Selegilin exerts antidepressant-like effects during the forced swim test in adrenocorticotropic hormone-treated rats

Yoshihisa Kitamura; Kouhei Kitagawa; Shizue Kimoto; Hidenori Sagara; Kazuhiko Shibata; Hiromu Kawasaki; Toshiaki Sendo; Yutaka Gomita

doi:10.1254/jphs.FP0072150

Selegilin exerts antidepressant-like effects during the forced swim test in adrenocorticotropic hormone-treated rats

Yoshihisa Kitamura, Kouhei Kitagawa, Shizue Kimoto, Hidenori Sagara, Kazuhiko Shibata, Hiromu Kawasaki, Toshiaki Sendo, Yutaka Gomita

University Hospital

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

In the present study, we investigated the effect of adrenocorticotropic hormone (ACTH) on the immobilization of rats in the forced swim test after the administration of selegiline, a selective and irreversible monoamine oxidase (MAO)-B inhibitor. Single and repeated administration of selegiline significantly decreased the duration of immobility in normal rats. When selegiline was administered for 15 days, we observed a significant decrease in immobility in rats treated with ACTH for 14 days. The immobility-decreasing effect of selegiline was blocked by nafadotride, a selective dopamine D ₃-receptor antagonist in normal and ACTH-treated rats. Selegiline may be useful in an animal model of depressive conditions resistant to tricyclic antidepressant treatment via the dopamine D₃ receptor.

Original language	English
Pages (from-to)	639-644
Number of pages	6
Journal	Journal of Pharmacological Sciences
Volume	106
Issue number	4
DOIs	https://doi.org/10.1254/jphs.FP0072150
Publication status	Published - 2008

Keywords

Dopamine D receptor
Forced swim test
Monoamine oxidase-B
Selegiline
Treatment-resistance depression

ASJC Scopus subject areas

Molecular Medicine
Pharmacology

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10.1254/jphs.FP0072150

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title = "Selegilin exerts antidepressant-like effects during the forced swim test in adrenocorticotropic hormone-treated rats",

abstract = "In the present study, we investigated the effect of adrenocorticotropic hormone (ACTH) on the immobilization of rats in the forced swim test after the administration of selegiline, a selective and irreversible monoamine oxidase (MAO)-B inhibitor. Single and repeated administration of selegiline significantly decreased the duration of immobility in normal rats. When selegiline was administered for 15 days, we observed a significant decrease in immobility in rats treated with ACTH for 14 days. The immobility-decreasing effect of selegiline was blocked by nafadotride, a selective dopamine D 3-receptor antagonist in normal and ACTH-treated rats. Selegiline may be useful in an animal model of depressive conditions resistant to tricyclic antidepressant treatment via the dopamine D3 receptor.",

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AU - Kitamura, Yoshihisa

AU - Kitagawa, Kouhei

AU - Kimoto, Shizue

AU - Sagara, Hidenori

AU - Shibata, Kazuhiko

AU - Kawasaki, Hiromu

AU - Sendo, Toshiaki

AU - Gomita, Yutaka

PY - 2008

Y1 - 2008

N2 - In the present study, we investigated the effect of adrenocorticotropic hormone (ACTH) on the immobilization of rats in the forced swim test after the administration of selegiline, a selective and irreversible monoamine oxidase (MAO)-B inhibitor. Single and repeated administration of selegiline significantly decreased the duration of immobility in normal rats. When selegiline was administered for 15 days, we observed a significant decrease in immobility in rats treated with ACTH for 14 days. The immobility-decreasing effect of selegiline was blocked by nafadotride, a selective dopamine D 3-receptor antagonist in normal and ACTH-treated rats. Selegiline may be useful in an animal model of depressive conditions resistant to tricyclic antidepressant treatment via the dopamine D3 receptor.

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KW - Dopamine D receptor

KW - Forced swim test

KW - Monoamine oxidase-B

KW - Selegiline

KW - Treatment-resistance depression

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ER -

Selegilin exerts antidepressant-like effects during the forced swim test in adrenocorticotropic hormone-treated rats

Abstract

Keywords

ASJC Scopus subject areas

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