Second nationwide surveillance of bacterial pathogens in patients with acute uncomplicated cystitis conducted by Japanese Surveillance Committee from 2015 to 2016

antimicrobial susceptibility of Escherichia coli, Klebsiella pneumoniae, and Staphylococcus saprophyticus

Hiroshi Hayami, Satoshi Takahashi, Kiyohito Ishikawa, Mitsuru Yasuda, Shingo Yamamoto, Koichiro Wada, Kanao Kobayashi, Ryoichi Hamasuna, Shinichi Minamitani, Tetsuya Matsumoto, Hiroshi Kiyota, Kazuhiro Tateda, Junko Sato, Hideaki Hanaki, Naoya Masumori, Hiroyuki Nishiyama, Jun Miyazaki, Kiyohide Fujimoto, Kazushi Tanaka, Shinya Uehara & 33 others Akio Matsubara, Kenji Ito, Kenji Hayashi, Yuichiro Kurimura, Shin Ito, Toshimi Takeuchi, Harunori Narita, Masanobu Izumitani, Hirofumi Nishimura, Motoshi Kawahara, Makoto Hara, Takahide Hosobe, Kenji Takashima, Hirofumi Chokyu, Masaru Matsumura, Hideari Ihara, Satoshi Uno, Koichi Monden, Toru Sumii, Shuichi Kawai, Satoru Kariya, Takashi Sato, Masaru Yoshioka, Hitoshi Kadena, Shinji Matsushita, Shohei Nishi, Yukinari Hosokawa, Takeshi Shirane, Mutsumasa Yoh, Syuji Watanabe, Shinichi Makinose, Tetsuji Uemura, Hirokazu Goto

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The Japanese Surveillance Committee conducted a second nationwide surveillance of antimicrobial susceptibility patterns of uropathogens responsible for acute uncomplicated cystitis (AUC) in premenopausal patients aged 16–40 years old at 31 hospitals throughout Japan from March 2015 to February 2016. In this study, the susceptibility of causative bacteria (Escherichia coli, Klebsiella pneumoniae, Staphylococcus saprophyticus) for various antimicrobial agents was investigated by isolation and culturing of organisms obtained from urine samples. In total, 324 strains were isolated from 361 patients, including E. coli (n = 220, 67.9%), S. saprophyticus (n = 36, 11.1%), and K. pneumoniae (n = 7, 2.2%). The minimum inhibitory concentrations (MICs) of 20 antibacterial agents for these strains were determined according to the Clinical and Laboratory Standards Institute (CLSI) manual. At least 93% of the E. coli isolates showed susceptibility to fluoroquinolones and cephalosporins, whereas 100% of the S. saprophyticus isolates showed susceptibility to fluoroquinolones and aminoglycosides. The proportions of fluoroquinolone-resistant and extended-spectrum β-lactamase (ESBL)-producing E. coli strains were 6.4% (13/220) and 4.1% (9/220), respectively. The antimicrobial susceptibility of K. pneumoniae was retained during the surveillance period, while no multidrug-resistant strains were identified. In summary, antimicrobial susceptibility results of our second nationwide surveillance did not differ significantly from those of the first surveillance. Especially the numbers of fluoroquinolone-resistant and ESBL-producing E. coli strains were not increased in premenopausal patients with AUC in Japan.

Original languageEnglish
Pages (from-to)413-422
Number of pages10
JournalJournal of Infection and Chemotherapy
Volume25
Issue number6
DOIs
Publication statusPublished - Jun 1 2019

Fingerprint

Staphylococcus saprophyticus
Cystitis
Klebsiella pneumoniae
Fluoroquinolones
Escherichia coli
Japan
Microbial Sensitivity Tests
Aminoglycosides
Cephalosporins
Anti-Infective Agents
Urine
Anti-Bacterial Agents
Bacteria

Keywords

  • Acute uncomplicated cystitis
  • Resistance
  • Surveillance
  • Susceptibility

ASJC Scopus subject areas

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Second nationwide surveillance of bacterial pathogens in patients with acute uncomplicated cystitis conducted by Japanese Surveillance Committee from 2015 to 2016 : antimicrobial susceptibility of Escherichia coli, Klebsiella pneumoniae, and Staphylococcus saprophyticus. / Hayami, Hiroshi; Takahashi, Satoshi; Ishikawa, Kiyohito; Yasuda, Mitsuru; Yamamoto, Shingo; Wada, Koichiro; Kobayashi, Kanao; Hamasuna, Ryoichi; Minamitani, Shinichi; Matsumoto, Tetsuya; Kiyota, Hiroshi; Tateda, Kazuhiro; Sato, Junko; Hanaki, Hideaki; Masumori, Naoya; Nishiyama, Hiroyuki; Miyazaki, Jun; Fujimoto, Kiyohide; Tanaka, Kazushi; Uehara, Shinya; Matsubara, Akio; Ito, Kenji; Hayashi, Kenji; Kurimura, Yuichiro; Ito, Shin; Takeuchi, Toshimi; Narita, Harunori; Izumitani, Masanobu; Nishimura, Hirofumi; Kawahara, Motoshi; Hara, Makoto; Hosobe, Takahide; Takashima, Kenji; Chokyu, Hirofumi; Matsumura, Masaru; Ihara, Hideari; Uno, Satoshi; Monden, Koichi; Sumii, Toru; Kawai, Shuichi; Kariya, Satoru; Sato, Takashi; Yoshioka, Masaru; Kadena, Hitoshi; Matsushita, Shinji; Nishi, Shohei; Hosokawa, Yukinari; Shirane, Takeshi; Yoh, Mutsumasa; Watanabe, Syuji; Makinose, Shinichi; Uemura, Tetsuji; Goto, Hirokazu.

In: Journal of Infection and Chemotherapy, Vol. 25, No. 6, 01.06.2019, p. 413-422.

Research output: Contribution to journalArticle

Hayami, H, Takahashi, S, Ishikawa, K, Yasuda, M, Yamamoto, S, Wada, K, Kobayashi, K, Hamasuna, R, Minamitani, S, Matsumoto, T, Kiyota, H, Tateda, K, Sato, J, Hanaki, H, Masumori, N, Nishiyama, H, Miyazaki, J, Fujimoto, K, Tanaka, K, Uehara, S, Matsubara, A, Ito, K, Hayashi, K, Kurimura, Y, Ito, S, Takeuchi, T, Narita, H, Izumitani, M, Nishimura, H, Kawahara, M, Hara, M, Hosobe, T, Takashima, K, Chokyu, H, Matsumura, M, Ihara, H, Uno, S, Monden, K, Sumii, T, Kawai, S, Kariya, S, Sato, T, Yoshioka, M, Kadena, H, Matsushita, S, Nishi, S, Hosokawa, Y, Shirane, T, Yoh, M, Watanabe, S, Makinose, S, Uemura, T & Goto, H 2019, 'Second nationwide surveillance of bacterial pathogens in patients with acute uncomplicated cystitis conducted by Japanese Surveillance Committee from 2015 to 2016: antimicrobial susceptibility of Escherichia coli, Klebsiella pneumoniae, and Staphylococcus saprophyticus', Journal of Infection and Chemotherapy, vol. 25, no. 6, pp. 413-422. https://doi.org/10.1016/j.jiac.2019.02.021
Hayami, Hiroshi ; Takahashi, Satoshi ; Ishikawa, Kiyohito ; Yasuda, Mitsuru ; Yamamoto, Shingo ; Wada, Koichiro ; Kobayashi, Kanao ; Hamasuna, Ryoichi ; Minamitani, Shinichi ; Matsumoto, Tetsuya ; Kiyota, Hiroshi ; Tateda, Kazuhiro ; Sato, Junko ; Hanaki, Hideaki ; Masumori, Naoya ; Nishiyama, Hiroyuki ; Miyazaki, Jun ; Fujimoto, Kiyohide ; Tanaka, Kazushi ; Uehara, Shinya ; Matsubara, Akio ; Ito, Kenji ; Hayashi, Kenji ; Kurimura, Yuichiro ; Ito, Shin ; Takeuchi, Toshimi ; Narita, Harunori ; Izumitani, Masanobu ; Nishimura, Hirofumi ; Kawahara, Motoshi ; Hara, Makoto ; Hosobe, Takahide ; Takashima, Kenji ; Chokyu, Hirofumi ; Matsumura, Masaru ; Ihara, Hideari ; Uno, Satoshi ; Monden, Koichi ; Sumii, Toru ; Kawai, Shuichi ; Kariya, Satoru ; Sato, Takashi ; Yoshioka, Masaru ; Kadena, Hitoshi ; Matsushita, Shinji ; Nishi, Shohei ; Hosokawa, Yukinari ; Shirane, Takeshi ; Yoh, Mutsumasa ; Watanabe, Syuji ; Makinose, Shinichi ; Uemura, Tetsuji ; Goto, Hirokazu. / Second nationwide surveillance of bacterial pathogens in patients with acute uncomplicated cystitis conducted by Japanese Surveillance Committee from 2015 to 2016 : antimicrobial susceptibility of Escherichia coli, Klebsiella pneumoniae, and Staphylococcus saprophyticus. In: Journal of Infection and Chemotherapy. 2019 ; Vol. 25, No. 6. pp. 413-422.
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abstract = "The Japanese Surveillance Committee conducted a second nationwide surveillance of antimicrobial susceptibility patterns of uropathogens responsible for acute uncomplicated cystitis (AUC) in premenopausal patients aged 16–40 years old at 31 hospitals throughout Japan from March 2015 to February 2016. In this study, the susceptibility of causative bacteria (Escherichia coli, Klebsiella pneumoniae, Staphylococcus saprophyticus) for various antimicrobial agents was investigated by isolation and culturing of organisms obtained from urine samples. In total, 324 strains were isolated from 361 patients, including E. coli (n = 220, 67.9{\%}), S. saprophyticus (n = 36, 11.1{\%}), and K. pneumoniae (n = 7, 2.2{\%}). The minimum inhibitory concentrations (MICs) of 20 antibacterial agents for these strains were determined according to the Clinical and Laboratory Standards Institute (CLSI) manual. At least 93{\%} of the E. coli isolates showed susceptibility to fluoroquinolones and cephalosporins, whereas 100{\%} of the S. saprophyticus isolates showed susceptibility to fluoroquinolones and aminoglycosides. The proportions of fluoroquinolone-resistant and extended-spectrum β-lactamase (ESBL)-producing E. coli strains were 6.4{\%} (13/220) and 4.1{\%} (9/220), respectively. The antimicrobial susceptibility of K. pneumoniae was retained during the surveillance period, while no multidrug-resistant strains were identified. In summary, antimicrobial susceptibility results of our second nationwide surveillance did not differ significantly from those of the first surveillance. Especially the numbers of fluoroquinolone-resistant and ESBL-producing E. coli strains were not increased in premenopausal patients with AUC in Japan.",
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T1 - Second nationwide surveillance of bacterial pathogens in patients with acute uncomplicated cystitis conducted by Japanese Surveillance Committee from 2015 to 2016

T2 - antimicrobial susceptibility of Escherichia coli, Klebsiella pneumoniae, and Staphylococcus saprophyticus

AU - Hayami, Hiroshi

AU - Takahashi, Satoshi

AU - Ishikawa, Kiyohito

AU - Yasuda, Mitsuru

AU - Yamamoto, Shingo

AU - Wada, Koichiro

AU - Kobayashi, Kanao

AU - Hamasuna, Ryoichi

AU - Minamitani, Shinichi

AU - Matsumoto, Tetsuya

AU - Kiyota, Hiroshi

AU - Tateda, Kazuhiro

AU - Sato, Junko

AU - Hanaki, Hideaki

AU - Masumori, Naoya

AU - Nishiyama, Hiroyuki

AU - Miyazaki, Jun

AU - Fujimoto, Kiyohide

AU - Tanaka, Kazushi

AU - Uehara, Shinya

AU - Matsubara, Akio

AU - Ito, Kenji

AU - Hayashi, Kenji

AU - Kurimura, Yuichiro

AU - Ito, Shin

AU - Takeuchi, Toshimi

AU - Narita, Harunori

AU - Izumitani, Masanobu

AU - Nishimura, Hirofumi

AU - Kawahara, Motoshi

AU - Hara, Makoto

AU - Hosobe, Takahide

AU - Takashima, Kenji

AU - Chokyu, Hirofumi

AU - Matsumura, Masaru

AU - Ihara, Hideari

AU - Uno, Satoshi

AU - Monden, Koichi

AU - Sumii, Toru

AU - Kawai, Shuichi

AU - Kariya, Satoru

AU - Sato, Takashi

AU - Yoshioka, Masaru

AU - Kadena, Hitoshi

AU - Matsushita, Shinji

AU - Nishi, Shohei

AU - Hosokawa, Yukinari

AU - Shirane, Takeshi

AU - Yoh, Mutsumasa

AU - Watanabe, Syuji

AU - Makinose, Shinichi

AU - Uemura, Tetsuji

AU - Goto, Hirokazu

PY - 2019/6/1

Y1 - 2019/6/1

N2 - The Japanese Surveillance Committee conducted a second nationwide surveillance of antimicrobial susceptibility patterns of uropathogens responsible for acute uncomplicated cystitis (AUC) in premenopausal patients aged 16–40 years old at 31 hospitals throughout Japan from March 2015 to February 2016. In this study, the susceptibility of causative bacteria (Escherichia coli, Klebsiella pneumoniae, Staphylococcus saprophyticus) for various antimicrobial agents was investigated by isolation and culturing of organisms obtained from urine samples. In total, 324 strains were isolated from 361 patients, including E. coli (n = 220, 67.9%), S. saprophyticus (n = 36, 11.1%), and K. pneumoniae (n = 7, 2.2%). The minimum inhibitory concentrations (MICs) of 20 antibacterial agents for these strains were determined according to the Clinical and Laboratory Standards Institute (CLSI) manual. At least 93% of the E. coli isolates showed susceptibility to fluoroquinolones and cephalosporins, whereas 100% of the S. saprophyticus isolates showed susceptibility to fluoroquinolones and aminoglycosides. The proportions of fluoroquinolone-resistant and extended-spectrum β-lactamase (ESBL)-producing E. coli strains were 6.4% (13/220) and 4.1% (9/220), respectively. The antimicrobial susceptibility of K. pneumoniae was retained during the surveillance period, while no multidrug-resistant strains were identified. In summary, antimicrobial susceptibility results of our second nationwide surveillance did not differ significantly from those of the first surveillance. Especially the numbers of fluoroquinolone-resistant and ESBL-producing E. coli strains were not increased in premenopausal patients with AUC in Japan.

AB - The Japanese Surveillance Committee conducted a second nationwide surveillance of antimicrobial susceptibility patterns of uropathogens responsible for acute uncomplicated cystitis (AUC) in premenopausal patients aged 16–40 years old at 31 hospitals throughout Japan from March 2015 to February 2016. In this study, the susceptibility of causative bacteria (Escherichia coli, Klebsiella pneumoniae, Staphylococcus saprophyticus) for various antimicrobial agents was investigated by isolation and culturing of organisms obtained from urine samples. In total, 324 strains were isolated from 361 patients, including E. coli (n = 220, 67.9%), S. saprophyticus (n = 36, 11.1%), and K. pneumoniae (n = 7, 2.2%). The minimum inhibitory concentrations (MICs) of 20 antibacterial agents for these strains were determined according to the Clinical and Laboratory Standards Institute (CLSI) manual. At least 93% of the E. coli isolates showed susceptibility to fluoroquinolones and cephalosporins, whereas 100% of the S. saprophyticus isolates showed susceptibility to fluoroquinolones and aminoglycosides. The proportions of fluoroquinolone-resistant and extended-spectrum β-lactamase (ESBL)-producing E. coli strains were 6.4% (13/220) and 4.1% (9/220), respectively. The antimicrobial susceptibility of K. pneumoniae was retained during the surveillance period, while no multidrug-resistant strains were identified. In summary, antimicrobial susceptibility results of our second nationwide surveillance did not differ significantly from those of the first surveillance. Especially the numbers of fluoroquinolone-resistant and ESBL-producing E. coli strains were not increased in premenopausal patients with AUC in Japan.

KW - Acute uncomplicated cystitis

KW - Resistance

KW - Surveillance

KW - Susceptibility

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