Safety Assessment of Botanicals and Botanical Preparations Used as Ingredients in Food Supplements: Testing an European Food Safety Authority-Tiered ApproachThe Japanese Toxicogenomics Project: Application of Toxicogenomics - Utilizing Toxicogenomics into Drug Safety Screening

Takeki Uehara, Atsushi Ono, Toshiyuki Maruyama, Ikuo Kato, Hiroshi Yamada, Yasuo Ohno, Tetsuro Urushidani

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Biotechnology advances have provided novel methods for the risk assessment of chemicals. The application of microarray technologies to toxicology, known as toxicogenomics, is becoming an accepted approach for identifying chemicals with potential safety problems. Gene expression profiling is expected to identify the mechanisms that underlie the potential toxicity of chemicals. This technology has also been applied to identify biomarkers of toxicity to predict potential hazardous chemicals. Ultimately, toxicogenomics is expected to aid in risk assessment. The following discussion explores potential applications and features of the Japanese toxicogenomics project.

Original languageEnglish
Title of host publicationRisk Assessment of Phytochemicals in Food
Subtitle of host publicationNovel Approaches
PublisherWiley-Blackwell
Pages254-271
Number of pages18
ISBN (Print)9783527329298
DOIs
Publication statusPublished - Dec 15 2010
Externally publishedYes

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Keywords

  • Carcinogen specific expression profiling
  • Genomics biomarkers
  • Profiling techniques
  • Safety testing
  • Toxicogenomics

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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