Abstract
Vibrio mimicus (V. mimicus) is a causative agent of human gastroenteritis and food poisoning. Although several toxic or virulence factors have been isolated from the bacterium, an enterotoxic hemolysin is a sole toxin produced by all clinical isolates. In the present study, we found that the antibody against the hemolysin significantly inhibited the fluid-accumulating action of the living cells inoculated into a rabbit ileal loop, and that the hemolysin gene (vmhA) was probably expressed by the bacterium in the ileal loop. Additionally, in spit of the comparable motility and similar proteome profiles, a vmhA mutant revealed the reduced fluid-accumulating activity. Theses findings suggest that the hemolysin contributes to full virulence of V. mimicus.
| Original language | English |
|---|---|
| Pages (from-to) | 686-691 |
| Number of pages | 6 |
| Journal | Journal of Health Science |
| Volume | 54 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Dec 2008 |
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Keywords
- Hemolysin
- Vibrio mimicus
- Virulence factor
ASJC Scopus subject areas
- Toxicology
- Health, Toxicology and Mutagenesis
Cite this
Role of the enterotoxic hemolysin in pathogenicity of Vibrio mimicus. / Li, Tao; Kobayashi, Akiko; Takata, Noriko; Yoshimura, Tomonaga; Maehara, Yoko; Tsuchiya, Tomofusa; Miyoshi, Shin-ichi.
In: Journal of Health Science, Vol. 54, No. 6, 12.2008, p. 686-691.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Role of the enterotoxic hemolysin in pathogenicity of Vibrio mimicus
AU - Li, Tao
AU - Kobayashi, Akiko
AU - Takata, Noriko
AU - Yoshimura, Tomonaga
AU - Maehara, Yoko
AU - Tsuchiya, Tomofusa
AU - Miyoshi, Shin-ichi
PY - 2008/12
Y1 - 2008/12
N2 - Vibrio mimicus (V. mimicus) is a causative agent of human gastroenteritis and food poisoning. Although several toxic or virulence factors have been isolated from the bacterium, an enterotoxic hemolysin is a sole toxin produced by all clinical isolates. In the present study, we found that the antibody against the hemolysin significantly inhibited the fluid-accumulating action of the living cells inoculated into a rabbit ileal loop, and that the hemolysin gene (vmhA) was probably expressed by the bacterium in the ileal loop. Additionally, in spit of the comparable motility and similar proteome profiles, a vmhA mutant revealed the reduced fluid-accumulating activity. Theses findings suggest that the hemolysin contributes to full virulence of V. mimicus.
AB - Vibrio mimicus (V. mimicus) is a causative agent of human gastroenteritis and food poisoning. Although several toxic or virulence factors have been isolated from the bacterium, an enterotoxic hemolysin is a sole toxin produced by all clinical isolates. In the present study, we found that the antibody against the hemolysin significantly inhibited the fluid-accumulating action of the living cells inoculated into a rabbit ileal loop, and that the hemolysin gene (vmhA) was probably expressed by the bacterium in the ileal loop. Additionally, in spit of the comparable motility and similar proteome profiles, a vmhA mutant revealed the reduced fluid-accumulating activity. Theses findings suggest that the hemolysin contributes to full virulence of V. mimicus.
KW - Hemolysin
KW - Vibrio mimicus
KW - Virulence factor
UR - http://www.scopus.com/inward/record.url?scp=57349182545&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=57349182545&partnerID=8YFLogxK
U2 - 10.1248/jhs.54.686
DO - 10.1248/jhs.54.686
M3 - Article
AN - SCOPUS:57349182545
VL - 54
SP - 686
EP - 691
JO - Journal of Health Science
JF - Journal of Health Science
SN - 1344-9702
IS - 6
ER -