Secretion of prostaglandins e2 and F by the bovine endometrium in response to oxytocin during the estrous cycle

Yoko Miyamoto, Dariusz Jan Skarzynski, Yoshihisa Uenoyama, Kiyoshi Okuda

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Secretion of prostaglandins (PG) E2 and PGF by the bovine endometrium and the effects of oxytocin (OT) on these secretions during the estrous cycle were investigated. Bovine uteri were classified into five luteal stages (early I: Days 2-3; early II: Days 5-7; mid-: Days 8-12; late: Days 15-17; regressed: Days 19-21). After l h of pre-incubation, endometrial tissues (20-30 mg) were exposed to 0 or 100 nM OT for 4 h. PGE2 concentration in the medium was higher than that of PGP during the luteal phase, and declined at the regressed luteal stage (P<0.05). In contrast, PGP secretion reached the highest value at the regressed luteal stage (P<0.05). OT significantly stimulated both PGE2 and PGF secretion at the early luteal stage (P<0.05). Although OT enhanced PGP secretion at the late and regressed luteal stages (P<0.05), PGE2 secretion was reduced by OT at the same time (P<0.05). These results indicate that there are significant differences in the pattern of PGE2 and PGF2 secretion by the bovine endometrium during the estrous cycle and suggest that OT may play a role in modulating the secretion of PGE2 as well as PGP.

Original languageEnglish
Pages (from-to)289-295
Number of pages7
JournalJournal of Reproduction and Development
Volume44
Issue number3
DOIs
Publication statusPublished - 1998

Keywords

  • Cattle
  • Endometrium
  • Oxytocin
  • Prostaglandin E
  • Prostaglandin F

ASJC Scopus subject areas

  • Animal Science and Zoology

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