Selective recruitment of CXCR3+ and CCR5+ CD4 + T cells into synovial tissue in patients with rheumatoid arthritis

Mika Norii, Masahiro Yamamura, Mitsuhiro Iwahashi, Akiko Ueno, Jiro Yamana, Hirofumi Makino

Research output: Contribution to journal › Article

19 Citations (Scopus)

Abstract

The inflamed synovial tissue (ST) of rheumatoid arthritis (RA) is characterized by the selective accumulation of interferon γ-producing Th1-type CD4+ T cells. In this study, we investigated whether the predominance of Th1-type CD4+ cells in the ST lesion is mediated by their selective recruitment through Th1 cell-associated chemokine receptors CXCR3 and CCR5. The lymphocyte aggregates in the ST of RA contained a large number of CD4+ T cells, which mostly expressed both CXCR3 and CCR5, but not CCR4. In contrast, the frequencies of CD4+ and CD8 + T cells expressing CXCR3 and CCR5 in the blood were significantly decreased in RA patients, compared with healthy controls (HC), although there was no difference in the frequencies of CCR4-expressing CD4+ and CD8+ T cells between RA and HC. CXCR3, CCR5, and CCR4 expression in blood CD4+ T cells and CXCR3 expression in CD8+ T cells were increased after interleukin-15 (IL-15) stimulation. Therefore, the distribution of Th1-type CD4+ T cells into the ST from the blood in RA may be associated with the local expression of chemokines, both CXCR3 and CCR5 ligands, and IL-15 may play a role in enhancing these chemokine receptors on CD4+ T cell infiltrates. Copyright

Original languageEnglish
Pages (from-to)149-157
Number of pages9
JournalActa Medica Okayama
Volume60
Issue number3
Publication statusPublished - Sep 4 2006

Fingerprint

T-cells
Rheumatoid Arthritis
Tissue
T-Lymphocytes
Interleukin-15
Th1 Cells
Blood
Chemokine Receptors
Lymphocytes
Chemokines
Interferons
Ligands

Keywords

  • CCR5
  • Cd4 T cells
  • CXCR3
  • Interleukin-15
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Selective recruitment of CXCR3+ and CCR5+ CD4 + T cells into synovial tissue in patients with rheumatoid arthritis. / Norii, Mika; Yamamura, Masahiro; Iwahashi, Mitsuhiro; Ueno, Akiko; Yamana, Jiro; Makino, Hirofumi.

In: Acta Medica Okayama, Vol. 60, No. 3, 04.09.2006, p. 149-157.

Research output: Contribution to journal › Article

Norii, M, Yamamura, M, Iwahashi, M, Ueno, A, Yamana, J & Makino, H 2006, 'Selective recruitment of CXCR3+ and CCR5+ CD4 + T cells into synovial tissue in patients with rheumatoid arthritis', Acta Medica Okayama, vol. 60, no. 3, pp. 149-157.
Norii M, Yamamura M, Iwahashi M, Ueno A, Yamana J, Makino H. Selective recruitment of CXCR3+ and CCR5+ CD4 + T cells into synovial tissue in patients with rheumatoid arthritis. Acta Medica Okayama. 2006 Sep 4;60(3):149-157.
Norii, Mika ; Yamamura, Masahiro ; Iwahashi, Mitsuhiro ; Ueno, Akiko ; Yamana, Jiro ; Makino, Hirofumi. / Selective recruitment of CXCR3+ and CCR5+ CD4 + T cells into synovial tissue in patients with rheumatoid arthritis. In: Acta Medica Okayama. 2006 ; Vol. 60, No. 3. pp. 149-157.
@article{215399599f5b406ba4d290b83dc10137,
title = "Selective recruitment of CXCR3+ and CCR5+ CD4 + T cells into synovial tissue in patients with rheumatoid arthritis",
abstract = "The inflamed synovial tissue (ST) of rheumatoid arthritis (RA) is characterized by the selective accumulation of interferon γ-producing Th1-type CD4+ T cells. In this study, we investigated whether the predominance of Th1-type CD4+ cells in the ST lesion is mediated by their selective recruitment through Th1 cell-associated chemokine receptors CXCR3 and CCR5. The lymphocyte aggregates in the ST of RA contained a large number of CD4+ T cells, which mostly expressed both CXCR3 and CCR5, but not CCR4. In contrast, the frequencies of CD4+ and CD8 + T cells expressing CXCR3 and CCR5 in the blood were significantly decreased in RA patients, compared with healthy controls (HC), although there was no difference in the frequencies of CCR4-expressing CD4+ and CD8+ T cells between RA and HC. CXCR3, CCR5, and CCR4 expression in blood CD4+ T cells and CXCR3 expression in CD8+ T cells were increased after interleukin-15 (IL-15) stimulation. Therefore, the distribution of Th1-type CD4+ T cells into the ST from the blood in RA may be associated with the local expression of chemokines, both CXCR3 and CCR5 ligands, and IL-15 may play a role in enhancing these chemokine receptors on CD4+ T cell infiltrates. Copyright",
keywords = "CCR5, Cd4 T cells, CXCR3, Interleukin-15, Rheumatoid arthritis",
author = "Mika Norii and Masahiro Yamamura and Mitsuhiro Iwahashi and Akiko Ueno and Jiro Yamana and Hirofumi Makino",
year = "2006",
month = "9",
day = "4",
language = "English",
volume = "60",
pages = "149--157",
journal = "Acta Medica Okayama",
issn = "0386-300X",
publisher = "Okayama University",
number = "3",

}

TY - JOUR

T1 - Selective recruitment of CXCR3+ and CCR5+ CD4 + T cells into synovial tissue in patients with rheumatoid arthritis

AU - Norii, Mika

AU - Yamamura, Masahiro

AU - Iwahashi, Mitsuhiro

AU - Ueno, Akiko

AU - Yamana, Jiro

AU - Makino, Hirofumi

PY - 2006/9/4

Y1 - 2006/9/4

N2 - The inflamed synovial tissue (ST) of rheumatoid arthritis (RA) is characterized by the selective accumulation of interferon γ-producing Th1-type CD4+ T cells. In this study, we investigated whether the predominance of Th1-type CD4+ cells in the ST lesion is mediated by their selective recruitment through Th1 cell-associated chemokine receptors CXCR3 and CCR5. The lymphocyte aggregates in the ST of RA contained a large number of CD4+ T cells, which mostly expressed both CXCR3 and CCR5, but not CCR4. In contrast, the frequencies of CD4+ and CD8 + T cells expressing CXCR3 and CCR5 in the blood were significantly decreased in RA patients, compared with healthy controls (HC), although there was no difference in the frequencies of CCR4-expressing CD4+ and CD8+ T cells between RA and HC. CXCR3, CCR5, and CCR4 expression in blood CD4+ T cells and CXCR3 expression in CD8+ T cells were increased after interleukin-15 (IL-15) stimulation. Therefore, the distribution of Th1-type CD4+ T cells into the ST from the blood in RA may be associated with the local expression of chemokines, both CXCR3 and CCR5 ligands, and IL-15 may play a role in enhancing these chemokine receptors on CD4+ T cell infiltrates. Copyright

AB - The inflamed synovial tissue (ST) of rheumatoid arthritis (RA) is characterized by the selective accumulation of interferon γ-producing Th1-type CD4+ T cells. In this study, we investigated whether the predominance of Th1-type CD4+ cells in the ST lesion is mediated by their selective recruitment through Th1 cell-associated chemokine receptors CXCR3 and CCR5. The lymphocyte aggregates in the ST of RA contained a large number of CD4+ T cells, which mostly expressed both CXCR3 and CCR5, but not CCR4. In contrast, the frequencies of CD4+ and CD8 + T cells expressing CXCR3 and CCR5 in the blood were significantly decreased in RA patients, compared with healthy controls (HC), although there was no difference in the frequencies of CCR4-expressing CD4+ and CD8+ T cells between RA and HC. CXCR3, CCR5, and CCR4 expression in blood CD4+ T cells and CXCR3 expression in CD8+ T cells were increased after interleukin-15 (IL-15) stimulation. Therefore, the distribution of Th1-type CD4+ T cells into the ST from the blood in RA may be associated with the local expression of chemokines, both CXCR3 and CCR5 ligands, and IL-15 may play a role in enhancing these chemokine receptors on CD4+ T cell infiltrates. Copyright

KW - CCR5

KW - Cd4 T cells

KW - CXCR3

KW - Interleukin-15

KW - Rheumatoid arthritis

UR - http://www.scopus.com/inward/record.url?scp=33748060859&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33748060859&partnerID=8YFLogxK

M3 - Article

C2 - 16838043

AN - SCOPUS:33748060859

VL - 60

SP - 149

EP - 157

JO - Acta Medica Okayama

JF - Acta Medica Okayama

SN - 0386-300X

IS - 3

ER -

Access to Document