Ru(II)-Catalyzed C-H Aminocarbonylation of N -(Hetero)aryl-7-azaindoles with Isocyanates

Taejoo Jeong, Suk Hun Lee, Rina Chun, Sangil Han, Sang Hoon Han, Yeong Uk Jeon, Jihye Park, Takehiko Yoshimitsu, Neeraj Kumar Mishra, In Su Kim

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8 Citations (Scopus)


The ruthenium(II)-catalyzed C-H aminocarbonylation of N-(hetero)aryl-7-azaindoles with isocyanates is described. The excellent site selectivity at the ortho-position within the N-(hetero)aryl ring was observed to provide ortho-amidated N-(hetero)aryl-7-azaindoles under the mild reaction conditions. The resulting 7-azaindole derivatives can be readily transformed into 7-azaindoles containing carboxylic acid and alkyl amine functional groups.

Original languageEnglish
Pages (from-to)4641-4649
Number of pages9
JournalJournal of Organic Chemistry
Issue number8
Publication statusPublished - Apr 20 2018

ASJC Scopus subject areas

  • Organic Chemistry

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  • Cite this

    Jeong, T., Lee, S. H., Chun, R., Han, S., Han, S. H., Jeon, Y. U., Park, J., Yoshimitsu, T., Mishra, N. K., & Kim, I. S. (2018). Ru(II)-Catalyzed C-H Aminocarbonylation of N -(Hetero)aryl-7-azaindoles with Isocyanates. Journal of Organic Chemistry, 83(8), 4641-4649.