Selegilin exerts antidepressant-like effects during the forced swim test in adrenocorticotropic hormone-treated rats

Yoshihisa Kitamura, Kouhei Kitagawa, Shizue Kimoto, Hidenori Sagara, Kazuhiko Shibata, Hiromu Kawasaki, Toshiaki Sendo, Yutaka Gomita

Research output: Contribution to journalArticle

8 Citations (Scopus)


In the present study, we investigated the effect of adrenocorticotropic hormone (ACTH) on the immobilization of rats in the forced swim test after the administration of selegiline, a selective and irreversible monoamine oxidase (MAO)-B inhibitor. Single and repeated administration of selegiline significantly decreased the duration of immobility in normal rats. When selegiline was administered for 15 days, we observed a significant decrease in immobility in rats treated with ACTH for 14 days. The immobility-decreasing effect of selegiline was blocked by nafadotride, a selective dopamine D 3-receptor antagonist in normal and ACTH-treated rats. Selegiline may be useful in an animal model of depressive conditions resistant to tricyclic antidepressant treatment via the dopamine D3 receptor.

Original languageEnglish
Pages (from-to)639-644
Number of pages6
JournalJournal of Pharmacological Sciences
Issue number4
Publication statusPublished - Apr 24 2008



  • Dopamine D receptor
  • Forced swim test
  • Monoamine oxidase-B
  • Selegiline
  • Treatment-resistance depression

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

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