Screening for DNA copy number aberrations in mucinous adenocarcinoma arising from the minor salivary gland: Two case reports

Kenichiro Uchida, Atsunori Oga, Takamitsu Mano, Hitoshi Nagatsuka, Yoshiya Ueyama, Kohsuke Sasaki

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Mucinous adenocarcinoma (MAC) is a rare malignancy in the minor salivary gland. To our knowledge, genomic alterations in this tumor have not been reported previously. To identify DNA copy number aberrations, we applied comparative genomic hybridization (CGH) to four samples of MAC in minor salivary gland derived from two patients: a primary tumor and two cervical metastatic lymph nodes from one patient, and a primary tumor from the other patient. Copy number increases were commonly detected in 1q21∼q31 and 20q13, and these may play an important role in MAC carcinogenesis. Copy number increases in 1q, 12p, 12q, and 20q were commonly detected in all three samples derived from patient 1, and gain of 7p and loss of chromosome 4 were additionally detected in the two samples derived from metastatic lymph nodes. Amplifications were also detected in the chromosomal regions 8q22∼qter, 12p11∼p12, 12q11∼q21, and 20q13. Amplification of MDM2 (12q15) and of AURKA (20q13) was detected with fluorescence in situ hybridization. The DNA copy number aberrations detected in MAC in minor salivary glands were different from those reported for colorectal MAC. The present findings are novel in identifying genomic alterations of MAC arising from the minor salivary gland.

Original languageEnglish
Pages (from-to)324-327
Number of pages4
JournalCancer Genetics and Cytogenetics
Volume203
Issue number2
DOIs
Publication statusPublished - Dec 2010

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ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

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