Roles of oral bacteria in cardiovascular diseases - From molecular mechanisms to clinical cases: Implication of periodontal diseases in development of systemic diseases

Hiroaki Inaba, Atsuo Amano

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Periodontal diseases, some of the most common infectious diseases seen in humans, are characterized by gingival inflammation, as well as loss of connective tissue and bone from around the roots of the teeth, which leads to eventual tooth exfoliation. In the past decade, the association of periodontal diseases with the development of systemic diseases has received increasing attention. Although a number of studies have presented evidence of close relationships between periodontal and systemic diseases, the majority of findings are limited to epidemiological studies, while the etiological details remain unclear. Nevertheless, a variety of recent hypothesis driven investigations have compiled various results showing that periodontal infection and subsequent direct oral-hematogenous spread of bacteria are implicated in the development of various systemic diseases. Herein, we present current understanding in regard to the relationship between periodontal and systemic diseases, including cardiovascular diseases, preterm delivery of low birth weight, diabetes mellitus, respiratory diseases, and osteoporosis.

Original languageEnglish
Pages (from-to)103-109
Number of pages7
JournalJournal of Pharmacological Sciences
Volume113
Issue number2
DOIs
Publication statusPublished - Jun 15 2010
Externally publishedYes

Keywords

  • Cardiovascular disease
  • Diabetes mellitus
  • Oral bacteria
  • Periodontal disease
  • Porphyromonas gingivalis
  • Preterm delivery

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

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