S-100 beta positive human T lymphocytes: Their characteristics and behavior under normal and pathologic conditions

K. Takahashi, T. Yoshino, K. Hayashi, H. Sonobe, Y. Ohtsuki

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

The characteristics of human S-100 beta-positive T lymphocytes (S-100 beta+ T cells) and their fluctuation in peripheral blood under normal and various pathologic conditions were investigated. S-100 beta+ T cells were small lymphocytes with no particular subcellular structures and showed a proliferative response to mitogens. They were present mainly in peripheral blood under normal conditions but accumulated in T zones of lymph nodes with nonspecific T-zone hyperplasia, where numerous interdigitating reticulum cells existed. In healthy adults approximately 1% to 4% (mean 3.4%) of peripheral blood mononuclear cells were S-100 beta+ T cells. The proportion of S-100 beta+ T cells in peripheral blood tended to significantly decrease (<0.5%) in patients with neoplastic diseases; this tendency was apparently related to tumor progression.

Original languageEnglish
Pages (from-to)214-220
Number of pages7
JournalBlood
Volume70
Issue number1
DOIs
Publication statusPublished - 1987
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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