Royal jelly ameliorates insulin resistance in fructose-drinking rats

Yoshito Zamami, Shingo Takatori, Mitsuhiro Goda, Toshihiro Koyama, Yukiko Iwatani, Xin Jin, Shima Takai-Doi, Hiromu Kawasaki

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56 Citations (Scopus)

Abstract

Royal jelly (RJ) is known to contain excellent nutrition and a variety of biological activities. The present study was designed to investigate the effects of RJ on insulin resistance (hyperinsulinemia) in fructose-drinking rats (FDR; insulin resistance animal model). Male Wistar rats (6 weeks old) received 15% fructose solution in drinking water for 8 weeks. FDR showed significant increases in plasma levels of insulin and triglyceride, Homeostasis Model Assessment ratio (HOMA-R, an index of insulin resistance), and systolic blood pressure, but not blood glucose levels, when compared with control rats. RJ (100, 300 mg/kg, p.o.) treatment for 8 weeks significantly decreased the plasma levels of insulin and triglyceride, HOMA-R, without affecting blood glucose or total cholesterol levels and tended to lower systolic blood pressure. In isolated and perfused mesenteric vascular beds of FDR, RJ treatment resulted in a significant reduction in sympathetic nerve-mediated vasoconstrictor response to periarterial nerve stimulation (PNS) and tended to increase the calcitonin gene-related peptide (CGRP) nerve-mediated vasodilator response to PNS, compared with those in untreated FDR. However, RJ treatment did not significantly affect norepinephrine-induced vasoconstriction or CGRP-induced vasodilation. These results suggest that RJ could be an effective functional food to prevent insulin resistance associated with the development of hypertension.

Original languageEnglish
Pages (from-to)2103-2107
Number of pages5
JournalBiological and Pharmaceutical Bulletin
Volume31
Issue number11
DOIs
Publication statusPublished - Nov 2008

Keywords

  • Fructose-drinking rat
  • Insulin resistance
  • Periarterial nerve function
  • Royal jelly

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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    Zamami, Y., Takatori, S., Goda, M., Koyama, T., Iwatani, Y., Jin, X., Takai-Doi, S., & Kawasaki, H. (2008). Royal jelly ameliorates insulin resistance in fructose-drinking rats. Biological and Pharmaceutical Bulletin, 31(11), 2103-2107. https://doi.org/10.1248/bpb.31.2103