Abstract
Nano-crystalline Zn-containing hydroxyapatite (ZnHAp) was prepared by the wet-chemical method and the selective adsorption of essential proteins was examined, taking bovine serum albumin (BSA) and pathogenic protein such as β2-microglobulin (β2-MG) as model proteins. Transmission electron microscopy observation and X-ray diffraction analysis indicated that the increase of Zn content led to smaller crystallites and their specific surface area of ZnHAps increased with increasing Zn content, accordingly. Furthermore, the amounts of BSA adsorption on ZnHAp particles decreased with increasing Zn content in spite of the increase in the specific surface area. It is thus concluded that nano-crystalline ZnHAps had a highly selective adsorption property with regard to β2-MG.
| Original language | English |
|---|---|
| Pages (from-to) | 69-74 |
| Number of pages | 6 |
| Journal | Acta Biomaterialia |
| Volume | 2 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 2006 |
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Keywords
- Adsorption
- Albumin
- Calcium phosphate
- Hydroxyapatite
- Zinc
ASJC Scopus subject areas
- Biomaterials
- Biomedical Engineering
- Biotechnology
- Biochemistry
- Molecular Biology
Cite this
Selective protein adsorption property and characterization of nano-crystalline zinc-containing hydroxyapatite. / Fujii, Eiji; Ohkubo, Mizuki; Tsuru, Kanji; Hayakawa, Satoshi; Osaka, Akiyoshi; Kawabata, Koji; Bonhomme, Christian; Babonneau, Florence.
In: Acta Biomaterialia, Vol. 2, No. 1, 01.2006, p. 69-74.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Selective protein adsorption property and characterization of nano-crystalline zinc-containing hydroxyapatite
AU - Fujii, Eiji
AU - Ohkubo, Mizuki
AU - Tsuru, Kanji
AU - Hayakawa, Satoshi
AU - Osaka, Akiyoshi
AU - Kawabata, Koji
AU - Bonhomme, Christian
AU - Babonneau, Florence
PY - 2006/1
Y1 - 2006/1
N2 - Nano-crystalline Zn-containing hydroxyapatite (ZnHAp) was prepared by the wet-chemical method and the selective adsorption of essential proteins was examined, taking bovine serum albumin (BSA) and pathogenic protein such as β2-microglobulin (β2-MG) as model proteins. Transmission electron microscopy observation and X-ray diffraction analysis indicated that the increase of Zn content led to smaller crystallites and their specific surface area of ZnHAps increased with increasing Zn content, accordingly. Furthermore, the amounts of BSA adsorption on ZnHAp particles decreased with increasing Zn content in spite of the increase in the specific surface area. It is thus concluded that nano-crystalline ZnHAps had a highly selective adsorption property with regard to β2-MG.
AB - Nano-crystalline Zn-containing hydroxyapatite (ZnHAp) was prepared by the wet-chemical method and the selective adsorption of essential proteins was examined, taking bovine serum albumin (BSA) and pathogenic protein such as β2-microglobulin (β2-MG) as model proteins. Transmission electron microscopy observation and X-ray diffraction analysis indicated that the increase of Zn content led to smaller crystallites and their specific surface area of ZnHAps increased with increasing Zn content, accordingly. Furthermore, the amounts of BSA adsorption on ZnHAp particles decreased with increasing Zn content in spite of the increase in the specific surface area. It is thus concluded that nano-crystalline ZnHAps had a highly selective adsorption property with regard to β2-MG.
KW - Adsorption
KW - Albumin
KW - Calcium phosphate
KW - Hydroxyapatite
KW - Zinc
UR - http://www.scopus.com/inward/record.url?scp=33644810382&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33644810382&partnerID=8YFLogxK
U2 - 10.1016/j.actbio.2005.09.002
DO - 10.1016/j.actbio.2005.09.002
M3 - Article
C2 - 16701860
AN - SCOPUS:33644810382
VL - 2
SP - 69
EP - 74
JO - Acta Biomaterialia
JF - Acta Biomaterialia
SN - 1742-7061
IS - 1
ER -