Selective accumulation of rhodacyanine in plasmodial mitochondria is related to the growth inhibition of malaria parasites

Daiki Morisaki, Hye Sook Kim, Hiroshi Inoue, Hiroki Terauchi, Shusuke Kuge, Akira Naganuma, Yusuke Wataya, Hidetoshi Tokuyama, Masataka Ihara, Kiyosei Takasu

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Abstract

Fluorescent rhodacyanines, which display antimalarial activity in vitro and in vivo, stain plasmodial parasites at the erythrocytic stage. A good correlation between the antimalarial activity and the accumulation of the dyes is observed. A fused-rhodacyanine, which displays a strong fluorescent property itself, was designed as a new probe for plasmodial parasites. It appears to be specifically localized in the parasitic mitochondria.

Original languageEnglish
Pages (from-to)206-209
Number of pages4
JournalChemical Science
Volume1
Issue number2
DOIs
Publication statusPublished - Aug 1 2010

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ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Morisaki, D., Kim, H. S., Inoue, H., Terauchi, H., Kuge, S., Naganuma, A., Wataya, Y., Tokuyama, H., Ihara, M., & Takasu, K. (2010). Selective accumulation of rhodacyanine in plasmodial mitochondria is related to the growth inhibition of malaria parasites. Chemical Science, 1(2), 206-209. https://doi.org/10.1039/c0sc00125b