Abstract
We previously revealed a novel signal pathway involving S100A11 for inhibition of the growth of normal human keratinocytes (NHK) caused by high Ca++ or transforming growth factor β. Exposure to either agent resulted in transfer of S100A11 to nuclei, where it induced p21WAF1. In contrast, S100A11 has been shown to be overexpressed in many human cancers. To address this apparent discrepancy, we analyzed possible new functions of S100A11, and we provide herein evidence that 1) S100A11 is actively secreted by NHK; 2) extracellular S100A11 acts on NHK to enhance the production of epidermal growth factor family proteins, resulting in growth stimulation; 3) receptor for advanced glycation end products, nuclear factor-κB, Akt, and cAMP response element-binding protein are involved in the S100A11-triggered signal transduction; and 4) production and secretion of S100A11 are markedly enhanced in human squamous cancer cells. These findings indicate that S100A11 plays a dual role in growth regulation of epithelial cells.
| Original language | English |
|---|---|
| Pages (from-to) | 78-85 |
| Number of pages | 8 |
| Journal | Molecular Biology of the Cell |
| Volume | 19 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 2008 |
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ASJC Scopus subject areas
- Molecular Biology
- Genetics
- Cell Biology
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S100A11, an dual mediator for growth regulation of human keratinocytes. / Sakaguchi, Masakiyo; Sonegawa, Hiroyuki; Murata, Hitoshi; Kitazoe, Midori; Futami, Junichiro; Kataoka, Ken; Yamada, Hidenori; Huh, Nam Ho.
In: Molecular Biology of the Cell, Vol. 19, No. 1, 01.2008, p. 78-85.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - S100A11, an dual mediator for growth regulation of human keratinocytes
AU - Sakaguchi, Masakiyo
AU - Sonegawa, Hiroyuki
AU - Murata, Hitoshi
AU - Kitazoe, Midori
AU - Futami, Junichiro
AU - Kataoka, Ken
AU - Yamada, Hidenori
AU - Huh, Nam Ho
PY - 2008/1
Y1 - 2008/1
N2 - We previously revealed a novel signal pathway involving S100A11 for inhibition of the growth of normal human keratinocytes (NHK) caused by high Ca++ or transforming growth factor β. Exposure to either agent resulted in transfer of S100A11 to nuclei, where it induced p21WAF1. In contrast, S100A11 has been shown to be overexpressed in many human cancers. To address this apparent discrepancy, we analyzed possible new functions of S100A11, and we provide herein evidence that 1) S100A11 is actively secreted by NHK; 2) extracellular S100A11 acts on NHK to enhance the production of epidermal growth factor family proteins, resulting in growth stimulation; 3) receptor for advanced glycation end products, nuclear factor-κB, Akt, and cAMP response element-binding protein are involved in the S100A11-triggered signal transduction; and 4) production and secretion of S100A11 are markedly enhanced in human squamous cancer cells. These findings indicate that S100A11 plays a dual role in growth regulation of epithelial cells.
AB - We previously revealed a novel signal pathway involving S100A11 for inhibition of the growth of normal human keratinocytes (NHK) caused by high Ca++ or transforming growth factor β. Exposure to either agent resulted in transfer of S100A11 to nuclei, where it induced p21WAF1. In contrast, S100A11 has been shown to be overexpressed in many human cancers. To address this apparent discrepancy, we analyzed possible new functions of S100A11, and we provide herein evidence that 1) S100A11 is actively secreted by NHK; 2) extracellular S100A11 acts on NHK to enhance the production of epidermal growth factor family proteins, resulting in growth stimulation; 3) receptor for advanced glycation end products, nuclear factor-κB, Akt, and cAMP response element-binding protein are involved in the S100A11-triggered signal transduction; and 4) production and secretion of S100A11 are markedly enhanced in human squamous cancer cells. These findings indicate that S100A11 plays a dual role in growth regulation of epithelial cells.
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U2 - 10.1091/mbc.E07-07-0682
DO - 10.1091/mbc.E07-07-0682
M3 - Article
VL - 19
SP - 78
EP - 85
JO - Molecular Biology of the Cell
JF - Molecular Biology of the Cell
SN - 1059-1524
IS - 1
ER -