Secondary c-kit mutation in a recurrent gastrointestinal stromal tumor under long-term treatment with imatinib mesylate: Report of a case

Tohru Utsunomiya, Masahiro Okamoto, Shuya Yano, Toshihumi Kameyama, Ayumi Matsuyama, Sosei Kuma, Manabu Yamamoto, Megumu Fujiwara, Teruyoshi Ishida

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11 Citations (Scopus)

Abstract

Gastrointestinal stromal tumors (GISTs) commonly harbor oncogenic mutations of the c-kit receptor gene, which are targets for imatinib mesylate. However, imatinib resistance is an increasing clinical problem. We herein present such a case with a recurrent GIST, in association with the development of a secondary mutation in the c-kit gene. A 67-year-old man, who had a GIST of the stomach with multiple liver metastases, underwent a partial gastrectomy, distal pancreatectomy, and partial hepatectomy. After surgery, he was treated with imatinib. However, during the approximately 4-year treatment period, a recurrence of the GIST in the liver was detected, for which a partial hepatectomy was again performed. The primary GIST constitutively had a deletion mutation in exon 11. In addition, the recurrent hepatic tumor developed a secondary point mutation (Val654Ala) in exon 13, which may be responsible for the imatinib resistance.

Original languageEnglish
Pages (from-to)65-67
Number of pages3
JournalSurgery today
Volume38
Issue number1
DOIs
Publication statusPublished - Jan 2008
Externally publishedYes

Keywords

  • Gastrointestinal stromal tumor
  • Imatinib resistance
  • Liver metastasis
  • Recurrence
  • Secondary mutation

ASJC Scopus subject areas

  • Surgery

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    Utsunomiya, T., Okamoto, M., Yano, S., Kameyama, T., Matsuyama, A., Kuma, S., Yamamoto, M., Fujiwara, M., & Ishida, T. (2008). Secondary c-kit mutation in a recurrent gastrointestinal stromal tumor under long-term treatment with imatinib mesylate: Report of a case. Surgery today, 38(1), 65-67. https://doi.org/10.1007/s00595-007-3559-8