Selective grignard-type carbonyl addition of alkenyl halides mediated by chromium(II) chloride

Kazuhiko Takai; Keizo Kimura; Tooru Kuroda; Tamejiro Hiyama; Hitosi Nozaki

doi:10.1016/S0040-4039(00)88417-8

Selective grignard-type carbonyl addition of alkenyl halides mediated by chromium(II) chloride

Kazuhiko Takai, Keizo Kimura, Tooru Kuroda, Tamejiro Hiyama, Hitosi Nozaki

Research output: Contribution to journal › Article

293 Citations (Scopus)

Abstract

Alkenyl (or aryl) iodide (or bromide) is readily reduced with CrCl₂ is N,N-dimethylformamide at 25°C to gice the corresponding organochromium species which adds selectively to an aldehyde moiety without affecting the coexisting ketone or cyano group of the substrate.

Original language	English
Pages (from-to)	5281-5284
Number of pages	4
Journal	Tetrahedron Letters
Volume	24
Issue number	47
DOIs	https://doi.org/10.1016/S0040-4039(00)88417-8
Publication status	Published - 1983
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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Takai, K., Kimura, K., Kuroda, T., Hiyama, T., & Nozaki, H. (1983). Selective grignard-type carbonyl addition of alkenyl halides mediated by chromium(II) chloride. Tetrahedron Letters, 24(47), 5281-5284. https://doi.org/10.1016/S0040-4039(00)88417-8

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abstract = "Alkenyl (or aryl) iodide (or bromide) is readily reduced with CrCl2 is N,N-dimethylformamide at 25°C to gice the corresponding organochromium species which adds selectively to an aldehyde moiety without affecting the coexisting ketone or cyano group of the substrate.",

author = "Kazuhiko Takai and Keizo Kimura and Tooru Kuroda and Tamejiro Hiyama and Hitosi Nozaki",

year = "1983",

doi = "10.1016/S0040-4039(00)88417-8",

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journal = "Tetrahedron Letters",

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T1 - Selective grignard-type carbonyl addition of alkenyl halides mediated by chromium(II) chloride

AU - Takai, Kazuhiko

AU - Kimura, Keizo

AU - Kuroda, Tooru

AU - Hiyama, Tamejiro

AU - Nozaki, Hitosi

PY - 1983

Y1 - 1983

N2 - Alkenyl (or aryl) iodide (or bromide) is readily reduced with CrCl2 is N,N-dimethylformamide at 25°C to gice the corresponding organochromium species which adds selectively to an aldehyde moiety without affecting the coexisting ketone or cyano group of the substrate.

AB - Alkenyl (or aryl) iodide (or bromide) is readily reduced with CrCl2 is N,N-dimethylformamide at 25°C to gice the corresponding organochromium species which adds selectively to an aldehyde moiety without affecting the coexisting ketone or cyano group of the substrate.

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

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