Abstract
Hepatitis C virus (HCV) genomes show sequence diversities among virus isolates. In particular, the putative envelope region encoding gp35 and gp70 shows on extensive sequence diversity in the whole viral genome. We identified two hypervariable regions [HVR1 (27 amino acids) and HVR2 (7 amino acids)] in the N-terminal region of gp70 of the HCV-II genotype. In the HCV-I genotype, extensive diversity of amino acid sequence in HVR1 is also observed in the same region (21 amino acids), but such diversity in HVR2 is not clearly observed like HCV-II genotype. In addition, the alteration of amino acids in HVR1 was also observed in patients with chronic hepatitis. It is suggested mutation in HVR1 is involved in the mechanism of persistent HCV infection.
| Original language | English |
|---|---|
| Pages (from-to) | 318-322 |
| Number of pages | 5 |
| Journal | Nihon rinsho. Japanese journal of clinical medicine |
| Volume | 51 |
| Issue number | 2 |
| Publication status | Published - Feb 1993 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Medicine(all)
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Sequence diversity and variability in the putative envelope proteins including hypervariable regions of hepatitis C virus. / Nakazawa, T.; Hijikata, M.; Kato, Nobuyuki; Shimotohno, K.
In: Nihon rinsho. Japanese journal of clinical medicine, Vol. 51, No. 2, 02.1993, p. 318-322.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Sequence diversity and variability in the putative envelope proteins including hypervariable regions of hepatitis C virus
AU - Nakazawa, T.
AU - Hijikata, M.
AU - Kato, Nobuyuki
AU - Shimotohno, K.
PY - 1993/2
Y1 - 1993/2
N2 - Hepatitis C virus (HCV) genomes show sequence diversities among virus isolates. In particular, the putative envelope region encoding gp35 and gp70 shows on extensive sequence diversity in the whole viral genome. We identified two hypervariable regions [HVR1 (27 amino acids) and HVR2 (7 amino acids)] in the N-terminal region of gp70 of the HCV-II genotype. In the HCV-I genotype, extensive diversity of amino acid sequence in HVR1 is also observed in the same region (21 amino acids), but such diversity in HVR2 is not clearly observed like HCV-II genotype. In addition, the alteration of amino acids in HVR1 was also observed in patients with chronic hepatitis. It is suggested mutation in HVR1 is involved in the mechanism of persistent HCV infection.
AB - Hepatitis C virus (HCV) genomes show sequence diversities among virus isolates. In particular, the putative envelope region encoding gp35 and gp70 shows on extensive sequence diversity in the whole viral genome. We identified two hypervariable regions [HVR1 (27 amino acids) and HVR2 (7 amino acids)] in the N-terminal region of gp70 of the HCV-II genotype. In the HCV-I genotype, extensive diversity of amino acid sequence in HVR1 is also observed in the same region (21 amino acids), but such diversity in HVR2 is not clearly observed like HCV-II genotype. In addition, the alteration of amino acids in HVR1 was also observed in patients with chronic hepatitis. It is suggested mutation in HVR1 is involved in the mechanism of persistent HCV infection.
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M3 - Article
C2 - 8385235
AN - SCOPUS:0027546390
VL - 51
SP - 318
EP - 322
JO - Nippon rinsho. Japanese journal of clinical medicine
JF - Nippon rinsho. Japanese journal of clinical medicine
SN - 0047-1852
IS - 2
ER -