Selective accumulation of rhodacyanine in plasmodial mitochondria is related to the growth inhibition of malaria parasites

Daiki Morisaki, Hye-Sook Kim, Hiroshi Inoue, Hiroki Terauchi, Shusuke Kuge, Akira Naganuma, Yusuke Wataya, Hidetoshi Tokuyama, Masataka Ihara, Kiyosei Takasu

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Fluorescent rhodacyanines, which display antimalarial activity in vitro and in vivo, stain plasmodial parasites at the erythrocytic stage. A good correlation between the antimalarial activity and the accumulation of the dyes is observed. A fused-rhodacyanine, which displays a strong fluorescent property itself, was designed as a new probe for plasmodial parasites. It appears to be specifically localized in the parasitic mitochondria.

Original languageEnglish
Pages (from-to)206-209
Number of pages4
JournalChemical Science
Volume1
Issue number2
DOIs
Publication statusPublished - Aug 2010

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Mitochondria
Antimalarials
Coloring Agents
Parasites
rhodacyanine

ASJC Scopus subject areas

  • Chemistry(all)

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Selective accumulation of rhodacyanine in plasmodial mitochondria is related to the growth inhibition of malaria parasites. / Morisaki, Daiki; Kim, Hye-Sook; Inoue, Hiroshi; Terauchi, Hiroki; Kuge, Shusuke; Naganuma, Akira; Wataya, Yusuke; Tokuyama, Hidetoshi; Ihara, Masataka; Takasu, Kiyosei.

In: Chemical Science, Vol. 1, No. 2, 08.2010, p. 206-209.

Research output: Contribution to journalArticle

Morisaki, D, Kim, H-S, Inoue, H, Terauchi, H, Kuge, S, Naganuma, A, Wataya, Y, Tokuyama, H, Ihara, M & Takasu, K 2010, 'Selective accumulation of rhodacyanine in plasmodial mitochondria is related to the growth inhibition of malaria parasites', Chemical Science, vol. 1, no. 2, pp. 206-209. https://doi.org/10.1039/c0sc00125b
Morisaki, Daiki ; Kim, Hye-Sook ; Inoue, Hiroshi ; Terauchi, Hiroki ; Kuge, Shusuke ; Naganuma, Akira ; Wataya, Yusuke ; Tokuyama, Hidetoshi ; Ihara, Masataka ; Takasu, Kiyosei. / Selective accumulation of rhodacyanine in plasmodial mitochondria is related to the growth inhibition of malaria parasites. In: Chemical Science. 2010 ; Vol. 1, No. 2. pp. 206-209.
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