Abstract
Vibrio mimicus (V. mimicus) is a causative agent of human gastroenteritis and food poisoning. Although several toxic or virulence factors have been isolated from the bacterium, an enterotoxic hemolysin is a sole toxin produced by all clinical isolates. In the present study, we found that the antibody against the hemolysin significantly inhibited the fluid-accumulating action of the living cells inoculated into a rabbit ileal loop, and that the hemolysin gene (vmhA) was probably expressed by the bacterium in the ileal loop. Additionally, in spit of the comparable motility and similar proteome profiles, a vmhA mutant revealed the reduced fluid-accumulating activity. Theses findings suggest that the hemolysin contributes to full virulence of V. mimicus.
Original language | English |
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Pages (from-to) | 686-691 |
Number of pages | 6 |
Journal | Journal of Health Science |
Volume | 54 |
Issue number | 6 |
DOIs | |
Publication status | Published - Dec 2008 |
Keywords
- Hemolysin
- Vibrio mimicus
- Virulence factor
ASJC Scopus subject areas
- Toxicology
- Health, Toxicology and Mutagenesis