Scalp-recorded high-frequency oscillations in childhood sleep-induced electrical status epilepticus

Katsuhiro Kobayashi, Yoshiaki Watanabe, Takushi Inoue, Makio Oka, Harumi Yoshinaga, Yoko Ohtsuka

Research output: Contribution to journalArticle

87 Citations (Scopus)

Abstract

Because high-frequency oscillations (HFOs) may affect normal brain functions, we examined them using electroencephalography (EEG) in epilepsy with continuous spike-waves during slow-wave sleep (CSWS), a condition that can cause neuropsychological regression. In 10 children between 6 and 9 years of age with epilepsy with CSWS or related disorders, we investigated HFOs in scalp EEG spikes during slow-wave sleep through temporal expansion of the EEG traces with a low-cut frequency filter at 70 Hz as well as through time-frequency power spectral analysis. HFOs (ripples) concurrent with spikes were detected in the temporally expanded traces, and the frequency of the high-frequency peak with the greatest power in each patient's spectra ranged from 97.7 to 140.6 Hz. This is the first report on the detection of HFOs from scalp EEG recordings in epileptic patients. We speculate that epileptic HFOs may interfere with higher brain functions in epilepsy with CSWS.

Original languageEnglish
Pages (from-to)2190-2194
Number of pages5
JournalEpilepsia
Volume51
Issue number10
DOIs
Publication statusPublished - Oct 2010

Keywords

  • Childhood
  • Continuous spike-waves during slow-wave sleep
  • EEG
  • High-frequency oscillations
  • Landau-Kleffner syndrome
  • Time-frequency analysis

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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