Room-temperature palladium-catalyzed and copper(I)-mediated coupling reactions of acid chlorides with boronic acids under neutral conditions

Yasushi Nishihara, Yoshiaki Inoue, Mamoru Fujisawa, Kentaro Takagi

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

The palladium-catalyzed cross-coupling reactions of acid chlorides with arylboronic acids in the presence of copper(I) thiophene-2-carboxylate (CuTC) as an activator under strictly non-basic and mild reaction conditions afford the unsymmetrical ketones in moderate to excellent yields. A wide range of substrates bearing an electron-donating or an electron-withdrawing substituent on the aromatic ring is compatible.

Original languageEnglish
Pages (from-to)2309-2312
Number of pages4
JournalSynlett
Issue number15
DOIs
Publication statusPublished - Sep 19 2005

Keywords

  • Boronic acid
  • Copper
  • Cross-coupling reaction
  • Ketones
  • Palladium

ASJC Scopus subject areas

  • Organic Chemistry

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