Sensitized central controller of ventilation in rats with chronic heart failure contributes to hyperpnea little at rest but more during exercise

Tadayoshi Miyamoto, Masashi Inagaki, Hiroshi Takaki, Atsunori Kamiya, Toru Kawada, Toshiaki Shishido, Masaru Sugimachi, Kenji Sunagawa

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Citations (Scopus)

Abstract

Background: To understand the pathophysiologic basis of exercise hyperpnea in chronic heart failure (CHF), we have developed an experimental method quantitatively characterizing ventilatory regulation system in rats. An equilibrium diagram illustrates the characteristics of two subsytems, i.e., the central controller (arterial CO2 tension [PaCO2] to minute ventilation [VE] relationship) and peripheral plant (VE to PaCO2 relationship). In this study, we compared these between normal and CHF rats at rest. Method: In anesthetized 6 postinfarction CHF rats and 6 normal rats, we induced hypercapnia by changing inspiratory CO2 fraction and measured the steady-state PaCO2 to VE relation. We altered VE by varying the level of artificial ventilation and measured the VE to PaCO2 relation. Results: Central controller gain S was significantly lager in CHF rats, confirming clinical observation. The VE at rest (operating point) in CHF was 24 % larger; central hypersensitivity, however, contributed little (6 %) to this increase. Conclusion: Central hypersensitivity alone would not explain hyperpnea at rest in CHF rats. Considering the right and upward shift of V E to PaCO2 relation, central hypersensitivity contributes more to hyperpnea during exercise. The potential difference between normal and CHF rats in exercise-induced changes in controller and plant should be examined to fully understand the mechanism of exercise hyperpnea and to develop a method to attenuate this.

Original languageEnglish
Title of host publication28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06
Pages4627-4630
Number of pages4
DOIs
Publication statusPublished - Dec 1 2006
Externally publishedYes
Event28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06 - New York, NY, United States
Duration: Aug 30 2006Sep 3 2006

Publication series

NameAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
ISSN (Print)0589-1019

Other

Other28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06
CountryUnited States
CityNew York, NY
Period8/30/069/3/06

    Fingerprint

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

Cite this

Miyamoto, T., Inagaki, M., Takaki, H., Kamiya, A., Kawada, T., Shishido, T., Sugimachi, M., & Sunagawa, K. (2006). Sensitized central controller of ventilation in rats with chronic heart failure contributes to hyperpnea little at rest but more during exercise. In 28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06 (pp. 4627-4630). [4029803] (Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings). https://doi.org/10.1109/IEMBS.2006.260268