Selective grignard-type carbonyl addition of alkenyl halides mediated by chromium(II) chloride

Kazuhiko Takai, Keizo Kimura, Tooru Kuroda, Tamejiro Hiyama, Hitosi Nozaki

Research output: Contribution to journalArticle

293 Citations (Scopus)

Abstract

Alkenyl (or aryl) iodide (or bromide) is readily reduced with CrCl2 is N,N-dimethylformamide at 25°C to gice the corresponding organochromium species which adds selectively to an aldehyde moiety without affecting the coexisting ketone or cyano group of the substrate.

Original languageEnglish
Pages (from-to)5281-5284
Number of pages4
JournalTetrahedron Letters
Volume24
Issue number47
DOIs
Publication statusPublished - 1983
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Selective grignard-type carbonyl addition of alkenyl halides mediated by chromium(II) chloride'. Together they form a unique fingerprint.

  • Cite this