Sarcoid-like lung granulomas in a hemodialysis patient treated with a dipeptidyl peptidase-4 inhibitor

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3 Citations (Scopus)

Abstract

It has been reported that the inhibition of dipeptidyl peptidase-4 (DPP-4)/CD26 on T-cells by DPP-4 enzymatic inhibitors suppresses lymphocyte proliferation and reduces the production of various cytokines, including tumor necrosis factor (TNF)-α. A 72-year-old female with diabetic nephropathy on hemodialysis developed multiple lung nodules following the administration of vildagliptin. A biopsy demonstrated the histology of granulomas without caseous necrosis. The discontinuation of vildagliptin resulted in the disappearance of the granulomas within 4 months. As granulomatosis often develops in patients under anti-TNF-α therapy, the accumulation of DPP-4 inhibitors or its metabolites is possibly linked to unrecognized complications, such as sarcoid-like lung granulomas.

Original languageEnglish
Pages (from-to)182-185
Number of pages4
JournalClinical Kidney Journal
Volume7
Issue number2
DOIs
Publication statusPublished - Apr 2014

Keywords

  • dipeptidyl peptidase-4 inhibitor
  • granuloma
  • hemodialysis
  • vildagliptin

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

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