Abstract
The ruthenium(II)-catalyzed C-H aminocarbonylation of N-(hetero)aryl-7-azaindoles with isocyanates is described. The excellent site selectivity at the ortho-position within the N-(hetero)aryl ring was observed to provide ortho-amidated N-(hetero)aryl-7-azaindoles under the mild reaction conditions. The resulting 7-azaindole derivatives can be readily transformed into 7-azaindoles containing carboxylic acid and alkyl amine functional groups.
Original language | English |
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Pages (from-to) | 4641-4649 |
Number of pages | 9 |
Journal | Journal of Organic Chemistry |
Volume | 83 |
Issue number | 8 |
DOIs | |
Publication status | Published - Apr 20 2018 |
ASJC Scopus subject areas
- Organic Chemistry