Selective protein adsorption property and characterization of nano-crystalline zinc-containing hydroxyapatite

Eiji Fujii, Mizuki Ohkubo, Kanji Tsuru, Satoshi Hayakawa, Akiyoshi Osaka, Koji Kawabata, Christian Bonhomme, Florence Babonneau

Research output: Contribution to journalArticle

138 Citations (Scopus)

Abstract

Nano-crystalline Zn-containing hydroxyapatite (ZnHAp) was prepared by the wet-chemical method and the selective adsorption of essential proteins was examined, taking bovine serum albumin (BSA) and pathogenic protein such as β2-microglobulin (β2-MG) as model proteins. Transmission electron microscopy observation and X-ray diffraction analysis indicated that the increase of Zn content led to smaller crystallites and their specific surface area of ZnHAps increased with increasing Zn content, accordingly. Furthermore, the amounts of BSA adsorption on ZnHAp particles decreased with increasing Zn content in spite of the increase in the specific surface area. It is thus concluded that nano-crystalline ZnHAps had a highly selective adsorption property with regard to β2-MG.

Original languageEnglish
Pages (from-to)69-74
Number of pages6
JournalActa Biomaterialia
Volume2
Issue number1
DOIs
Publication statusPublished - Jan 1 2006

Keywords

  • Adsorption
  • Albumin
  • Calcium phosphate
  • Hydroxyapatite
  • Zinc

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • Biochemistry
  • Biomedical Engineering
  • Molecular Biology

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