Sensitivity and specificity of des-gamma-carboxy prothrombin for diagnosis of patients with hepatocellular carcinomas varies according to tumor size

Shinichiro Nakamura, Kazuhiro Nouso, Kohsaku Sakaguchi, Yoichi M. Ito, Yasuo Ohashi, Yoshiyuki Kobayashi, Nobuyuki Toshikuni, Hironori Tanaka, Yasuhiro Miyake, Eiji Matsumoto, Yasushi Shiratori

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Abstract

OBJECTIVES: Serum levels of des-gamma-carboxy prothrombin (DCP) and alpha-fetoprotein (AFP) are known to be useful tumor markers for the diagnosis of hepatocellular carcinoma (HCC). The aim of this study was to examine the diagnostic efficacy of DCP and AFP in differentiating HCC from chronic liver diseases. METHODS: We examined 1,377 HCC patients and 355 patients with chronic hepatitis or cirrhosis (non-HCC) who visited our institute and affiliated hospitals between June 1997 and September 2003. RESULTS: The median values of DCP and AFP were 60 mAU/mL and 34 ng/mL in HCC patients, respectively, and 18 mAU/mL and 3 ng/mL in non-HCC patients, respectively. The areas under the receiver operating characteristic (ROC) curves of DCP and AFP were 0.812 and 0.887, respectively (p <0.0001). The area under the DCP ROC curve was significantly smaller than that of AFP in tumors less than 3 cm in diameter (p <0.0001). However, the ROC area of DCP was significantly larger than that of AFP in tumors greater than 5 cm in diameter (p <0.0001). CONCLUSIONS: The utility of DCP for the diagnosis of HCC was lower than that of AFP for small tumors, but higher than that of AFP for large tumors.

Original languageEnglish
Pages (from-to)2038-2043
Number of pages6
JournalAmerican Journal of Gastroenterology
Volume101
Issue number9
DOIs
Publication statusPublished - Sep 2006

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alpha-Fetoproteins
Hepatocellular Carcinoma
Sensitivity and Specificity
Neoplasms
ROC Curve
Carcinoma
acarboxyprothrombin
Chronic Hepatitis
Tumor Biomarkers
Liver Diseases
Fibrosis
Chronic Disease
Serum

ASJC Scopus subject areas

  • Gastroenterology

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Sensitivity and specificity of des-gamma-carboxy prothrombin for diagnosis of patients with hepatocellular carcinomas varies according to tumor size. / Nakamura, Shinichiro; Nouso, Kazuhiro; Sakaguchi, Kohsaku; Ito, Yoichi M.; Ohashi, Yasuo; Kobayashi, Yoshiyuki; Toshikuni, Nobuyuki; Tanaka, Hironori; Miyake, Yasuhiro; Matsumoto, Eiji; Shiratori, Yasushi.

In: American Journal of Gastroenterology, Vol. 101, No. 9, 09.2006, p. 2038-2043.

Research output: Contribution to journalArticle

Nakamura, S, Nouso, K, Sakaguchi, K, Ito, YM, Ohashi, Y, Kobayashi, Y, Toshikuni, N, Tanaka, H, Miyake, Y, Matsumoto, E & Shiratori, Y 2006, 'Sensitivity and specificity of des-gamma-carboxy prothrombin for diagnosis of patients with hepatocellular carcinomas varies according to tumor size', American Journal of Gastroenterology, vol. 101, no. 9, pp. 2038-2043. https://doi.org/10.1111/j.1572-0241.2006.00681.x
Nakamura, Shinichiro ; Nouso, Kazuhiro ; Sakaguchi, Kohsaku ; Ito, Yoichi M. ; Ohashi, Yasuo ; Kobayashi, Yoshiyuki ; Toshikuni, Nobuyuki ; Tanaka, Hironori ; Miyake, Yasuhiro ; Matsumoto, Eiji ; Shiratori, Yasushi. / Sensitivity and specificity of des-gamma-carboxy prothrombin for diagnosis of patients with hepatocellular carcinomas varies according to tumor size. In: American Journal of Gastroenterology. 2006 ; Vol. 101, No. 9. pp. 2038-2043.
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abstract = "OBJECTIVES: Serum levels of des-gamma-carboxy prothrombin (DCP) and alpha-fetoprotein (AFP) are known to be useful tumor markers for the diagnosis of hepatocellular carcinoma (HCC). The aim of this study was to examine the diagnostic efficacy of DCP and AFP in differentiating HCC from chronic liver diseases. METHODS: We examined 1,377 HCC patients and 355 patients with chronic hepatitis or cirrhosis (non-HCC) who visited our institute and affiliated hospitals between June 1997 and September 2003. RESULTS: The median values of DCP and AFP were 60 mAU/mL and 34 ng/mL in HCC patients, respectively, and 18 mAU/mL and 3 ng/mL in non-HCC patients, respectively. The areas under the receiver operating characteristic (ROC) curves of DCP and AFP were 0.812 and 0.887, respectively (p <0.0001). The area under the DCP ROC curve was significantly smaller than that of AFP in tumors less than 3 cm in diameter (p <0.0001). However, the ROC area of DCP was significantly larger than that of AFP in tumors greater than 5 cm in diameter (p <0.0001). CONCLUSIONS: The utility of DCP for the diagnosis of HCC was lower than that of AFP for small tumors, but higher than that of AFP for large tumors.",
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AU - Nouso, Kazuhiro

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AU - Ito, Yoichi M.

AU - Ohashi, Yasuo

AU - Kobayashi, Yoshiyuki

AU - Toshikuni, Nobuyuki

AU - Tanaka, Hironori

AU - Miyake, Yasuhiro

AU - Matsumoto, Eiji

AU - Shiratori, Yasushi

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