S100A11, an dual mediator for growth regulation of human keratinocytes

Masakiyo Sakaguchi, Hiroyuki Sonegawa, Hitoshi Murata, Midori Kitazoe, Junichiro Futami, Ken Kataoka, Hidenori Yamada, Nam Ho Huh

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

We previously revealed a novel signal pathway involving S100A11 for inhibition of the growth of normal human keratinocytes (NHK) caused by high Ca++ or transforming growth factor β. Exposure to either agent resulted in transfer of S100A11 to nuclei, where it induced p21WAF1. In contrast, S100A11 has been shown to be overexpressed in many human cancers. To address this apparent discrepancy, we analyzed possible new functions of S100A11, and we provide herein evidence that 1) S100A11 is actively secreted by NHK; 2) extracellular S100A11 acts on NHK to enhance the production of epidermal growth factor family proteins, resulting in growth stimulation; 3) receptor for advanced glycation end products, nuclear factor-κB, Akt, and cAMP response element-binding protein are involved in the S100A11-triggered signal transduction; and 4) production and secretion of S100A11 are markedly enhanced in human squamous cancer cells. These findings indicate that S100A11 plays a dual role in growth regulation of epithelial cells.

Original languageEnglish
Pages (from-to)78-85
Number of pages8
JournalMolecular Biology of the Cell
Volume19
Issue number1
DOIs
Publication statusPublished - Jan 2008

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Keratinocytes
Growth
Signal Transduction
Cyclic AMP Response Element-Binding Protein
Squamous Cell Neoplasms
Transforming Growth Factors
Epidermal Growth Factor
Epithelial Cells
Neoplasms
Proteins

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cell Biology

Cite this

S100A11, an dual mediator for growth regulation of human keratinocytes. / Sakaguchi, Masakiyo; Sonegawa, Hiroyuki; Murata, Hitoshi; Kitazoe, Midori; Futami, Junichiro; Kataoka, Ken; Yamada, Hidenori; Huh, Nam Ho.

In: Molecular Biology of the Cell, Vol. 19, No. 1, 01.2008, p. 78-85.

Research output: Contribution to journalArticle

Sakaguchi, Masakiyo ; Sonegawa, Hiroyuki ; Murata, Hitoshi ; Kitazoe, Midori ; Futami, Junichiro ; Kataoka, Ken ; Yamada, Hidenori ; Huh, Nam Ho. / S100A11, an dual mediator for growth regulation of human keratinocytes. In: Molecular Biology of the Cell. 2008 ; Vol. 19, No. 1. pp. 78-85.
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