Role of the enterotoxic hemolysin in pathogenicity of Vibrio mimicus

Tao Li, Akiko Kobayashi, Noriko Takata, Tomonaga Yoshimura, Yoko Maehara, Tomofusa Tsuchiya, Shin Ichi Miyoshi

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Vibrio mimicus (V. mimicus) is a causative agent of human gastroenteritis and food poisoning. Although several toxic or virulence factors have been isolated from the bacterium, an enterotoxic hemolysin is a sole toxin produced by all clinical isolates. In the present study, we found that the antibody against the hemolysin significantly inhibited the fluid-accumulating action of the living cells inoculated into a rabbit ileal loop, and that the hemolysin gene (vmhA) was probably expressed by the bacterium in the ileal loop. Additionally, in spit of the comparable motility and similar proteome profiles, a vmhA mutant revealed the reduced fluid-accumulating activity. Theses findings suggest that the hemolysin contributes to full virulence of V. mimicus.

Original languageEnglish
Pages (from-to)686-691
Number of pages6
JournalJournal of Health Science
Volume54
Issue number6
DOIs
Publication statusPublished - Dec 2008

Keywords

  • Hemolysin
  • Vibrio mimicus
  • Virulence factor

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

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    Li, T., Kobayashi, A., Takata, N., Yoshimura, T., Maehara, Y., Tsuchiya, T., & Miyoshi, S. I. (2008). Role of the enterotoxic hemolysin in pathogenicity of Vibrio mimicus. Journal of Health Science, 54(6), 686-691. https://doi.org/10.1248/jhs.54.686