Abstract
The inflamed synovial tissue (ST) of rheumatoid arthritis (RA) is characterized by the selective accumulation of interferon γ-producing Th1-type CD4+ T cells. In this study, we investigated whether the predominance of Th1-type CD4+ cells in the ST lesion is mediated by their selective recruitment through Th1 cell-associated chemokine receptors CXCR3 and CCR5. The lymphocyte aggregates in the ST of RA contained a large number of CD4+ T cells, which mostly expressed both CXCR3 and CCR5, but not CCR4. In contrast, the frequencies of CD4+ and CD8 + T cells expressing CXCR3 and CCR5 in the blood were significantly decreased in RA patients, compared with healthy controls (HC), although there was no difference in the frequencies of CCR4-expressing CD4+ and CD8+ T cells between RA and HC. CXCR3, CCR5, and CCR4 expression in blood CD4+ T cells and CXCR3 expression in CD8+ T cells were increased after interleukin-15 (IL-15) stimulation. Therefore, the distribution of Th1-type CD4+ T cells into the ST from the blood in RA may be associated with the local expression of chemokines, both CXCR3 and CCR5 ligands, and IL-15 may play a role in enhancing these chemokine receptors on CD4+ T cell infiltrates. Copyright
Original language | English |
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Pages (from-to) | 149-157 |
Number of pages | 9 |
Journal | Acta Medica Okayama |
Volume | 60 |
Issue number | 3 |
Publication status | Published - Sep 4 2006 |
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Keywords
- CCR5
- Cd4 T cells
- CXCR3
- Interleukin-15
- Rheumatoid arthritis
ASJC Scopus subject areas
- Medicine(all)
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Selective recruitment of CXCR3+ and CCR5+ CD4 + T cells into synovial tissue in patients with rheumatoid arthritis. / Norii, Mika; Yamamura, Masahiro; Iwahashi, Mitsuhiro; Ueno, Akiko; Yamana, Jiro; Makino, Hirofumi.
In: Acta Medica Okayama, Vol. 60, No. 3, 04.09.2006, p. 149-157.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Selective recruitment of CXCR3+ and CCR5+ CD4 + T cells into synovial tissue in patients with rheumatoid arthritis
AU - Norii, Mika
AU - Yamamura, Masahiro
AU - Iwahashi, Mitsuhiro
AU - Ueno, Akiko
AU - Yamana, Jiro
AU - Makino, Hirofumi
PY - 2006/9/4
Y1 - 2006/9/4
N2 - The inflamed synovial tissue (ST) of rheumatoid arthritis (RA) is characterized by the selective accumulation of interferon γ-producing Th1-type CD4+ T cells. In this study, we investigated whether the predominance of Th1-type CD4+ cells in the ST lesion is mediated by their selective recruitment through Th1 cell-associated chemokine receptors CXCR3 and CCR5. The lymphocyte aggregates in the ST of RA contained a large number of CD4+ T cells, which mostly expressed both CXCR3 and CCR5, but not CCR4. In contrast, the frequencies of CD4+ and CD8 + T cells expressing CXCR3 and CCR5 in the blood were significantly decreased in RA patients, compared with healthy controls (HC), although there was no difference in the frequencies of CCR4-expressing CD4+ and CD8+ T cells between RA and HC. CXCR3, CCR5, and CCR4 expression in blood CD4+ T cells and CXCR3 expression in CD8+ T cells were increased after interleukin-15 (IL-15) stimulation. Therefore, the distribution of Th1-type CD4+ T cells into the ST from the blood in RA may be associated with the local expression of chemokines, both CXCR3 and CCR5 ligands, and IL-15 may play a role in enhancing these chemokine receptors on CD4+ T cell infiltrates. Copyright
AB - The inflamed synovial tissue (ST) of rheumatoid arthritis (RA) is characterized by the selective accumulation of interferon γ-producing Th1-type CD4+ T cells. In this study, we investigated whether the predominance of Th1-type CD4+ cells in the ST lesion is mediated by their selective recruitment through Th1 cell-associated chemokine receptors CXCR3 and CCR5. The lymphocyte aggregates in the ST of RA contained a large number of CD4+ T cells, which mostly expressed both CXCR3 and CCR5, but not CCR4. In contrast, the frequencies of CD4+ and CD8 + T cells expressing CXCR3 and CCR5 in the blood were significantly decreased in RA patients, compared with healthy controls (HC), although there was no difference in the frequencies of CCR4-expressing CD4+ and CD8+ T cells between RA and HC. CXCR3, CCR5, and CCR4 expression in blood CD4+ T cells and CXCR3 expression in CD8+ T cells were increased after interleukin-15 (IL-15) stimulation. Therefore, the distribution of Th1-type CD4+ T cells into the ST from the blood in RA may be associated with the local expression of chemokines, both CXCR3 and CCR5 ligands, and IL-15 may play a role in enhancing these chemokine receptors on CD4+ T cell infiltrates. Copyright
KW - CCR5
KW - Cd4 T cells
KW - CXCR3
KW - Interleukin-15
KW - Rheumatoid arthritis
UR - http://www.scopus.com/inward/record.url?scp=33748060859&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33748060859&partnerID=8YFLogxK
M3 - Article
C2 - 16838043
AN - SCOPUS:33748060859
VL - 60
SP - 149
EP - 157
JO - Acta Medica Okayama
JF - Acta Medica Okayama
SN - 0386-300X
IS - 3
ER -