Search for biomarkers of asbestos exposure and asbestos-induced cancers in investigations of the immunological effects of asbestos

Hidenori Matsuzaki, Naoko Kumagai-Takei, Suni Lee, Megumi Maeda, Nagisa Sada, Tamayo Hatayama, Shoko Yamamoto, Miho Ikeda, Kei Yoshitome, Yu Min, Yasumitsu Nishimura, Takemi Otsuki

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

The immunological effects of asbestos exposure on various lymphocytes such as the regulatory T cell (Treg), responder CD4+ T helper cell (Tresp), CD8+ cytotoxic T lymphocytes (CTL), and natural killer (NK) cells were investigated. Results show that asbestos exposure impairs antitumor immunity through enhancement of regulatory T cell function and volume, reduction of CXCR3 chemokine receptor in responder CD4+ T helper cells, and impairment of the killing activities of CD8+ cytotoxic T lymphocytes (CTL) and NK cells. These findings were used to explore biological markers associated with asbestos exposure and asbestos-induced cancers and suggested the usefulness of serum/plasma IL-10 and TGF-ß, surface CXCR3 expression in Tresp, the secreting potential of IFN-γ in Tresp, intracellular perforin level in CTL, and surface expression NKp46 in NK cells. Although other unexplored cytokines in serum/plasma and molecules in these immunological cells, including Th17, should be investigated by experimental procedures in addition to a comprehensive analysis of screening methods, biomarkers based on immunological alterations may be helpful in clinical situations to screen the high-risk population exposed to asbestos and susceptible to asbestos-related cancers such as mesothelioma.

Original languageEnglish
JournalEnvironmental Health and Preventive Medicine
Volume22
Issue number1
DOIs
Publication statusPublished - 2017

Fingerprint

Asbestos
Biomarkers
Cytotoxic T-Lymphocytes
Natural Killer Cells
Neoplasms
Regulatory T-Lymphocytes
Helper-Inducer T-Lymphocytes
CXCR3 Receptors
Th17 Cells
Perforin
Chemokine Receptors
Mesothelioma
Serum
Cell Size
Interleukin-10
Immunity
Lymphocytes
Cytokines
Population

Keywords

  • Asbestos
  • Biomarker
  • Cell surface marker
  • Cytokine
  • Immune cells
  • Tumor immunity

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Search for biomarkers of asbestos exposure and asbestos-induced cancers in investigations of the immunological effects of asbestos. / Matsuzaki, Hidenori; Kumagai-Takei, Naoko; Lee, Suni; Maeda, Megumi; Sada, Nagisa; Hatayama, Tamayo; Yamamoto, Shoko; Ikeda, Miho; Yoshitome, Kei; Min, Yu; Nishimura, Yasumitsu; Otsuki, Takemi.

In: Environmental Health and Preventive Medicine, Vol. 22, No. 1, 2017.

Research output: Contribution to journalReview article

Matsuzaki, H, Kumagai-Takei, N, Lee, S, Maeda, M, Sada, N, Hatayama, T, Yamamoto, S, Ikeda, M, Yoshitome, K, Min, Y, Nishimura, Y & Otsuki, T 2017, 'Search for biomarkers of asbestos exposure and asbestos-induced cancers in investigations of the immunological effects of asbestos', Environmental Health and Preventive Medicine, vol. 22, no. 1. https://doi.org/10.1186/s12199-017-0661-4
Matsuzaki, Hidenori ; Kumagai-Takei, Naoko ; Lee, Suni ; Maeda, Megumi ; Sada, Nagisa ; Hatayama, Tamayo ; Yamamoto, Shoko ; Ikeda, Miho ; Yoshitome, Kei ; Min, Yu ; Nishimura, Yasumitsu ; Otsuki, Takemi. / Search for biomarkers of asbestos exposure and asbestos-induced cancers in investigations of the immunological effects of asbestos. In: Environmental Health and Preventive Medicine. 2017 ; Vol. 22, No. 1.
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