Selective induction of Kunitz-type protease inhibitor domain-containing amyloid precursor protein mRNA after persistent focal ischemia in rat cerebral cortex

Koji Abe, Rudolph E. Tanzi, Kyuya Kogure

Research output: Contribution to journalArticle

192 Citations (Scopus)

Abstract

An induction of amyloid precursor protein (APP) mRNA was examined in a middle cerebral artery occlusion model of rats using Northern blot analyses. The level of tubulin mRNA was measured as an internal standard. With persistent focal ischemia, APP mRNA species which contain a Kunitz-type protease inhibitor (KPI) domain were induced in the rat cerebral cortex from 1 to 21 days after the insult with a maximum at 4 days, while total amounts of APP mRNA did not change. No change was observed in the level of tubulin mRNA. These results suggest a selective role of APP species which contain the KPI domain in focal cerebral ischemia.

Original languageEnglish
Pages (from-to)172-174
Number of pages3
JournalNeuroscience Letters
Volume125
Issue number2
DOIs
Publication statusPublished - Apr 29 1991
Externally publishedYes

Fingerprint

Amyloid beta-Protein Precursor
Protease Inhibitors
Cerebral Cortex
Ischemia
Messenger RNA
Tubulin
Middle Cerebral Artery Infarction
Brain Ischemia
Northern Blotting

Keywords

  • Alzheimer's disease
  • Amyloid precursor protein
  • Ischemia

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Selective induction of Kunitz-type protease inhibitor domain-containing amyloid precursor protein mRNA after persistent focal ischemia in rat cerebral cortex. / Abe, Koji; Tanzi, Rudolph E.; Kogure, Kyuya.

In: Neuroscience Letters, Vol. 125, No. 2, 29.04.1991, p. 172-174.

Research output: Contribution to journalArticle

@article{941240e3d9f843dc94c2d273168f0e19,
title = "Selective induction of Kunitz-type protease inhibitor domain-containing amyloid precursor protein mRNA after persistent focal ischemia in rat cerebral cortex",
abstract = "An induction of amyloid precursor protein (APP) mRNA was examined in a middle cerebral artery occlusion model of rats using Northern blot analyses. The level of tubulin mRNA was measured as an internal standard. With persistent focal ischemia, APP mRNA species which contain a Kunitz-type protease inhibitor (KPI) domain were induced in the rat cerebral cortex from 1 to 21 days after the insult with a maximum at 4 days, while total amounts of APP mRNA did not change. No change was observed in the level of tubulin mRNA. These results suggest a selective role of APP species which contain the KPI domain in focal cerebral ischemia.",
keywords = "Alzheimer's disease, Amyloid precursor protein, Ischemia",
author = "Koji Abe and Tanzi, {Rudolph E.} and Kyuya Kogure",
year = "1991",
month = "4",
day = "29",
doi = "10.1016/0304-3940(91)90020-T",
language = "English",
volume = "125",
pages = "172--174",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

TY - JOUR

T1 - Selective induction of Kunitz-type protease inhibitor domain-containing amyloid precursor protein mRNA after persistent focal ischemia in rat cerebral cortex

AU - Abe, Koji

AU - Tanzi, Rudolph E.

AU - Kogure, Kyuya

PY - 1991/4/29

Y1 - 1991/4/29

N2 - An induction of amyloid precursor protein (APP) mRNA was examined in a middle cerebral artery occlusion model of rats using Northern blot analyses. The level of tubulin mRNA was measured as an internal standard. With persistent focal ischemia, APP mRNA species which contain a Kunitz-type protease inhibitor (KPI) domain were induced in the rat cerebral cortex from 1 to 21 days after the insult with a maximum at 4 days, while total amounts of APP mRNA did not change. No change was observed in the level of tubulin mRNA. These results suggest a selective role of APP species which contain the KPI domain in focal cerebral ischemia.

AB - An induction of amyloid precursor protein (APP) mRNA was examined in a middle cerebral artery occlusion model of rats using Northern blot analyses. The level of tubulin mRNA was measured as an internal standard. With persistent focal ischemia, APP mRNA species which contain a Kunitz-type protease inhibitor (KPI) domain were induced in the rat cerebral cortex from 1 to 21 days after the insult with a maximum at 4 days, while total amounts of APP mRNA did not change. No change was observed in the level of tubulin mRNA. These results suggest a selective role of APP species which contain the KPI domain in focal cerebral ischemia.

KW - Alzheimer's disease

KW - Amyloid precursor protein

KW - Ischemia

UR - http://www.scopus.com/inward/record.url?scp=0025775107&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025775107&partnerID=8YFLogxK

U2 - 10.1016/0304-3940(91)90020-T

DO - 10.1016/0304-3940(91)90020-T

M3 - Article

VL - 125

SP - 172

EP - 174

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 2

ER -