Roles of Collagen and Periostin Expression by Cranial Neural Crest Cells during Soft Palate Development

Kyoko Oka, Masaki J. Honda, Eichi Tsuruga, Yuji Hatakeyama, Keitaro Isokawa, Yoshihiko Sawa

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

The tissue in the palatal region can be divided into the hard and the soft palates, each having a specialized function such as occlusion, speech, or swallowing. Therefore, an understanding of the mechanism of palatogenesis in relation to the function of each region is important. However, in comparison with the hard palate, there is still a lack of information about the mechanisms of soft palate development. In this study, the authors investigated the contribution of cranial neural crest (CNC) cells to development of both hard and soft palates. They also demonstrated a unique pattern of periostin expression during soft palate development, which was closely related to that of collagen type I (Col I) in palatine aponeurosis. Furthermore, organ culture analysis showed that exogenous transforming growth factor-β (TGF-β) induced the expression of both periostin and Col I. These novel patterns of expression in the extracellular matrix (ECM) induced by CNC cells suggest that these cells may help to determine the character of both the hard and soft palates through ECM induction. TGF-β signaling appears to be one of the mediators of Col I and periostin expression in the formation of functional structures during soft palate development.

Original languageEnglish
Pages (from-to)57-68
Number of pages12
JournalJournal of Histochemistry and Cytochemistry
Volume60
Issue number1
DOIs
Publication statusPublished - Jan 2012
Externally publishedYes

Keywords

  • TGF-β
  • embryonic development
  • extracellular matrix
  • periostin
  • soft palate

ASJC Scopus subject areas

  • Anatomy
  • Histology

Fingerprint Dive into the research topics of 'Roles of Collagen and Periostin Expression by Cranial Neural Crest Cells during Soft Palate Development'. Together they form a unique fingerprint.

Cite this