Selectively substituted thiophenes and indoles by a tandem palladium-catalyzed multicomponent reaction

Koichi Mitsudo, Praew Thansandote, Thorsten Wilhelm, Brian Mariampillai, Mark Lautens

Research output: Contribution to journalArticlepeer-review

67 Citations (Scopus)

Abstract

A variety of di- and trisubstituted thiophenes were synthesized by a one-pot palladium-catalyzed ortho-alkylation sequence terminated by either Heck or C-H coupling. Initial results toward the functionalization of indoles are also presented.

Original languageEnglish
Pages (from-to)3939-3942
Number of pages4
JournalOrganic Letters
Volume8
Issue number18
DOIs
Publication statusPublished - Aug 31 2006
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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