Abstract
A novel and practical oxidation of alcohols to carbonyl compounds using NaOCl in the presence of catalytic amounts of imide compound and nitroxyl radical has been developed. A wide variety of aliphatic, benzylic primary alcohols, and secondary alcohols were oxidized to afford the corresponding aldehydes and ketones in up to 98% yield without undesired halogenation on aromatic rings or double bonds. The oxidation safely proceeded not only in the presence of K2CO3 but also by a slow addition of NaOCl without tedious pH adjustment.
Original language | English |
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Pages (from-to) | 3905-3908 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 56 |
Issue number | 25 |
DOIs | |
Publication status | Published - May 30 2015 |
Keywords
- Alcohol
- Imide
- NaOCl
- Nitroxyl radical
- Oxidation
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry