Selective accumulation of rhodacyanine in plasmodial mitochondria is related to the growth inhibition of malaria parasites

Daiki Morisaki; Hye Sook Kim; Hiroshi Inoue; Hiroki Terauchi; Shusuke Kuge; Akira Naganuma; Yusuke Wataya; Hidetoshi Tokuyama; Masataka Ihara; Kiyosei Takasu

doi:10.1039/c0sc00125b

Selective accumulation of rhodacyanine in plasmodial mitochondria is related to the growth inhibition of malaria parasites

Daiki Morisaki, Hye Sook Kim, Hiroshi Inoue, Hiroki Terauchi, Shusuke Kuge, Akira Naganuma, Yusuke Wataya, Hidetoshi Tokuyama, Masataka Ihara, Kiyosei Takasu

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Fluorescent rhodacyanines, which display antimalarial activity in vitro and in vivo, stain plasmodial parasites at the erythrocytic stage. A good correlation between the antimalarial activity and the accumulation of the dyes is observed. A fused-rhodacyanine, which displays a strong fluorescent property itself, was designed as a new probe for plasmodial parasites. It appears to be specifically localized in the parasitic mitochondria.

Original language	English
Pages (from-to)	206-209
Number of pages	4
Journal	Chemical Science
Volume	1
Issue number	2
DOIs	https://doi.org/10.1039/c0sc00125b
Publication status	Published - Aug 2010

ASJC Scopus subject areas

Chemistry(all)

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10.1039/c0sc00125b

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Selective accumulation of rhodacyanine in plasmodial mitochondria is related to the growth inhibition of malaria parasites. / Morisaki, Daiki; Kim, Hye Sook; Inoue, Hiroshi; Terauchi, Hiroki; Kuge, Shusuke; Naganuma, Akira; Wataya, Yusuke; Tokuyama, Hidetoshi; Ihara, Masataka; Takasu, Kiyosei.

In: Chemical Science, Vol. 1, No. 2, 08.2010, p. 206-209.

Research output: Contribution to journal › Article › peer-review

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abstract = "Fluorescent rhodacyanines, which display antimalarial activity in vitro and in vivo, stain plasmodial parasites at the erythrocytic stage. A good correlation between the antimalarial activity and the accumulation of the dyes is observed. A fused-rhodacyanine, which displays a strong fluorescent property itself, was designed as a new probe for plasmodial parasites. It appears to be specifically localized in the parasitic mitochondria.",

author = "Daiki Morisaki and Kim, {Hye Sook} and Hiroshi Inoue and Hiroki Terauchi and Shusuke Kuge and Akira Naganuma and Yusuke Wataya and Hidetoshi Tokuyama and Masataka Ihara and Kiyosei Takasu",

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doi = "10.1039/c0sc00125b",

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AU - Morisaki, Daiki

AU - Kim, Hye Sook

AU - Inoue, Hiroshi

AU - Terauchi, Hiroki

AU - Kuge, Shusuke

AU - Naganuma, Akira

AU - Wataya, Yusuke

AU - Tokuyama, Hidetoshi

AU - Ihara, Masataka

AU - Takasu, Kiyosei

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Selective accumulation of rhodacyanine in plasmodial mitochondria is related to the growth inhibition of malaria parasites

Abstract

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