2008 |
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Keywords
- Cell differentiation
- Molar morphogenesis
- Notch signaling
- Odontogenesis
ASJC Scopus subject areas
- Cell Biology
Cite this
Sequential expressions of Notch1, Jagged2 and Math1 in molar tooth germ of mouse. / Borkosky, Silvia S.; Nagatsuka, Hitoshi; Orita, Yorihisa; Tsujigiwa, Hidetsugu; Yoshinobu, Junko; Gunduz, Mehmet; Rodriguez, Andrea P.; Missana, Liliana R.; Nishizaki, Kazunori; Nagai, Noriyuki.
In: Biocell, Vol. 32, No. 3, 2008, p. 251-257.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Sequential expressions of Notch1, Jagged2 and Math1 in molar tooth germ of mouse
AU - Borkosky, Silvia S.
AU - Nagatsuka, Hitoshi
AU - Orita, Yorihisa
AU - Tsujigiwa, Hidetsugu
AU - Yoshinobu, Junko
AU - Gunduz, Mehmet
AU - Rodriguez, Andrea P.
AU - Missana, Liliana R.
AU - Nishizaki, Kazunori
AU - Nagai, Noriyuki
PY - 2008
Y1 - 2008
N2 - The Notch signaling pathway is an evolutionary conserved mechanism that plays an important role in cell-cell communication and cell fate in a wide range of tissues. The mammalian family of Notch receptors consists of 4 members: Notch1/2/3/4. The Notch ligand family consists of 5 members: Delta1/3/4 and Jagged1/2. Math1 encodes a murine basic helix-loop-helix (bHLH) transcription factor that acts as positive regulator of cell differentiation. Recently, links between Notch and Math1 pathways were demonstrated in various tissues. Expression of Notch1, Jagged2 and Math1 were analyzed in the mouse molar tooth germ during embryonic stage (E) 13 and E15 and during postnatal stage (PN) 1, PN3, PN5, PN10 and PN14 by using in situ hybridization. Positive Notch1 expression was found at the tooth bud during embryonic stages, but its expression was absent from the basal cells in contact with the dental mesenchyme. Jagged2 and Math1 were strongly expressed in differentiated ameloblasts and odontoblasts and Math1 strong expression was even maintained until PN14 stage. Math1 showed the strongest expression. Our results suggest that the Notch1 signaling pathway through Jagged2 could be importantly related to Math1, directing the process of odontogenesis toward cell differentiation.
AB - The Notch signaling pathway is an evolutionary conserved mechanism that plays an important role in cell-cell communication and cell fate in a wide range of tissues. The mammalian family of Notch receptors consists of 4 members: Notch1/2/3/4. The Notch ligand family consists of 5 members: Delta1/3/4 and Jagged1/2. Math1 encodes a murine basic helix-loop-helix (bHLH) transcription factor that acts as positive regulator of cell differentiation. Recently, links between Notch and Math1 pathways were demonstrated in various tissues. Expression of Notch1, Jagged2 and Math1 were analyzed in the mouse molar tooth germ during embryonic stage (E) 13 and E15 and during postnatal stage (PN) 1, PN3, PN5, PN10 and PN14 by using in situ hybridization. Positive Notch1 expression was found at the tooth bud during embryonic stages, but its expression was absent from the basal cells in contact with the dental mesenchyme. Jagged2 and Math1 were strongly expressed in differentiated ameloblasts and odontoblasts and Math1 strong expression was even maintained until PN14 stage. Math1 showed the strongest expression. Our results suggest that the Notch1 signaling pathway through Jagged2 could be importantly related to Math1, directing the process of odontogenesis toward cell differentiation.
KW - Cell differentiation
KW - Molar morphogenesis
KW - Notch signaling
KW - Odontogenesis
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UR - http://www.scopus.com/inward/citedby.url?scp=58349099425&partnerID=8YFLogxK
M3 - Article
C2 - 19181188
AN - SCOPUS:58349099425
VL - 32
SP - 251
EP - 257
JO - Biocell
JF - Biocell
SN - 0327-9545
IS - 3
ER -