Safety of and tolerance to adenosine infusion for myocardial perfusion single-photon emission computed tomography in a Japanese population

Kunihiko Hatanaka, Masayuki Doi, Satoshi Hirohata, Shigeshi Kamikawa, Yoko Kaji, Tsutomu Katoh, Shozo Kusachi, Yoshifumi Ninomiya, Tohru Ohe

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: Adenosine has been available for use in myocardial perfusion single-photon emission computed tomography (SPECT) in Japan since 2005. The purpose of this study was to evaluate the safety of and tolerance to thallium-201 myocardial perfusion SPECT with intravenous adenosine infusion in Japanese patients with suspected coronary artery disease. Methods and Results: Two hundred and six consecutive patients who underwent an adenosine infusion (120•g•·kg-1·min-1) SPECT at Sumitomo Besshi Hospital (Niihama, Japan) were investigated. The effects of adenosine infusion were monitored for each patient. A coronary angiography was performed in 81 patients. Adenosine infusion significantly decreased blood pressure and increased heart rate. Adverse reactions were observed in 161 patients (78.2%). Most reactions were transient, disappearing soon after the termination of adenosine infusion. No serious adverse reactions, such as acute myocardial infarction or death, occurred. Adenosine infusion was terminated in 3 patients (1.5%) because of near syncope or sustained 2:1 atrioventricular block. Electrocardiographic changes occurred in 15 patients (7.3%). Self-assessed scoring after SPECT showed that the patients were very tolerant (74.6% of 177 patients) of adenosine infusion myocardial SPECT. The sensitivity and specificity were 75.0% and 69.7%, respectively. Conclusions: Adenosine infusion myocardial SPECT is safe and well tolerated in the Japanese population, despite the frequent occurrence of minor adverse reactions.

Original languageEnglish
Pages (from-to)904-910
Number of pages7
JournalCirculation Journal
Volume71
Issue number6
DOIs
Publication statusPublished - Jun 4 2007

Keywords

  • Adenosine
  • Coronary heart disease
  • Japanese
  • Pharmacologic stress

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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