TY - JOUR
T1 - Ru(II)-Catalyzed C-H Aminocarbonylation of N -(Hetero)aryl-7-azaindoles with Isocyanates
AU - Jeong, Taejoo
AU - Lee, Suk Hun
AU - Chun, Rina
AU - Han, Sangil
AU - Han, Sang Hoon
AU - Jeon, Yeong Uk
AU - Park, Jihye
AU - Yoshimitsu, Takehiko
AU - Mishra, Neeraj Kumar
AU - Kim, In Su
PY - 2018/4/20
Y1 - 2018/4/20
N2 - The ruthenium(II)-catalyzed C-H aminocarbonylation of N-(hetero)aryl-7-azaindoles with isocyanates is described. The excellent site selectivity at the ortho-position within the N-(hetero)aryl ring was observed to provide ortho-amidated N-(hetero)aryl-7-azaindoles under the mild reaction conditions. The resulting 7-azaindole derivatives can be readily transformed into 7-azaindoles containing carboxylic acid and alkyl amine functional groups.
AB - The ruthenium(II)-catalyzed C-H aminocarbonylation of N-(hetero)aryl-7-azaindoles with isocyanates is described. The excellent site selectivity at the ortho-position within the N-(hetero)aryl ring was observed to provide ortho-amidated N-(hetero)aryl-7-azaindoles under the mild reaction conditions. The resulting 7-azaindole derivatives can be readily transformed into 7-azaindoles containing carboxylic acid and alkyl amine functional groups.
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U2 - 10.1021/acs.joc.8b00388
DO - 10.1021/acs.joc.8b00388
M3 - Article
C2 - 29616808
AN - SCOPUS:85045750506
VL - 83
SP - 4641
EP - 4649
JO - Journal of Organic Chemistry
JF - Journal of Organic Chemistry
SN - 0022-3263
IS - 8
ER -