Search for Naturally-occurring Antioxidative Chemopreventors on the Basis of the Involvement of Leukocyte-derived Reactive Oxygen Species in Carcinogenesis

Yoshimasa Nakamura, Akira Murakami, Hajime Ohigashi

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Chemoprevention with food phytochemicals is currently regarded as one of the most attractive strategies for cancer control. We have been continuously working on the identification and characterization of chemopreventive phytochemicals extracted from a diverse range of edible plants. Recently, we have utilized a convenient assay, the tumor promoter-induced superoxide generation test, with differentiated HL-60 cells for primary screening, and performed chemical studies of antioxidative food phytochemicals. Here, we report our criteria for evaluation of new types of chemopreventors on the basis of the involvement of leukocyte-derived reactive oxygen in carcinogenesis.

Original languageEnglish
Pages (from-to)115-120
Number of pages6
JournalAsian Pacific journal of cancer prevention : APJCP
Volume1
Issue number2
Publication statusPublished - 2000
Externally publishedYes

Fingerprint

Phytochemicals
Reactive Oxygen Species
Carcinogenesis
Leukocytes
Food
Edible Plants
HL-60 Cells
Chemoprevention
Superoxides
Carcinogens
Oxygen
Neoplasms

Keywords

  • Antioxidant
  • Chemoprevention
  • Inflammation
  • Leukocyte
  • Phytochemicals
  • Reactive oxygen species

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Public Health, Environmental and Occupational Health
  • Epidemiology

Cite this

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AU - Ohigashi, Hajime

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