Abstract
Fluorescent rhodacyanines, which display antimalarial activity in vitro and in vivo, stain plasmodial parasites at the erythrocytic stage. A good correlation between the antimalarial activity and the accumulation of the dyes is observed. A fused-rhodacyanine, which displays a strong fluorescent property itself, was designed as a new probe for plasmodial parasites. It appears to be specifically localized in the parasitic mitochondria.
| Original language | English |
|---|---|
| Pages (from-to) | 206-209 |
| Number of pages | 4 |
| Journal | Chemical Science |
| Volume | 1 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Aug 2010 |
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ASJC Scopus subject areas
- Chemistry(all)
Cite this
Selective accumulation of rhodacyanine in plasmodial mitochondria is related to the growth inhibition of malaria parasites. / Morisaki, Daiki; Kim, Hye-Sook; Inoue, Hiroshi; Terauchi, Hiroki; Kuge, Shusuke; Naganuma, Akira; Wataya, Yusuke; Tokuyama, Hidetoshi; Ihara, Masataka; Takasu, Kiyosei.
In: Chemical Science, Vol. 1, No. 2, 08.2010, p. 206-209.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Selective accumulation of rhodacyanine in plasmodial mitochondria is related to the growth inhibition of malaria parasites
AU - Morisaki, Daiki
AU - Kim, Hye-Sook
AU - Inoue, Hiroshi
AU - Terauchi, Hiroki
AU - Kuge, Shusuke
AU - Naganuma, Akira
AU - Wataya, Yusuke
AU - Tokuyama, Hidetoshi
AU - Ihara, Masataka
AU - Takasu, Kiyosei
PY - 2010/8
Y1 - 2010/8
N2 - Fluorescent rhodacyanines, which display antimalarial activity in vitro and in vivo, stain plasmodial parasites at the erythrocytic stage. A good correlation between the antimalarial activity and the accumulation of the dyes is observed. A fused-rhodacyanine, which displays a strong fluorescent property itself, was designed as a new probe for plasmodial parasites. It appears to be specifically localized in the parasitic mitochondria.
AB - Fluorescent rhodacyanines, which display antimalarial activity in vitro and in vivo, stain plasmodial parasites at the erythrocytic stage. A good correlation between the antimalarial activity and the accumulation of the dyes is observed. A fused-rhodacyanine, which displays a strong fluorescent property itself, was designed as a new probe for plasmodial parasites. It appears to be specifically localized in the parasitic mitochondria.
UR - http://www.scopus.com/inward/record.url?scp=79961157729&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79961157729&partnerID=8YFLogxK
U2 - 10.1039/c0sc00125b
DO - 10.1039/c0sc00125b
M3 - Article
AN - SCOPUS:79961157729
VL - 1
SP - 206
EP - 209
JO - Chemical Science
JF - Chemical Science
SN - 2041-6520
IS - 2
ER -