S-[2-Carboxy-1-(1 H-imidazol-4-yl)ethyl]cysteine in normal human urine

M. Kinuta; N. Masuoka; K. Yao; J. Ohta; S. Yoshida; S. Futani; T. Ubuka

doi:10.1007/BF00806924

S-[2-Carboxy-1-(1 H-imidazol-4-yl)ethyl]cysteine in normal human urine

M. Kinuta, N. Masuoka, K. Yao, J. Ohta, S. Yoshida, S. Futani, T. Ubuka

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

A compound, which had the same mobility on a high-voltage paper electrophoretogram and the same R_F value on a thin-layer chromatogram as those of S-[2-carboxy-1-(1 H-imidazol-4-yl)ethyl]cysteine (I), was partially purified from human urine by ion-exchange column chromatography. The compound gave a signal at m/z 260 on its FAB mass spectrum, which was assigned as MH⁺ of compound I. These results suggest that the urinary compound is compound I and it is a physiological precursor of 3-[(carboxymethyl)thio]-3-(1 H-imidazol-4-yl)propanoic acid [Kinuta et al., (1991) Biochem J 275: 617-621].

Original language	English
Pages (from-to)	259-262
Number of pages	4
Journal	Amino Acids
Volume	1
Issue number	2
DOIs	https://doi.org/10.1007/BF00806924
Publication status	Published - Jun 1 1991

Keywords

Amino acids
Cysteine
Human urine
Imidazole compound
Paper electrophoresis

ASJC Scopus subject areas

Biochemistry
Clinical Biochemistry
Organic Chemistry

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10.1007/BF00806924

Cite this

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title = "S-[2-Carboxy-1-(1 H-imidazol-4-yl)ethyl]cysteine in normal human urine",

abstract = "A compound, which had the same mobility on a high-voltage paper electrophoretogram and the same RF value on a thin-layer chromatogram as those of S-[2-carboxy-1-(1 H-imidazol-4-yl)ethyl]cysteine (I), was partially purified from human urine by ion-exchange column chromatography. The compound gave a signal at m/z 260 on its FAB mass spectrum, which was assigned as MH+ of compound I. These results suggest that the urinary compound is compound I and it is a physiological precursor of 3-[(carboxymethyl)thio]-3-(1 H-imidazol-4-yl)propanoic acid [Kinuta et al., (1991) Biochem J 275: 617-621].",

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T1 - S-[2-Carboxy-1-(1 H-imidazol-4-yl)ethyl]cysteine in normal human urine

AU - Kinuta, M.

AU - Masuoka, N.

AU - Yao, K.

AU - Ohta, J.

AU - Yoshida, S.

AU - Futani, S.

AU - Ubuka, T.

PY - 1991/6/1

Y1 - 1991/6/1

N2 - A compound, which had the same mobility on a high-voltage paper electrophoretogram and the same RF value on a thin-layer chromatogram as those of S-[2-carboxy-1-(1 H-imidazol-4-yl)ethyl]cysteine (I), was partially purified from human urine by ion-exchange column chromatography. The compound gave a signal at m/z 260 on its FAB mass spectrum, which was assigned as MH+ of compound I. These results suggest that the urinary compound is compound I and it is a physiological precursor of 3-[(carboxymethyl)thio]-3-(1 H-imidazol-4-yl)propanoic acid [Kinuta et al., (1991) Biochem J 275: 617-621].

AB - A compound, which had the same mobility on a high-voltage paper electrophoretogram and the same RF value on a thin-layer chromatogram as those of S-[2-carboxy-1-(1 H-imidazol-4-yl)ethyl]cysteine (I), was partially purified from human urine by ion-exchange column chromatography. The compound gave a signal at m/z 260 on its FAB mass spectrum, which was assigned as MH+ of compound I. These results suggest that the urinary compound is compound I and it is a physiological precursor of 3-[(carboxymethyl)thio]-3-(1 H-imidazol-4-yl)propanoic acid [Kinuta et al., (1991) Biochem J 275: 617-621].

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KW - Cysteine

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KW - Imidazole compound

KW - Paper electrophoresis

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S-[2-Carboxy-1-(1 H-imidazol-4-yl)ethyl]cysteine in normal human urine

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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