Ru(II)-Catalyzed C-H Aminocarbonylation of N -(Hetero)aryl-7-azaindoles with Isocyanates

Taejoo Jeong, Suk Hun Lee, Rina Chun, Sangil Han, Sang Hoon Han, Yeong Uk Jeon, Jihye Park, Takehiko Yoshimitsu, Neeraj Kumar Mishra, In Su Kim

Research output: Contribution to journal › Article

6 Citations (Scopus)

Abstract

The ruthenium(II)-catalyzed C-H aminocarbonylation of N-(hetero)aryl-7-azaindoles with isocyanates is described. The excellent site selectivity at the ortho-position within the N-(hetero)aryl ring was observed to provide ortho-amidated N-(hetero)aryl-7-azaindoles under the mild reaction conditions. The resulting 7-azaindole derivatives can be readily transformed into 7-azaindoles containing carboxylic acid and alkyl amine functional groups.

Original languageEnglish
Pages (from-to)4641-4649
Number of pages9
JournalJournal of Organic Chemistry
Volume83
Issue number8
DOIs
Publication statusPublished - Apr 20 2018

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Isocyanates
Ruthenium
Carboxylic Acids
Functional groups
Amines
Derivatives
7-azaindole dimer

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Jeong, T., Lee, S. H., Chun, R., Han, S., Han, S. H., Jeon, Y. U., ... Kim, I. S. (2018). Ru(II)-Catalyzed C-H Aminocarbonylation of N -(Hetero)aryl-7-azaindoles with Isocyanates. Journal of Organic Chemistry, 83(8), 4641-4649. https://doi.org/10.1021/acs.joc.8b00388

Ru(II)-Catalyzed C-H Aminocarbonylation of N -(Hetero)aryl-7-azaindoles with Isocyanates. / Jeong, Taejoo; Lee, Suk Hun; Chun, Rina; Han, Sangil; Han, Sang Hoon; Jeon, Yeong Uk; Park, Jihye; Yoshimitsu, Takehiko; Mishra, Neeraj Kumar; Kim, In Su.

In: Journal of Organic Chemistry, Vol. 83, No. 8, 20.04.2018, p. 4641-4649.

Research output: Contribution to journal › Article

Jeong, T, Lee, SH, Chun, R, Han, S, Han, SH, Jeon, YU, Park, J, Yoshimitsu, T, Mishra, NK & Kim, IS 2018, 'Ru(II)-Catalyzed C-H Aminocarbonylation of N -(Hetero)aryl-7-azaindoles with Isocyanates', Journal of Organic Chemistry, vol. 83, no. 8, pp. 4641-4649. https://doi.org/10.1021/acs.joc.8b00388
Jeong T, Lee SH, Chun R, Han S, Han SH, Jeon YU et al. Ru(II)-Catalyzed C-H Aminocarbonylation of N -(Hetero)aryl-7-azaindoles with Isocyanates. Journal of Organic Chemistry. 2018 Apr 20;83(8):4641-4649. https://doi.org/10.1021/acs.joc.8b00388
Jeong, Taejoo ; Lee, Suk Hun ; Chun, Rina ; Han, Sangil ; Han, Sang Hoon ; Jeon, Yeong Uk ; Park, Jihye ; Yoshimitsu, Takehiko ; Mishra, Neeraj Kumar ; Kim, In Su. / Ru(II)-Catalyzed C-H Aminocarbonylation of N -(Hetero)aryl-7-azaindoles with Isocyanates. In: Journal of Organic Chemistry. 2018 ; Vol. 83, No. 8. pp. 4641-4649.
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