Sensory experience-dependent formation of perineuronal nets and expression of Cat-315 immunoreactive components in the mouse somatosensory cortex

Hiroshi Ueno, Shunsuke Suemitsu, Motoi Okamoto, Yousuke Matsumoto, Takeshi Ishihara

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Perineuronal nets (PNNs) are structures of extracellular matrix molecules surrounding the cell bodies and proximal dendrites of certain neurons. While PNNs are present throughout the mouse cerebral cortex, recent studies have shown that the components differ among cortical sub-regions and layers, suggesting region-specific functions. Parvalbumin-expressing interneurons (PV neurons) may be important regulators of cortical plasticity during the early “critical period” that is sensitive to sensory input. Here we examined the distribution and developmental functions of PNN components associated with PV neurons in the somatosensory cortex during the critical period. Aggrecan, brevican, neurocan, phosphacan, and tenascin-R were identified as PNN components in the mouse somatosensory cortex. High-magnification analysis revealed that some lectin Wisteria floribunda agglutinin (WFA)-reactive molecules did not co-localize with monoclonal antibody Cat-315 recognition molecules around the cell body. During postnatal development, Cat-315-positive (Cat-315+) PNNs appeared later than PNNs binding to the lectin WFA (WFA+ PNNs). These WFA+ PNNs changed from granular-like to reticular-like structures during normal cortical development, while this transition was delayed by sensory deprivation. This study indicates that the formation of reticular-like WFA+ PNNs is dependent on sensory experience in the mouse somatosensory cortex. We suggest that Cat-315+ molecules and WFA expression in PNNs are involved in the early critical period of input-dependent cortical plasticity.

Original languageEnglish
Pages (from-to)161-174
Number of pages14
JournalNeuroscience
Volume355
DOIs
Publication statusPublished - Jul 4 2017

Fingerprint

Somatosensory Cortex
Cats
Parvalbumins
Interneurons
Lectins
Brevican
Neurocan
Class 5 Receptor-Like Protein Tyrosine Phosphatases
Sensory Deprivation
Aggrecans
Reticular Formation
Dendrites
Cerebral Cortex
Extracellular Matrix
wisteria lectin
Monoclonal Antibodies
Neurons
Critical Period (Psychology)

Keywords

  • aggrecan
  • parvalbumin
  • perineuronal nets
  • sensory deprivation
  • somatosensory cortex

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Sensory experience-dependent formation of perineuronal nets and expression of Cat-315 immunoreactive components in the mouse somatosensory cortex. / Ueno, Hiroshi; Suemitsu, Shunsuke; Okamoto, Motoi; Matsumoto, Yousuke; Ishihara, Takeshi.

In: Neuroscience, Vol. 355, 04.07.2017, p. 161-174.

Research output: Contribution to journalArticle

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