Selective recruitment of CXCR3+ and CCR5+ CD4 + T cells into synovial tissue in patients with rheumatoid arthritis

Mika Norii, Masahiro Yamamura, Mitsuhiro Iwahashi, Akiko Ueno, Jiro Yamana, Hirofumi Makino

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The inflamed synovial tissue (ST) of rheumatoid arthritis (RA) is characterized by the selective accumulation of interferon γ-producing Th1-type CD4+ T cells. In this study, we investigated whether the predominance of Th1-type CD4+ cells in the ST lesion is mediated by their selective recruitment through Th1 cell-associated chemokine receptors CXCR3 and CCR5. The lymphocyte aggregates in the ST of RA contained a large number of CD4+ T cells, which mostly expressed both CXCR3 and CCR5, but not CCR4. In contrast, the frequencies of CD4+ and CD8 + T cells expressing CXCR3 and CCR5 in the blood were significantly decreased in RA patients, compared with healthy controls (HC), although there was no difference in the frequencies of CCR4-expressing CD4+ and CD8+ T cells between RA and HC. CXCR3, CCR5, and CCR4 expression in blood CD4+ T cells and CXCR3 expression in CD8+ T cells were increased after interleukin-15 (IL-15) stimulation. Therefore, the distribution of Th1-type CD4+ T cells into the ST from the blood in RA may be associated with the local expression of chemokines, both CXCR3 and CCR5 ligands, and IL-15 may play a role in enhancing these chemokine receptors on CD4+ T cell infiltrates. Copyright

Original languageEnglish
Pages (from-to)149-157
Number of pages9
JournalActa Medica Okayama
Volume60
Issue number3
Publication statusPublished - Sep 4 2006

Fingerprint

T-cells
Rheumatoid Arthritis
Tissue
T-Lymphocytes
Interleukin-15
Th1 Cells
Blood
Chemokine Receptors
Lymphocytes
Chemokines
Interferons
Ligands

Keywords

  • CCR5
  • Cd4 T cells
  • CXCR3
  • Interleukin-15
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Selective recruitment of CXCR3+ and CCR5+ CD4 + T cells into synovial tissue in patients with rheumatoid arthritis. / Norii, Mika; Yamamura, Masahiro; Iwahashi, Mitsuhiro; Ueno, Akiko; Yamana, Jiro; Makino, Hirofumi.

In: Acta Medica Okayama, Vol. 60, No. 3, 04.09.2006, p. 149-157.

Research output: Contribution to journalArticle

Norii, Mika ; Yamamura, Masahiro ; Iwahashi, Mitsuhiro ; Ueno, Akiko ; Yamana, Jiro ; Makino, Hirofumi. / Selective recruitment of CXCR3+ and CCR5+ CD4 + T cells into synovial tissue in patients with rheumatoid arthritis. In: Acta Medica Okayama. 2006 ; Vol. 60, No. 3. pp. 149-157.
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abstract = "The inflamed synovial tissue (ST) of rheumatoid arthritis (RA) is characterized by the selective accumulation of interferon γ-producing Th1-type CD4+ T cells. In this study, we investigated whether the predominance of Th1-type CD4+ cells in the ST lesion is mediated by their selective recruitment through Th1 cell-associated chemokine receptors CXCR3 and CCR5. The lymphocyte aggregates in the ST of RA contained a large number of CD4+ T cells, which mostly expressed both CXCR3 and CCR5, but not CCR4. In contrast, the frequencies of CD4+ and CD8 + T cells expressing CXCR3 and CCR5 in the blood were significantly decreased in RA patients, compared with healthy controls (HC), although there was no difference in the frequencies of CCR4-expressing CD4+ and CD8+ T cells between RA and HC. CXCR3, CCR5, and CCR4 expression in blood CD4+ T cells and CXCR3 expression in CD8+ T cells were increased after interleukin-15 (IL-15) stimulation. Therefore, the distribution of Th1-type CD4+ T cells into the ST from the blood in RA may be associated with the local expression of chemokines, both CXCR3 and CCR5 ligands, and IL-15 may play a role in enhancing these chemokine receptors on CD4+ T cell infiltrates. Copyright",
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