TY - JOUR
T1 - Roles of intracellular Ca2+ and cyclic AMP in mast cell histamine release induced by radiographic contrast media
AU - Saito, Mami
AU - Itoh, Yoshinori
AU - Yano, Takahisa
AU - Sendo, Toshiaki
AU - Goromaru, Takeshi
AU - Sakai, Naoko
AU - Oishi, Ryozo
N1 - Funding Information:
cellular Ca2+ but temperature-dependent. Consistent with Cogen FC, Norman ME, Dunsky E, Hirshfeld J, Zweiman B (1979) their results, in the present study, the ioxaglate-induced Histamine release and complement changes following injection histamine release was not affected by the removal of ex-303of contrast media in humans. J Allergy Clin Immunol 64:299– tracellular Ca2+. However, it was noteworthy that the re-Eloy R, Corot C, Belleville J (1991) Contrast media for angiogra- moval of intracellular Ca2+ by chelation with BAPTA/AM phy: physicochemical properties, pharmacokinetics and bio-significantly reduced the ioxaglate-induced mast cell hist-compatibility. Clin Mater 7:89–97 amine release. These findings suggest that RCM stimulate cells by centrifugation on density gradients of Percoll. J Im-Enerback L, Svensson I (1980) Isolation of rat peritoneal mast the release of Ca2+ from intracellular Ca2+ stores, which munol Methods 39:135–145 leads to the mast cell degranulation. Ennis M (1982) Histamine release from human pulmonary mast In conclusion, a variety of RCM stimulated histamine cells. Agents Actions 12:60–63 release from rat pulmonary cells, in which the action of vivo studies of radiographic contrast media-induced histamineEnnis M, Lorenz W, Nehring E, Schneider C (1991) In vitro and in ionic RCM was more pronounced than that of non-ionic release in pigs. Agents Actions 33:26–29 materials. There was no significant correlation between Galli SJ, Gordon JR, Wershil BK (1993) Mast cell cytokines in al-the osmolarity of RCM solution and the histamine release. lergy and inflammation. Agents Actions (Suppl) 43:209–220 In addition, hyperosmotic mannitol solution did not in-Genovese A, Stellato C, Patella V, Lamparter-Schummert B, de crease histamine release. The histamine-releasing action complete secretagogues acting on human basophils and mastCrescenzo G, Adt M, Marone G (1996) Contrast media are in- of ioxaglate was more marked in pulmonary than in peri-cells isolated from heart and lung, but not skin tissue. Int J Clin toneal cells. The ioxaglate-induced histamine release was Lab Res 26:192–198 reduced by DBcAMP or the elevation of endogenous cAMP Goromaru T, Sendo T, Itoh Y, Sakai N, Teshima D, Oishi R content. Consistent with these findings, ioxaglate lowered and subsequent stimulation of histamine Hand H receptors in(2002) Evidence for an involvement of mast cell degranulation the accumulation of mast cell cAMP. On the other hand, radiographic contrast media-increased vascular permeability in1 2 the removal of intracellular but not extracellular Ca2+ at- rats. Naunyn-Schmiedebergs Arch Pharmacol 366:605–612 tenuated the ioxaglate-induced histamine release from Itoh Y, Oishi R, Adachi N, Saeki K (1992) A highly sensitive as- pulmonary cells. Therefore, it is suggested that the reduc-umn fluorescent derivatization. J Neurochem 58:884–889say for histamine using ion-pair HPLC coupled with postcol- tion in cellular cAMP content and Ca2+ release from intra-Lalli AF (1980) Contrast media reactions: data analysis and hy- cellular stores contribute largely to mast cell histamine re- pothesis. Radiology 134:1–12 lease induced by RCM. Laroche D, Aimone-Gastin I, Dubois F, Huet H, Gerard P, Vergnaud MC, Mouton-Faivre C, Gueant JL, Laxenaire MC, Bricard H (1998) Mechanisms of severe, immediate reactions to iodinated contrast material. Radiology 209:35–36 Peachell PT, Morcos SK (1998) Effect of radiographic contrast media on histamine release from human mast cells and ba- sophils. Br J Radiol 71:24–30 Pinet A, Corot C, Biot N, Eloy R (1988) Evaluation of histamine release following intravenous injection of ionic and nonionic contrast media. Invest Radiol 23 [Suppl 1]:174–177 Rodriguez RM, Gueant JL, Gastin IA, Angioi M, Abdelmoutaleb I, Saint-Laudy J, Gerard P, Namour F, Grentzinger A, Romano A, Juilliere Y, Danchin N (2001) Comparison of effects of ioxaglate versus iomeprol on histamine and tryptase release in patients with ischemic cardiomyopathy. Am J Cardiol 88:185– 188 Rossie SS, Miller RJ (1982) Regulation of mast cell histamine re-lease by neurotensin. Life Sci 31:509–516 Salem DN, Findlay SR, Isner JM, Konstam MA, Cohen PF (1986a) Comparison of histamine release effects of ionic and non-ionic radiographic contrast media. Am J Med 80:382–384 Salem DN, Konstam MA, Isner JM, Bonin JD (1986b) Compari-son of the electrocardiographic and hemodynamic responses to ionic and nonionic radiocontrast media during left ventriculog-raphy: a randomized double-blind study. Am Heart J 111: 533–536 Sendo T, Hirakawa M, Fujie K, Kataoka Y, Oishi R (1999) Con-trast medium-induced pulmonary edema is aggravated by sili-cone contamination in rats. Radiology 212:97–102 Sendo T, Kataoka Y, Takeda Y, Furuta W, Oishi R (2000) Nitric oxide protects against contrast media-increased pulmonary vas-cular permeability in rats. Invest Radiol 35:472–478 Shehadi WH (1975) Adverse reactions to intravascularly adminis-tered contrast media: a comprehensive study based on a prospec-tive survey. Am J Radiol 124:145–152 Shichijo M, Inagaki N, Kimata M, Serizawa I, Saito H, Nagai H (1999) Role of cyclic 3’,5’-adenosine monophosphate in the regulation of chemical mediator release and cytokine produc-tion from cultured human mast cells. J Allergy Clin Immunol 103:S421–S428 Acknowledgement This research was supported in part by Grant-in-Aid for Scientific Research (C:13672390) from the Ministry of Education, Science, Sports and Culture, Japan.
PY - 2003/4/1
Y1 - 2003/4/1
N2 - Mast cell histamine release is considered to be associated with the etiology of anaphylactoid reactions to iodinated radiographic contrast media (RCM). In the present study, the effects of various ionic and non-ionic RCM on histamine release from mast cells were compared, and the possible mechanisms of the histamine release were subsequently determined. Both ionic (ioxaglate and amidotrizoate) and non-ionic (iohexol, ioversol, iomeprol, iopamidol and iotrolan) RCM increased histamine release from the dissociated rat pulmonary cells, whereby ionic materials were more potent than non-ionic agents. There was no significant correlation between the extent of histamine release and the osmolarity of each RCM solution. In addition, hyperosmotic mannitol solution (1000 mOsm/kg) caused no marked histamine release. Thus, it is unlikely that the hyperosmolarity of RCM solutions contributes to the histamine release. RCM also stimulated, but to a lesser extent, the histamine release from rat peritoneal cells. The RCM-induced histamine release from both types of cells was inhibited by dibutyl cyclic AMP or combined treatment with forskolin and 3-isobutyl-1-methylxanthine. Corresponding to these results, RCM markedly reduced the cellular cyclic AMP content. On the other hand, the removal of intracellular but not the extracellular Ca2+ attenuated the RCM-induced mast cell histamine release. From these findings, it is suggested that the decrease in cellular cyclic AMP content and an increase in intracellular Ca2+ contribute at least in part to the RCM-induced mast cell histamine release.
AB - Mast cell histamine release is considered to be associated with the etiology of anaphylactoid reactions to iodinated radiographic contrast media (RCM). In the present study, the effects of various ionic and non-ionic RCM on histamine release from mast cells were compared, and the possible mechanisms of the histamine release were subsequently determined. Both ionic (ioxaglate and amidotrizoate) and non-ionic (iohexol, ioversol, iomeprol, iopamidol and iotrolan) RCM increased histamine release from the dissociated rat pulmonary cells, whereby ionic materials were more potent than non-ionic agents. There was no significant correlation between the extent of histamine release and the osmolarity of each RCM solution. In addition, hyperosmotic mannitol solution (1000 mOsm/kg) caused no marked histamine release. Thus, it is unlikely that the hyperosmolarity of RCM solutions contributes to the histamine release. RCM also stimulated, but to a lesser extent, the histamine release from rat peritoneal cells. The RCM-induced histamine release from both types of cells was inhibited by dibutyl cyclic AMP or combined treatment with forskolin and 3-isobutyl-1-methylxanthine. Corresponding to these results, RCM markedly reduced the cellular cyclic AMP content. On the other hand, the removal of intracellular but not the extracellular Ca2+ attenuated the RCM-induced mast cell histamine release. From these findings, it is suggested that the decrease in cellular cyclic AMP content and an increase in intracellular Ca2+ contribute at least in part to the RCM-induced mast cell histamine release.
KW - Histamine
KW - Intracellular calcium
KW - Osmolarity
KW - Peritoneal mast cells
KW - Pulmonary mast cells
KW - Radiographic contrast media
UR - http://www.scopus.com/inward/record.url?scp=0038070308&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0038070308&partnerID=8YFLogxK
U2 - 10.1007/s00210-003-0706-7
DO - 10.1007/s00210-003-0706-7
M3 - Article
C2 - 12690428
AN - SCOPUS:0038070308
VL - 367
SP - 364
EP - 371
JO - Naunyn-Schmiedeberg's Archives of Pharmacology
JF - Naunyn-Schmiedeberg's Archives of Pharmacology
SN - 0028-1298
IS - 4
ER -