Selective protein adsorption property and structure of "nano- crystalline hydroxy-carbonate apatite

Satoshi Hayakawa, K. Ohnishi, K. Tsuru, A. Osaka, E. Fujii, K. Kawabata, F. Babonneau, C. Bonhomme

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The selective protein adsorption property and the local structure around carbonate ions of nanocrystalline hydroxy-carbonate apatite were examined in this study. Considerable change in the selectivity in the adsorption of BSA and β2-MG was observed due to the incorporation of the carbonate ions in hydroxyapatite lattice. Since the protein adsorption property seems to be related to the surface charge density of hydroxyapatite due to the carbonation, the chemical states of the incorporated carbonate ions were examined by the 31C CP-MAS NMR spectroscopy. At least four peaks assignable to carbonate ions in A-site(OH-) and B-site(PO 43-) were observed in 13C CP-MAS NMR spectrum. Thus, we must take into consideration that the surface charge distribution and the decrement of polar groups such as OH- groups due to the distribution of carbonate ions in both A- and B-sites of the hydroxyapatite lattice are particularly favorable for β2-MG adsorption rather than for BSA adsorption.

Original languageEnglish
Pages (from-to)503-506
Number of pages4
JournalKey Engineering Materials
Volume309-311 I
Publication statusPublished - 2006

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Carbonates
Apatite
Ions
Crystalline materials
Proteins
Adsorption
Durapatite
Hydroxyapatite
Surface charge
Carbonation
Charge distribution
Charge density
Nuclear magnetic resonance spectroscopy
Nuclear magnetic resonance
carboapatite
hydroxide ion

Keywords

  • Carbonate
  • Hydroxyapatite
  • Nanocrystal
  • NMR
  • Protein Adsorption
  • Structure

ASJC Scopus subject areas

  • Ceramics and Composites
  • Chemical Engineering (miscellaneous)

Cite this

Hayakawa, S., Ohnishi, K., Tsuru, K., Osaka, A., Fujii, E., Kawabata, K., ... Bonhomme, C. (2006). Selective protein adsorption property and structure of "nano- crystalline hydroxy-carbonate apatite. Key Engineering Materials, 309-311 I, 503-506.

Selective protein adsorption property and structure of "nano- crystalline hydroxy-carbonate apatite. / Hayakawa, Satoshi; Ohnishi, K.; Tsuru, K.; Osaka, A.; Fujii, E.; Kawabata, K.; Babonneau, F.; Bonhomme, C.

In: Key Engineering Materials, Vol. 309-311 I, 2006, p. 503-506.

Research output: Contribution to journalArticle

Hayakawa, S, Ohnishi, K, Tsuru, K, Osaka, A, Fujii, E, Kawabata, K, Babonneau, F & Bonhomme, C 2006, 'Selective protein adsorption property and structure of "nano- crystalline hydroxy-carbonate apatite', Key Engineering Materials, vol. 309-311 I, pp. 503-506.
Hayakawa, Satoshi ; Ohnishi, K. ; Tsuru, K. ; Osaka, A. ; Fujii, E. ; Kawabata, K. ; Babonneau, F. ; Bonhomme, C. / Selective protein adsorption property and structure of "nano- crystalline hydroxy-carbonate apatite. In: Key Engineering Materials. 2006 ; Vol. 309-311 I. pp. 503-506.
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