Abstract
It has been reported that the inhibition of dipeptidyl peptidase-4 (DPP-4)/CD26 on T-cells by DPP-4 enzymatic inhibitors suppresses lymphocyte proliferation and reduces the production of various cytokines, including tumor necrosis factor (TNF)-α. A 72-year-old female with diabetic nephropathy on hemodialysis developed multiple lung nodules following the administration of vildagliptin. A biopsy demonstrated the histology of granulomas without caseous necrosis. The discontinuation of vildagliptin resulted in the disappearance of the granulomas within 4 months. As granulomatosis often develops in patients under anti-TNF-α therapy, the accumulation of DPP-4 inhibitors or its metabolites is possibly linked to unrecognized complications, such as sarcoid-like lung granulomas.
Original language | English |
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Pages (from-to) | 182-185 |
Number of pages | 4 |
Journal | Clinical Kidney Journal |
Volume | 7 |
Issue number | 2 |
DOIs | |
Publication status | Published - Apr 2014 |
Keywords
- dipeptidyl peptidase-4 inhibitor
- granuloma
- hemodialysis
- vildagliptin
ASJC Scopus subject areas
- Nephrology
- Transplantation